Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291162273> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4291162273 endingPage "498" @default.
- W4291162273 startingPage "495" @default.
- W4291162273 abstract "High concentration of extracellular ATP acts as a danger signal that is sensed by the P2X7 receptor (P2X7R). This ATP-gated ion channel has been shown to induce multiple metabotropic events such as changes in plasma membrane composition and morphology, ectodomain shedding, activation of lipases, kinases, and transcription factors as well as cytokine release. The specific signaling pathways and molecular mechanisms remain largely obscure. Using an unbiased genome-scale CRISPR/Cas9 screening approach in a murine T cell line, Ryoden et al. (2022, 2020) identified three proteins involved in P2X7 regulation and signaling: Essential for Reactive Oxygen Species (EROS) is essential for P2X7 folding and maturation, and Xk and Vsp13a are required for P2X7-mediated phosphatidyl serine exposure and cell lysis. They further provide evidence for an interaction of Xk and Vsp13a at the plasma membrane and confirm the role of Xk in ATP-induced cytolysis in primary CD25+CD4+ T cells from Xk-/- mice." @default.
- W4291162273 created "2022-08-13" @default.
- W4291162273 creator A5002227918 @default.
- W4291162273 date "2022-08-12" @default.
- W4291162273 modified "2023-10-14" @default.
- W4291162273 title "Identification of novel proteins involved in P2X7-mediated signaling cascades" @default.
- W4291162273 cites W1578475287 @default.
- W4291162273 cites W1968188734 @default.
- W4291162273 cites W1973260880 @default.
- W4291162273 cites W1984648320 @default.
- W4291162273 cites W1994333666 @default.
- W4291162273 cites W2031211461 @default.
- W4291162273 cites W2066171290 @default.
- W4291162273 cites W2108713843 @default.
- W4291162273 cites W2129723413 @default.
- W4291162273 cites W2156638209 @default.
- W4291162273 cites W2224482007 @default.
- W4291162273 cites W2274754252 @default.
- W4291162273 cites W2460383191 @default.
- W4291162273 cites W2603709510 @default.
- W4291162273 cites W2885935758 @default.
- W4291162273 cites W2912196617 @default.
- W4291162273 cites W2940735647 @default.
- W4291162273 cites W2960793673 @default.
- W4291162273 cites W2977373639 @default.
- W4291162273 cites W2994693659 @default.
- W4291162273 cites W3176633792 @default.
- W4291162273 cites W3181271241 @default.
- W4291162273 cites W3201337670 @default.
- W4291162273 cites W3202087824 @default.
- W4291162273 cites W4211131020 @default.
- W4291162273 cites W4291020030 @default.
- W4291162273 cites W4291024566 @default.
- W4291162273 doi "https://doi.org/10.1007/s11302-022-09893-z" @default.
- W4291162273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35960424" @default.
- W4291162273 hasPublicationYear "2022" @default.
- W4291162273 type Work @default.
- W4291162273 citedByCount "0" @default.
- W4291162273 crossrefType "journal-article" @default.
- W4291162273 hasAuthorship W4291162273A5002227918 @default.
- W4291162273 hasBestOaLocation W42911622731 @default.
- W4291162273 hasConcept C1009742 @default.
- W4291162273 hasConcept C170493617 @default.
- W4291162273 hasConcept C185592680 @default.
- W4291162273 hasConcept C55493867 @default.
- W4291162273 hasConcept C62478195 @default.
- W4291162273 hasConcept C86803240 @default.
- W4291162273 hasConcept C95444343 @default.
- W4291162273 hasConceptScore W4291162273C1009742 @default.
- W4291162273 hasConceptScore W4291162273C170493617 @default.
- W4291162273 hasConceptScore W4291162273C185592680 @default.
- W4291162273 hasConceptScore W4291162273C55493867 @default.
- W4291162273 hasConceptScore W4291162273C62478195 @default.
- W4291162273 hasConceptScore W4291162273C86803240 @default.
- W4291162273 hasConceptScore W4291162273C95444343 @default.
- W4291162273 hasFunder F4320323390 @default.
- W4291162273 hasIssue "4" @default.
- W4291162273 hasLocation W42911622731 @default.
- W4291162273 hasLocation W42911622732 @default.
- W4291162273 hasLocation W42911622733 @default.
- W4291162273 hasOpenAccess W4291162273 @default.
- W4291162273 hasPrimaryLocation W42911622731 @default.
- W4291162273 hasRelatedWork W1554961657 @default.
- W4291162273 hasRelatedWork W2014710004 @default.
- W4291162273 hasRelatedWork W2037926784 @default.
- W4291162273 hasRelatedWork W2046666360 @default.
- W4291162273 hasRelatedWork W2064448614 @default.
- W4291162273 hasRelatedWork W2074537257 @default.
- W4291162273 hasRelatedWork W2164357696 @default.
- W4291162273 hasRelatedWork W2479875325 @default.
- W4291162273 hasRelatedWork W4253602782 @default.
- W4291162273 hasRelatedWork W57402234 @default.
- W4291162273 hasVolume "18" @default.
- W4291162273 isParatext "false" @default.
- W4291162273 isRetracted "false" @default.
- W4291162273 workType "article" @default.