Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291036706> ?p ?o ?g. }
- W4291036706 endingPage "104926" @default.
- W4291036706 startingPage "104926" @default.
- W4291036706 abstract "Secondary infections contribute significantly to covid-19 mortality but driving factors remain poorly understood. Autopsies of 20 covid-19 cases and 14 controls from the first pandemic wave complemented with microbial cultivation and RNA-seq from lung tissues enabled description of major organ pathologies and specification of secondary infections. Lethal covid-19 segregated into two main death causes with either dominant diffuse alveolar damage (DAD) or secondary pneumonias. The lung microbiome in covid-19 showed a reduced biodiversity and increased prototypical bacterial and fungal pathogens in cases of secondary pneumonias. RNA-seq distinctly mirrored death causes and stratified DAD cases into subgroups with differing cellular compositions identifying myeloid cells, macrophages and complement C1q as strong separating factors suggesting a pathophysiological link. Together with a prominent induction of inhibitory immune-checkpoints our study highlights profound alterations of the lung immunity in covid-19 wherein a reduced antimicrobial defense likely drives development of secondary infections on top of SARS-CoV-2 infection." @default.
- W4291036706 created "2022-08-13" @default.
- W4291036706 creator A5016018148 @default.
- W4291036706 creator A5017256744 @default.
- W4291036706 creator A5029200390 @default.
- W4291036706 creator A5029505414 @default.
- W4291036706 creator A5032058761 @default.
- W4291036706 creator A5034338334 @default.
- W4291036706 creator A5037132971 @default.
- W4291036706 creator A5039095165 @default.
- W4291036706 creator A5042291706 @default.
- W4291036706 creator A5045437890 @default.
- W4291036706 creator A5046072249 @default.
- W4291036706 creator A5047320465 @default.
- W4291036706 creator A5047726716 @default.
- W4291036706 creator A5050209868 @default.
- W4291036706 creator A5050659308 @default.
- W4291036706 creator A5062226170 @default.
- W4291036706 creator A5063002725 @default.
- W4291036706 creator A5065697845 @default.
- W4291036706 creator A5068132665 @default.
- W4291036706 creator A5069517102 @default.
- W4291036706 creator A5076777498 @default.
- W4291036706 creator A5079837194 @default.
- W4291036706 creator A5081837869 @default.
- W4291036706 creator A5083528269 @default.
- W4291036706 creator A5084198060 @default.
- W4291036706 date "2022-09-01" @default.
- W4291036706 modified "2023-09-30" @default.
- W4291036706 title "Host and microbiome features of secondary infections in lethal covid-19" @default.
- W4291036706 cites W1792671145 @default.
- W4291036706 cites W1981900811 @default.
- W4291036706 cites W1988460088 @default.
- W4291036706 cites W1996743514 @default.
- W4291036706 cites W2005580535 @default.
- W4291036706 cites W2013974818 @default.
- W4291036706 cites W2029933663 @default.
- W4291036706 cites W2034285706 @default.
- W4291036706 cites W2034351496 @default.
- W4291036706 cites W2104966044 @default.
- W4291036706 cites W2114054457 @default.
- W4291036706 cites W2114104545 @default.
- W4291036706 cites W2114232619 @default.
- W4291036706 cites W2130410032 @default.
- W4291036706 cites W2131026689 @default.
- W4291036706 cites W2133856765 @default.
- W4291036706 cites W2134526812 @default.
- W4291036706 cites W2137015675 @default.
- W4291036706 cites W2139607253 @default.
- W4291036706 cites W2155893315 @default.
- W4291036706 cites W2162509998 @default.
- W4291036706 cites W2167944937 @default.
- W4291036706 cites W2169456326 @default.
- W4291036706 cites W2170551349 @default.
- W4291036706 cites W2211662711 @default.
- W4291036706 cites W2401404581 @default.
- W4291036706 cites W2402456610 @default.
- W4291036706 cites W2496661162 @default.
- W4291036706 cites W2522270818 @default.
- W4291036706 cites W2561758149 @default.
- W4291036706 cites W2572519177 @default.
- W4291036706 cites W2587584091 @default.
- W4291036706 cites W2598461075 @default.
- W4291036706 cites W2622909676 @default.
- W4291036706 cites W2782746707 @default.
- W4291036706 cites W2802595885 @default.
- W4291036706 cites W2804172422 @default.
- W4291036706 cites W2900030356 @default.
- W4291036706 cites W2915839491 @default.
- W4291036706 cites W2921513648 @default.
- W4291036706 cites W2944490563 @default.
- W4291036706 cites W2951878836 @default.
- W4291036706 cites W2952001873 @default.
- W4291036706 cites W2952045272 @default.
- W4291036706 cites W2963276645 @default.
- W4291036706 cites W2995149669 @default.
- W4291036706 cites W3001195213 @default.
- W4291036706 cites W3014663601 @default.
- W4291036706 cites W3016123694 @default.
- W4291036706 cites W3016489853 @default.
- W4291036706 cites W3023982717 @default.
- W4291036706 cites W3023991776 @default.
- W4291036706 cites W3024643080 @default.
- W4291036706 cites W3025098045 @default.
- W4291036706 cites W3027918021 @default.
- W4291036706 cites W3030748957 @default.
- W4291036706 cites W3031410640 @default.
- W4291036706 cites W3033283737 @default.
- W4291036706 cites W3036042332 @default.
- W4291036706 cites W3036101703 @default.
- W4291036706 cites W3041595964 @default.
- W4291036706 cites W3041960835 @default.
- W4291036706 cites W3045715678 @default.
- W4291036706 cites W3047564875 @default.
- W4291036706 cites W3048443418 @default.
- W4291036706 cites W3082365904 @default.
- W4291036706 cites W3082704225 @default.
- W4291036706 cites W3085326737 @default.