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- W4291183994 endingPage "101038" @default.
- W4291183994 startingPage "101038" @default.
- W4291183994 abstract "The SARS-CoV-2 virus causes Coronavirus disease, an infectious disease. The majority of people who are infected with this virus will have mild to moderate respiratory symptoms. Multiple studies have proved that there is a substantial pathophysiological link between COVID-19 disease and patients having comorbidities such as cystic fibrosis and chronic kidney disease. In this study, we attempted to identify differentially expressed genes as well as genes that intersected among them in order to comprehend their compatibility. Gene expression profiling indicated that 849 genes were mutually exclusive and functional analysis was done within the context of gene ontology and key pathways involvement. Three genes (PRPF31, FOXN2, and RIOK3) were commonly upregulated in the analysed datasets of three disease categories. These genes could be potential biomarkers for patients with COVID-19 and cystic fibrosis, and COVID-19 and chronic kidney disease. Further extensive analyses have been performed to describe how these genes are regulated by various transcription factors and microRNAs. Then, our analyses revealed six hub genes (PRPF31, FOXN2, RIOK3, UBC, HNF4A, and ELAVL). As they were involved in the interaction between COVID-19 and the patient with CF and CKD, they could help researchers identify potential therapeutic molecules. Some drugs have been predicted based on the upregulated genes, which may have a significant impact on reducing the burden of these diseases in the future." @default.
- W4291183994 created "2022-08-13" @default.
- W4291183994 creator A5029300178 @default.
- W4291183994 creator A5051165348 @default.
- W4291183994 date "2022-01-01" @default.
- W4291183994 modified "2023-10-14" @default.
- W4291183994 title "Identification of differentially expressed genes and their major pathways among the patient with COVID-19, cystic fibrosis, and chronic kidney disease" @default.
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- W4291183994 doi "https://doi.org/10.1016/j.imu.2022.101038" @default.
- W4291183994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35966126" @default.
- W4291183994 hasPublicationYear "2022" @default.
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