Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291146072> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4291146072 endingPage "925" @default.
- W4291146072 startingPage "921" @default.
- W4291146072 abstract "Introduction Lisdexamfetamine dimesylate (LDX) is a prodrug approved for attention deficit/hyperactivity disorder and for moderate-to-severe binge eating disorder in adults in some countries.Area covered We aimed to specify the abuse potential of LDX in adults, using a review of pharmacokinetic/pharmacodynamic (PK/PD), animal, clinical, and pharmaco-epidemiological studies, through a PubMed search since inception until May 2021 using the following keywords: “lisdexamfetamine AND (‘misuse’ OR ‘abuse’ OR ‘diversion’ OR ‘addiction’)”.Expert opinion Most of the studies highlighted a longer Tmax than dexamphetamine leading to a delayed onset of effects and a decreased Cmax. These PK parameters were often associated with a diminished feeling of euphoria, in comparison to immediate-release dexamphetamine. The potential for abuse was also limited by the prodrug property of LDX, thus reducing the risk of misuse. Nevertheless, all the data were not convergent, as some authors reported similar Cmax for LDX and dexamphetamine and reinforcing properties with a dose-dependent effect. Epidemiological studies found that abuse rates of LDX were substantially lower than those of immediate-release dexamphetamine. Overall, although LDX abuse seems possible, we did not find evidence concerning current safety signal. However, more long-term pharmaco-epidemiological studies are still needed to confirm this finding." @default.
- W4291146072 created "2022-08-13" @default.
- W4291146072 creator A5000507492 @default.
- W4291146072 creator A5010845327 @default.
- W4291146072 creator A5012396192 @default.
- W4291146072 creator A5029511949 @default.
- W4291146072 creator A5033884888 @default.
- W4291146072 creator A5056329559 @default.
- W4291146072 creator A5079465436 @default.
- W4291146072 date "2022-08-03" @default.
- W4291146072 modified "2023-09-30" @default.
- W4291146072 title "What is the potential for abuse of lisdexamfetamine in adults? A preclinical and clinical literature review and expert opinion" @default.
- W4291146072 cites W1963721789 @default.
- W4291146072 cites W1964787897 @default.
- W4291146072 cites W1968014083 @default.
- W4291146072 cites W1974896478 @default.
- W4291146072 cites W1979206088 @default.
- W4291146072 cites W1999725272 @default.
- W4291146072 cites W2011448740 @default.
- W4291146072 cites W2032368646 @default.
- W4291146072 cites W2032877010 @default.
- W4291146072 cites W2064128739 @default.
- W4291146072 cites W2080796480 @default.
- W4291146072 cites W2093104583 @default.
- W4291146072 cites W2115594830 @default.
- W4291146072 cites W2127512142 @default.
- W4291146072 cites W2146886967 @default.
- W4291146072 cites W2165456579 @default.
- W4291146072 cites W2304244843 @default.
- W4291146072 cites W2464300346 @default.
- W4291146072 cites W2588597704 @default.
- W4291146072 cites W2605218699 @default.
- W4291146072 cites W2750699103 @default.
- W4291146072 cites W2777742400 @default.
- W4291146072 cites W2898356502 @default.
- W4291146072 cites W2996408492 @default.
- W4291146072 cites W3016626476 @default.
- W4291146072 cites W3036048791 @default.
- W4291146072 cites W3112949746 @default.
- W4291146072 cites W4245293097 @default.
- W4291146072 cites W777891328 @default.
- W4291146072 doi "https://doi.org/10.1080/17512433.2022.2112950" @default.
- W4291146072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35959655" @default.
- W4291146072 hasPublicationYear "2022" @default.
- W4291146072 type Work @default.
- W4291146072 citedByCount "0" @default.
- W4291146072 crossrefType "journal-article" @default.
- W4291146072 hasAuthorship W4291146072A5000507492 @default.
- W4291146072 hasAuthorship W4291146072A5010845327 @default.
- W4291146072 hasAuthorship W4291146072A5012396192 @default.
- W4291146072 hasAuthorship W4291146072A5029511949 @default.
- W4291146072 hasAuthorship W4291146072A5033884888 @default.
- W4291146072 hasAuthorship W4291146072A5056329559 @default.
- W4291146072 hasAuthorship W4291146072A5079465436 @default.
- W4291146072 hasConcept C118552586 @default.
- W4291146072 hasConcept C38829236 @default.
- W4291146072 hasConcept C48856860 @default.
- W4291146072 hasConcept C71924100 @default.
- W4291146072 hasConcept C98274493 @default.
- W4291146072 hasConceptScore W4291146072C118552586 @default.
- W4291146072 hasConceptScore W4291146072C38829236 @default.
- W4291146072 hasConceptScore W4291146072C48856860 @default.
- W4291146072 hasConceptScore W4291146072C71924100 @default.
- W4291146072 hasConceptScore W4291146072C98274493 @default.
- W4291146072 hasIssue "8" @default.
- W4291146072 hasLocation W42911460721 @default.
- W4291146072 hasLocation W42911460722 @default.
- W4291146072 hasLocation W42911460723 @default.
- W4291146072 hasOpenAccess W4291146072 @default.
- W4291146072 hasPrimaryLocation W42911460721 @default.
- W4291146072 hasRelatedWork W166356027 @default.
- W4291146072 hasRelatedWork W1973445019 @default.
- W4291146072 hasRelatedWork W2037400076 @default.
- W4291146072 hasRelatedWork W2103978020 @default.
- W4291146072 hasRelatedWork W2199132453 @default.
- W4291146072 hasRelatedWork W2271577387 @default.
- W4291146072 hasRelatedWork W2416682262 @default.
- W4291146072 hasRelatedWork W4240432188 @default.
- W4291146072 hasRelatedWork W985168523 @default.
- W4291146072 hasRelatedWork W2185765073 @default.
- W4291146072 hasVolume "15" @default.
- W4291146072 isParatext "false" @default.
- W4291146072 isRetracted "false" @default.
- W4291146072 workType "article" @default.