FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291019979> ?p ?o ?g. }

• W4291019979 abstract "Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder that exhibits neurobehavioral deficits characterized by abnormalities in social interactions, deficits in communication as well as restricted interests, and repetitive behaviors. The basal ganglia is one of the brain regions implicated as dysfunctional in ASD. In particular, the defects in corticostriatal function have been reported to be involved in the pathogenesis of ASD. Surface deformation of the striatum in the brains of patients with ASD and their correlation with behavioral symptoms was reported in magnetic resonance imaging (MRI) studies. We demonstrated that prenatal valproic acid (VPA) exposure induced synaptic and molecular changes and decreased neuronal activity in the striatum. Using RNA sequencing (RNA-Seq), we analyzed transcriptome alterations in striatal tissues from 10-week-old prenatally VPA-exposed BALB/c male mice. Among the upregulated genes, Nurr1 was significantly upregulated in striatal tissues from prenatally VPA-exposed mice. Viral knockdown of Nurr1 by shRNA significantly rescued the reduction in dendritic spine density and the number of mature dendritic spines in the striatum and markedly improved social deficits in prenatally VPA-exposed mice. In addition, treatment with amodiaquine, which is a known ligand for Nurr1, mimicked the social deficits and synaptic abnormalities in saline-exposed mice as observed in prenatally VPA-exposed mice. Furthermore, PatDp+/− mice, a commonly used ASD genetic mouse model, also showed increased levels of Nurr1 in the striatum. Taken together, these results suggest that the increase in Nurr1 expression in the striatum is a mechanism related to the changes in synaptic deficits and behavioral phenotypes of the VPA-induced ASD mouse model." @default.
• W4291019979 created "2022-08-13" @default.
• W4291019979 creator A5020583845 @default.
• W4291019979 creator A5023663255 @default.
• W4291019979 creator A5050710756 @default.
• W4291019979 creator A5058214144 @default.
• W4291019979 creator A5064828338 @default.
• W4291019979 creator A5068936847 @default.
• W4291019979 creator A5073695220 @default.
• W4291019979 creator A5074027170 @default.
• W4291019979 creator A5091402286 @default.
• W4291019979 date "2022-08-09" @default.
• W4291019979 modified "2023-10-16" @default.
• W4291019979 title "Transcriptomic analysis in the striatum reveals the involvement of Nurr1 in the social behavior of prenatally valproic acid-exposed male mice" @default.
• W4291019979 cites W1814421085 @default.
• W4291019979 cites W1972817961 @default.
• W4291019979 cites W1974157217 @default.
• W4291019979 cites W1982292433 @default.
• W4291019979 cites W1983688248 @default.
• W4291019979 cites W1993621007 @default.
• W4291019979 cites W1995200202 @default.
• W4291019979 cites W2011209444 @default.
• W4291019979 cites W2012002548 @default.
• W4291019979 cites W2032319596 @default.
• W4291019979 cites W2035054293 @default.
• W4291019979 cites W2035716975 @default.
• W4291019979 cites W2048841722 @default.
• W4291019979 cites W2050620042 @default.
• W4291019979 cites W2051044828 @default.
• W4291019979 cites W2057250808 @default.
• W4291019979 cites W2059362512 @default.
• W4291019979 cites W2076040334 @default.
• W4291019979 cites W2076683771 @default.
• W4291019979 cites W2085553753 @default.
• W4291019979 cites W2109002457 @default.
• W4291019979 cites W2114803320 @default.
• W4291019979 cites W2116794070 @default.
• W4291019979 cites W2117487291 @default.
• W4291019979 cites W2128290890 @default.
• W4291019979 cites W2142502754 @default.
• W4291019979 cites W2146855895 @default.
• W4291019979 cites W2147765011 @default.
• W4291019979 cites W2148147266 @default.
• W4291019979 cites W2152161119 @default.
• W4291019979 cites W2152754204 @default.
• W4291019979 cites W2196375380 @default.
• W4291019979 cites W2253338868 @default.
• W4291019979 cites W2310417648 @default.
• W4291019979 cites W2343875542 @default.
• W4291019979 cites W2344738037 @default.
• W4291019979 cites W2419599148 @default.
• W4291019979 cites W2474912336 @default.
• W4291019979 cites W2510384759 @default.
• W4291019979 cites W2516804127 @default.
• W4291019979 cites W2524694180 @default.
• W4291019979 cites W2536727554 @default.
• W4291019979 cites W2549746016 @default.
• W4291019979 cites W2555001585 @default.
• W4291019979 cites W2605411260 @default.
• W4291019979 cites W2673247938 @default.
• W4291019979 cites W2732018791 @default.
• W4291019979 cites W2733731848 @default.
• W4291019979 cites W2796024220 @default.
• W4291019979 cites W2796252724 @default.
• W4291019979 cites W2803103118 @default.
• W4291019979 cites W2806874835 @default.
• W4291019979 cites W2808426286 @default.
• W4291019979 cites W2902000867 @default.
• W4291019979 cites W2902934807 @default.
• W4291019979 cites W2908066074 @default.
• W4291019979 cites W2933564878 @default.
• W4291019979 cites W2945401030 @default.
• W4291019979 cites W2951597665 @default.
• W4291019979 cites W2969366465 @default.
• W4291019979 cites W3027679849 @default.
• W4291019979 cites W3098098422 @default.
• W4291019979 doi "https://doi.org/10.1038/s41398-022-02056-z" @default.
• W4291019979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35945212" @default.
• W4291019979 hasPublicationYear "2022" @default.
• W4291019979 type Work @default.
• W4291019979 citedByCount "1" @default.
• W4291019979 countsByYear W42910199792023 @default.
• W4291019979 crossrefType "journal-article" @default.
• W4291019979 hasAuthorship W4291019979A5020583845 @default.
• W4291019979 hasAuthorship W4291019979A5023663255 @default.
• W4291019979 hasAuthorship W4291019979A5050710756 @default.
• W4291019979 hasAuthorship W4291019979A5058214144 @default.
• W4291019979 hasAuthorship W4291019979A5064828338 @default.
• W4291019979 hasAuthorship W4291019979A5068936847 @default.
• W4291019979 hasAuthorship W4291019979A5073695220 @default.
• W4291019979 hasAuthorship W4291019979A5074027170 @default.
• W4291019979 hasAuthorship W4291019979A5091402286 @default.
• W4291019979 hasBestOaLocation W42910199791 @default.
• W4291019979 hasConcept C104317684 @default.
• W4291019979 hasConcept C126322002 @default.
• W4291019979 hasConcept C127561419 @default.
• W4291019979 hasConcept C134018914 @default.
• W4291019979 hasConcept C148762608 @default.
• W4291019979 hasConcept C150194340 @default.
• W4291019979 hasConcept C15744967 @default.

• next