FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291123360> ?p ?o ?g. }

• W4291123360 endingPage "157" @default.
• W4291123360 startingPage "147" @default.
• W4291123360 abstract "Hypoxia/reoxygenation (H/R) induces pyroptosis in the setting of acute myocardial infarction (AMI). Previous studies have shown that the expression of the miR-15 family is stimulated in myocardial ischemia-reperfusion injury or H/R-induced cardiomyocyte injury, and miR-15 is a promoter of cardiac ischemia-reperfusion or H/R injury. However, whether miR-15b-5p regulates H/R injury and cardiomyocyte pyroptosis and its mechanism still need to be further clarified. Bioinformatics analysis elicited that SIRT3 was the downstream regulatory target gene of miR-15b-5p. SIRT3 has been shown to participate in the regulation of pyroptosis by negatively regulating the NLRP3 inflammasome pathway. Therefore, we hypothesized that miR-15b-5p targets SIRT3 and activated the NLRP3 inflammasome pathway to promote H/R-induced cardiomyocyte pyroptosis. We first show that H/R increases miR-15b-5p in rat cardiomyocytes H9C2. Next, we tested the effects of inhibition of miR-15b-5p or overexpression of SIRT3. We found that miR-15b-5p downregulation or SIRT3 overexpression could reverse the H/R-induced pyroptosis. Furthermore, silencing SIRT3 antagonized the protective effect of miR-15b-5p downregulation on H9C2 cells. NLRP3 inhibitor MCC950 annulled the previously mentioned antagonistic effect of silencing SIRT3 on the protection of miR-15b-5p downregulation against pyroptosis. We then used a rat AMI model to analyze myocardial infarction area by triphenyl tetrazolium chloride staining and assess serum cardiac troponin T level by ELISA and found that miR-15b-5p silencing reduced AMI injury in rats. Collectively, these results suggest that miR-15b-5p increase H/R-induced pyroptosis in cardiomyocytes by targeting SIRT3 and activating the NLRP3 inflammasome." @default.
• W4291123360 created "2022-08-13" @default.
• W4291123360 creator A5005283872 @default.
• W4291123360 creator A5082460712 @default.
• W4291123360 creator A5088207530 @default.
• W4291123360 date "2022-07-24" @default.
• W4291123360 modified "2023-09-27" @default.
• W4291123360 title "miR-15b-5p REGULATES THE NLRP3 INFLAMMASOME SIGNAL THROUGH TARGETING SIRT3 TO REGULATE HYPOXIA/REOXYGENATION-INDUCED CARDIOMYOCYTE PYROPTOSIS PROCESS" @default.
• W4291123360 cites W128258382 @default.
• W4291123360 cites W1643757759 @default.
• W4291123360 cites W2039374791 @default.
• W4291123360 cites W2084259236 @default.
• W4291123360 cites W2147526306 @default.
• W4291123360 cites W2147817343 @default.
• W4291123360 cites W2404138918 @default.
• W4291123360 cites W2520555298 @default.
• W4291123360 cites W2622564528 @default.
• W4291123360 cites W2786315758 @default.
• W4291123360 cites W2912896196 @default.
• W4291123360 cites W2952591371 @default.
• W4291123360 cites W2953512464 @default.
• W4291123360 cites W2971535807 @default.
• W4291123360 cites W3007268848 @default.
• W4291123360 cites W3011542636 @default.
• W4291123360 cites W3015849054 @default.
• W4291123360 cites W3042271435 @default.
• W4291123360 cites W3045843565 @default.
• W4291123360 cites W3104914338 @default.
• W4291123360 cites W3109328434 @default.
• W4291123360 cites W3112418112 @default.
• W4291123360 cites W3119732227 @default.
• W4291123360 cites W3120336706 @default.
• W4291123360 cites W3136651265 @default.
• W4291123360 cites W3137741184 @default.
• W4291123360 cites W3140524857 @default.
• W4291123360 cites W3160448436 @default.
• W4291123360 cites W3169747419 @default.
• W4291123360 cites W3170082459 @default.
• W4291123360 cites W3186053696 @default.
• W4291123360 cites W3189314649 @default.
• W4291123360 cites W3194779500 @default.
• W4291123360 cites W3195172850 @default.
• W4291123360 cites W3198281749 @default.
• W4291123360 cites W3198688804 @default.
• W4291123360 cites W3202844517 @default.
• W4291123360 cites W4252019796 @default.
• W4291123360 cites W3168360017 @default.
• W4291123360 doi "https://doi.org/10.1097/shk.0000000000001961" @default.
• W4291123360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35953459" @default.
• W4291123360 hasPublicationYear "2022" @default.
• W4291123360 type Work @default.
• W4291123360 citedByCount "4" @default.
• W4291123360 countsByYear W42911233602022 @default.
• W4291123360 countsByYear W42911233602023 @default.
• W4291123360 crossrefType "journal-article" @default.
• W4291123360 hasAuthorship W4291123360A5005283872 @default.
• W4291123360 hasAuthorship W4291123360A5082460712 @default.
• W4291123360 hasAuthorship W4291123360A5088207530 @default.
• W4291123360 hasConcept C104317684 @default.
• W4291123360 hasConcept C119056186 @default.
• W4291123360 hasConcept C119157956 @default.
• W4291123360 hasConcept C126322002 @default.
• W4291123360 hasConcept C127561419 @default.
• W4291123360 hasConcept C138488276 @default.
• W4291123360 hasConcept C17172800 @default.
• W4291123360 hasConcept C178790620 @default.
• W4291123360 hasConcept C185592680 @default.
• W4291123360 hasConcept C203014093 @default.
• W4291123360 hasConcept C2776914184 @default.
• W4291123360 hasConcept C2777209026 @default.
• W4291123360 hasConcept C2780561631 @default.
• W4291123360 hasConcept C502942594 @default.
• W4291123360 hasConcept C540031477 @default.
• W4291123360 hasConcept C541997718 @default.
• W4291123360 hasConcept C55493867 @default.
• W4291123360 hasConcept C71924100 @default.
• W4291123360 hasConcept C7836513 @default.
• W4291123360 hasConcept C86803240 @default.
• W4291123360 hasConcept C95444343 @default.
• W4291123360 hasConcept C98274493 @default.
• W4291123360 hasConceptScore W4291123360C104317684 @default.
• W4291123360 hasConceptScore W4291123360C119056186 @default.
• W4291123360 hasConceptScore W4291123360C119157956 @default.
• W4291123360 hasConceptScore W4291123360C126322002 @default.
• W4291123360 hasConceptScore W4291123360C127561419 @default.
• W4291123360 hasConceptScore W4291123360C138488276 @default.
• W4291123360 hasConceptScore W4291123360C17172800 @default.
• W4291123360 hasConceptScore W4291123360C178790620 @default.
• W4291123360 hasConceptScore W4291123360C185592680 @default.
• W4291123360 hasConceptScore W4291123360C203014093 @default.
• W4291123360 hasConceptScore W4291123360C2776914184 @default.
• W4291123360 hasConceptScore W4291123360C2777209026 @default.
• W4291123360 hasConceptScore W4291123360C2780561631 @default.
• W4291123360 hasConceptScore W4291123360C502942594 @default.
• W4291123360 hasConceptScore W4291123360C540031477 @default.
• W4291123360 hasConceptScore W4291123360C541997718 @default.
• W4291123360 hasConceptScore W4291123360C55493867 @default.
• W4291123360 hasConceptScore W4291123360C71924100 @default.

• next