FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291036705> ?p ?o ?g. }

• W4291036705 endingPage "104925" @default.
• W4291036705 startingPage "104925" @default.
• W4291036705 abstract "Pharmacologically active compounds with known biological targets were evaluated for inhibition of SARS-CoV-2 infection in cell and tissue models to help identify potent classes of active small molecules and to better understand host-virus interactions. We evaluated 6,710 clinical and preclinical compounds targeting 2,183 host proteins by immunocytofluorescence-based screening to identify SARS-CoV-2 infection inhibitors. Computationally integrating relationships between small molecule structure, dose-response antiviral activity, host target, and cell interactome produced cellular networks important for infection. This analysis revealed 389 small molecules with micromolar to low nanomolar activities, representing >12 scaffold classes and 813 host targets. Representatives were evaluated for mechanism of action in stable and primary human cell models with SARS-CoV-2 variants and MERS-CoV. One promising candidate, obatoclax, significantly reduced SARS-CoV-2 viral lung load in mice. Ultimately, this work establishes a rigorous approach for future pharmacological and computational identification of host factor dependencies and treatments for viral diseases." @default.
• W4291036705 created "2022-08-13" @default.
• W4291036705 creator A5005414836 @default.
• W4291036705 creator A5014551736 @default.
• W4291036705 creator A5024819794 @default.
• W4291036705 creator A5024890858 @default.
• W4291036705 creator A5025914907 @default.
• W4291036705 creator A5028396638 @default.
• W4291036705 creator A5031518827 @default.
• W4291036705 creator A5035329188 @default.
• W4291036705 creator A5038976962 @default.
• W4291036705 creator A5042358991 @default.
• W4291036705 creator A5044341935 @default.
• W4291036705 creator A5045915497 @default.
• W4291036705 creator A5046790968 @default.
• W4291036705 creator A5047725378 @default.
• W4291036705 creator A5049183478 @default.
• W4291036705 creator A5053063202 @default.
• W4291036705 creator A5055113366 @default.
• W4291036705 creator A5056219406 @default.
• W4291036705 creator A5064702593 @default.
• W4291036705 creator A5065902435 @default.
• W4291036705 creator A5076850332 @default.
• W4291036705 creator A5077494562 @default.
• W4291036705 creator A5081019564 @default.
• W4291036705 creator A5082282921 @default.
• W4291036705 creator A5084280102 @default.
• W4291036705 creator A5086052373 @default.
• W4291036705 date "2022-09-01" @default.
• W4291036705 modified "2023-10-18" @default.
• W4291036705 title "Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization" @default.
• W4291036705 cites W1629166361 @default.
• W4291036705 cites W1971597874 @default.
• W4291036705 cites W1976741900 @default.
• W4291036705 cites W1988037271 @default.
• W4291036705 cites W1991001144 @default.
• W4291036705 cites W2006665219 @default.
• W4291036705 cites W2049544802 @default.
• W4291036705 cites W2056782561 @default.
• W4291036705 cites W2070050178 @default.
• W4291036705 cites W2070765025 @default.
• W4291036705 cites W2113068679 @default.
• W4291036705 cites W2138324310 @default.
• W4291036705 cites W2166209197 @default.
• W4291036705 cites W2172557341 @default.
• W4291036705 cites W2174898867 @default.
• W4291036705 cites W2212640525 @default.
• W4291036705 cites W2263739890 @default.
• W4291036705 cites W2399662436 @default.
• W4291036705 cites W2405035126 @default.
• W4291036705 cites W2513030033 @default.
• W4291036705 cites W2564700760 @default.
• W4291036705 cites W2604527271 @default.
• W4291036705 cites W2606332821 @default.
• W4291036705 cites W2783354632 @default.
• W4291036705 cites W2811106513 @default.
• W4291036705 cites W2888047332 @default.
• W4291036705 cites W2896231494 @default.
• W4291036705 cites W2898701738 @default.
• W4291036705 cites W2972807030 @default.
• W4291036705 cites W2984592516 @default.
• W4291036705 cites W2999403252 @default.
• W4291036705 cites W3003217347 @default.
• W4291036705 cites W3008443627 @default.
• W4291036705 cites W3009723094 @default.
• W4291036705 cites W3009912996 @default.
• W4291036705 cites W3012652877 @default.
• W4291036705 cites W3020909574 @default.
• W4291036705 cites W3026773347 @default.
• W4291036705 cites W3033015248 @default.
• W4291036705 cites W3034024339 @default.
• W4291036705 cites W3036391214 @default.
• W4291036705 cites W3041968020 @default.
• W4291036705 cites W3044927477 @default.
• W4291036705 cites W3047775844 @default.
• W4291036705 cites W3080378920 @default.
• W4291036705 cites W3085591857 @default.
• W4291036705 cites W3094597057 @default.
• W4291036705 cites W3095153958 @default.
• W4291036705 cites W3107607221 @default.
• W4291036705 cites W3131139331 @default.
• W4291036705 cites W3131511696 @default.
• W4291036705 cites W3134425030 @default.
• W4291036705 cites W3137359073 @default.
• W4291036705 cites W3158868742 @default.
• W4291036705 cites W3173547614 @default.
• W4291036705 cites W4205392594 @default.
• W4291036705 cites W4206067585 @default.
• W4291036705 cites W4247115498 @default.
• W4291036705 cites W4283258331 @default.
• W4291036705 doi "https://doi.org/10.1016/j.isci.2022.104925" @default.
• W4291036705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35992305" @default.
• W4291036705 hasPublicationYear "2022" @default.
• W4291036705 type Work @default.
• W4291036705 citedByCount "8" @default.
• W4291036705 countsByYear W42910367052022 @default.
• W4291036705 countsByYear W42910367052023 @default.
• W4291036705 crossrefType "journal-article" @default.

• next