FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291227801> ?p ?o ?g. }

• W4291227801 endingPage "114104" @default.
• W4291227801 startingPage "114104" @default.
• W4291227801 abstract "High-fat diet (HFD) affects the physiology of reproduction in males, and many studies have investigated its detrimental effects. In this study, we investigated the cellular response induced by an HFD in the rat testis, focusing on the mitochondrial compartment. After five weeks of HFD, an increase in the levels of malondialdehyde and of reduced form of glutathione in the rat testis indicated an increase in lipid peroxidation. The results showed an increase in autophagy, apoptosis, and mitochondrial damage in the testis of HFD rats. We found a decrease in the protein expression of mitochondrial antioxidant enzymes, such as catalase and SOD2. Immunohistochemical analysis revealed a decrease in the immunofluorescent signal of SOD2, mainly in the spermatogonia and spermatocytes of HFD rats. HFD-induced mitochondrial damage caused a reduction in mitochondria, as evidenced by a decrease in the protein expression of TOM20, a mitochondrial outer membrane receptor. Consistently, HFD enhanced the levels of the PINK1 protein, a mitophagy marker, suggesting the removal of damaged mitochondria under these conditions. Induction of mtDNA damage and repair was stronger in the HFD rat testis. Finally, we found a decrease in the mtDNA copy number and expression of the POLG enzyme, which is involved in mtDNA replication. In conclusion, our results showed that autophagy and apoptosis are activated in the testis of HFD rats as a survival strategy to cope with oxidative stress. Furthermore, HFD-induced oxidative stress affects the mitochondria, inducing mtDNA damage and mtDNA copy number reduction. Mitophagy and mtDNA repair mechanisms might represent a mitochondrial adaptive response." @default.
• W4291227801 created "2022-08-13" @default.
• W4291227801 creator A5004291971 @default.
• W4291227801 creator A5036786223 @default.
• W4291227801 creator A5058443329 @default.
• W4291227801 creator A5068046728 @default.
• W4291227801 creator A5071221529 @default.
• W4291227801 creator A5079147169 @default.
• W4291227801 creator A5081350847 @default.
• W4291227801 date "2022-11-01" @default.
• W4291227801 modified "2023-10-13" @default.
• W4291227801 title "Autophagy and mitochondrial damage in the testis of high-fat diet fed rats" @default.
• W4291227801 cites W1969690844 @default.
• W4291227801 cites W1978764742 @default.
• W4291227801 cites W2001248597 @default.
• W4291227801 cites W2001675597 @default.
• W4291227801 cites W2004257622 @default.
• W4291227801 cites W2014178880 @default.
• W4291227801 cites W2014192887 @default.
• W4291227801 cites W2028661305 @default.
• W4291227801 cites W2039820453 @default.
• W4291227801 cites W2058232753 @default.
• W4291227801 cites W2065801092 @default.
• W4291227801 cites W2072898133 @default.
• W4291227801 cites W2084065253 @default.
• W4291227801 cites W2092699248 @default.
• W4291227801 cites W2094463280 @default.
• W4291227801 cites W2094947007 @default.
• W4291227801 cites W2095987251 @default.
• W4291227801 cites W2104109524 @default.
• W4291227801 cites W2136686852 @default.
• W4291227801 cites W2152193086 @default.
• W4291227801 cites W2153360225 @default.
• W4291227801 cites W2158173525 @default.
• W4291227801 cites W2171813756 @default.
• W4291227801 cites W2409245484 @default.
• W4291227801 cites W2520306567 @default.
• W4291227801 cites W2594567044 @default.
• W4291227801 cites W2600742684 @default.
• W4291227801 cites W2767907425 @default.
• W4291227801 cites W2789860421 @default.
• W4291227801 cites W2888153698 @default.
• W4291227801 cites W2936446594 @default.
• W4291227801 cites W2954231086 @default.
• W4291227801 cites W2964863881 @default.
• W4291227801 cites W2969880588 @default.
• W4291227801 cites W2979094705 @default.
• W4291227801 cites W3019879636 @default.
• W4291227801 cites W3022611812 @default.
• W4291227801 cites W3025742621 @default.
• W4291227801 cites W3027069734 @default.
• W4291227801 cites W3092107442 @default.
• W4291227801 cites W3120660874 @default.
• W4291227801 cites W3121008513 @default.
• W4291227801 cites W3147644396 @default.
• W4291227801 cites W4200462472 @default.
• W4291227801 cites W4206665447 @default.
• W4291227801 cites W4211176768 @default.
• W4291227801 doi "https://doi.org/10.1016/j.ygcen.2022.114104" @default.
• W4291227801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35973585" @default.
• W4291227801 hasPublicationYear "2022" @default.
• W4291227801 type Work @default.
• W4291227801 citedByCount "2" @default.
• W4291227801 countsByYear W42912278012023 @default.
• W4291227801 crossrefType "journal-article" @default.
• W4291227801 hasAuthorship W4291227801A5004291971 @default.
• W4291227801 hasAuthorship W4291227801A5036786223 @default.
• W4291227801 hasAuthorship W4291227801A5058443329 @default.
• W4291227801 hasAuthorship W4291227801A5068046728 @default.
• W4291227801 hasAuthorship W4291227801A5071221529 @default.
• W4291227801 hasAuthorship W4291227801A5079147169 @default.
• W4291227801 hasAuthorship W4291227801A5081350847 @default.
• W4291227801 hasConcept C104317684 @default.
• W4291227801 hasConcept C126322002 @default.
• W4291227801 hasConcept C134018914 @default.
• W4291227801 hasConcept C169415338 @default.
• W4291227801 hasConcept C190283241 @default.
• W4291227801 hasConcept C203522944 @default.
• W4291227801 hasConcept C24586158 @default.
• W4291227801 hasConcept C2775838275 @default.
• W4291227801 hasConcept C2776108821 @default.
• W4291227801 hasConcept C2776151105 @default.
• W4291227801 hasConcept C2776804853 @default.
• W4291227801 hasConcept C2777229759 @default.
• W4291227801 hasConcept C2778918659 @default.
• W4291227801 hasConcept C2779324830 @default.
• W4291227801 hasConcept C2781302388 @default.
• W4291227801 hasConcept C28859421 @default.
• W4291227801 hasConcept C41625074 @default.
• W4291227801 hasConcept C55493867 @default.
• W4291227801 hasConcept C71924100 @default.
• W4291227801 hasConcept C86803240 @default.
• W4291227801 hasConcept C95444343 @default.
• W4291227801 hasConceptScore W4291227801C104317684 @default.
• W4291227801 hasConceptScore W4291227801C126322002 @default.
• W4291227801 hasConceptScore W4291227801C134018914 @default.
• W4291227801 hasConceptScore W4291227801C169415338 @default.
• W4291227801 hasConceptScore W4291227801C190283241 @default.

• next