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- W4291036707 abstract "Memory T cells underpin vaccine-induced immunity but are not yet fully understood. To distinguish features of memory cells that confer protective immunity, we used single cell transcriptome analysis to compare antigen-specific CD4+T cells recalled to lungs of mice that received a protective or nonprotective subunit vaccine followed by challenge with a fungal pathogen. We unexpectedly found populations specific to protection that expressed a strong type I interferon response signature, whose distinctive transcriptional signature appeared unconventionally dependent on IFN-γ receptor. We also detected a unique population enriched in protection that highly expressed the gene for the natural killer cell marker NKG7. Lastly, we detected differences in TCR gene use and in Th1- and Th17-skewed responses after protective and nonprotective vaccine, respectively, reflecting heterogeneous Ifng- and Il17a-expressing populations. Our findings highlight key features of transcriptionally diverse and distinctive antigen-specific T cells associated with protective vaccine-induced immunity." @default.
- W4291036707 created "2022-08-13" @default.
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- W4291036707 date "2022-09-01" @default.
- W4291036707 modified "2023-09-25" @default.
- W4291036707 title "Distinctive populations of CD4+T cells associated with vaccine efficacy" @default.
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- W4291036707 doi "https://doi.org/10.1016/j.isci.2022.104934" @default.
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