FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291169781> ?p ?o ?g. }

• W4291169781 abstract "ABSTRACT Background Recently developed exogenous ketone monoester supplements can acutely raise blood β-OHB and lower blood glucose without the need for other nutritional modifications or invasive procedures. However, unpleasant taste and the potential for gastrointestinal discomfort may make adherence to a supplement regimen challenging. Two novel ketone supplements have been developed that promise an improved consumer experience but differ in their chemical properties; it is currently unknown how these affect blood β-OHB and blood glucose compared to the original ketone monoester supplement. Methods In a double-blind randomized cross-over pilot study, N = 12 healthy individuals (29 ± 5 years, BMI = 25 ± 4 kg/m 2 , 42% female) participated in three experimental trials with a different ketone supplement providing 10 grams of active ingredient in each trial; (i) the monoester (R)-3-hydroxybutyl (R)-3-hydroxybutyrate, (ii) D-β-hydroxybutyric acid with R-1,3-butanediol, and (iii) R-1,3-butanediol. Blood β-OHB and glucose were measured via finger prick capillary blood samples at baseline and across 240 minutes post-supplementation. Supplement acceptability, hunger, and gastrointestinal distress were assessed via questionnaires. Results β-OHB was elevated compared to baseline in all conditions. Total and incremental area under the curve (both p < 0.05) and peak β-OHB ( p < 0.001) differed between conditions with the highest values seen in the ketone monoester condition. Blood glucose concentration was reduced after consumption of each supplement, with no differences in total and incremental area under the curve across supplements. Supplement acceptability was greatest for D-β-hydroxybutyric acid with R-1,3-butanediol, with no effect on hunger or evidence of gastrointestinal distress across all supplements. Conclusions Despite differences in composition, all ketone supplements tested raised β-OHB with the highest values seen after ketone monoester ingestion. Blood glucose was lowered to a similar extent across the assessed time frame with all three supplements." @default.
• W4291169781 created "2022-08-13" @default.
• W4291169781 creator A5000541942 @default.
• W4291169781 creator A5014210997 @default.
• W4291169781 creator A5050121057 @default.
• W4291169781 date "2022-08-12" @default.
• W4291169781 modified "2023-09-30" @default.
• W4291169781 title "The Effect of Novel Exogenous Ketone Supplements on Blood Beta-Hydroxybutyrate and Glucose" @default.
• W4291169781 cites W2007405015 @default.
• W4291169781 cites W2039830331 @default.
• W4291169781 cites W2076054781 @default.
• W4291169781 cites W2157201312 @default.
• W4291169781 cites W2157373911 @default.
• W4291169781 cites W2158025896 @default.
• W4291169781 cites W2171224724 @default.
• W4291169781 cites W2411839522 @default.
• W4291169781 cites W2563861885 @default.
• W4291169781 cites W2739936777 @default.
• W4291169781 cites W2761703425 @default.
• W4291169781 cites W3005470332 @default.
• W4291169781 cites W4225923924 @default.
• W4291169781 cites W4256017688 @default.
• W4291169781 doi "https://doi.org/10.1101/2022.08.11.22278668" @default.
• W4291169781 hasPublicationYear "2022" @default.
• W4291169781 type Work @default.
• W4291169781 citedByCount "0" @default.
• W4291169781 crossrefType "posted-content" @default.
• W4291169781 hasAuthorship W4291169781A5000541942 @default.
• W4291169781 hasAuthorship W4291169781A5014210997 @default.
• W4291169781 hasAuthorship W4291169781A5050121057 @default.
• W4291169781 hasBestOaLocation W42911697811 @default.
• W4291169781 hasConcept C126322002 @default.
• W4291169781 hasConcept C134018914 @default.
• W4291169781 hasConcept C178790620 @default.
• W4291169781 hasConcept C185592680 @default.
• W4291169781 hasConcept C2776731943 @default.
• W4291169781 hasConcept C2777738585 @default.
• W4291169781 hasConcept C2781413609 @default.
• W4291169781 hasConcept C31532488 @default.
• W4291169781 hasConcept C555293320 @default.
• W4291169781 hasConcept C62231903 @default.
• W4291169781 hasConcept C71924100 @default.
• W4291169781 hasConceptScore W4291169781C126322002 @default.
• W4291169781 hasConceptScore W4291169781C134018914 @default.
• W4291169781 hasConceptScore W4291169781C178790620 @default.
• W4291169781 hasConceptScore W4291169781C185592680 @default.
• W4291169781 hasConceptScore W4291169781C2776731943 @default.
• W4291169781 hasConceptScore W4291169781C2777738585 @default.
• W4291169781 hasConceptScore W4291169781C2781413609 @default.
• W4291169781 hasConceptScore W4291169781C31532488 @default.
• W4291169781 hasConceptScore W4291169781C555293320 @default.
• W4291169781 hasConceptScore W4291169781C62231903 @default.
• W4291169781 hasConceptScore W4291169781C71924100 @default.
• W4291169781 hasLocation W42911697811 @default.
• W4291169781 hasOpenAccess W4291169781 @default.
• W4291169781 hasPrimaryLocation W42911697811 @default.
• W4291169781 hasRelatedWork W1825631347 @default.
• W4291169781 hasRelatedWork W2060917165 @default.
• W4291169781 hasRelatedWork W2312218942 @default.
• W4291169781 hasRelatedWork W2346524513 @default.
• W4291169781 hasRelatedWork W2351557628 @default.
• W4291169781 hasRelatedWork W2365235867 @default.
• W4291169781 hasRelatedWork W2370378779 @default.
• W4291169781 hasRelatedWork W2428820893 @default.
• W4291169781 hasRelatedWork W3133723034 @default.
• W4291169781 hasRelatedWork W4247989261 @default.
• W4291169781 isParatext "false" @default.
• W4291169781 isRetracted "false" @default.
• W4291169781 workType "article" @default.