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- W4291279185 abstract "Abstract We demonstrate here a single-step and user-friendly approach to generate insulin producing cells by gRNA driven specific-activation of PDX1, NKX6.1, MAFA, Insulin and Glut2 genes in somatic cells via multiplex-epigenetic-engineering-vector (MEEV-β) containing dCas9.P300 core developed by us. Sorted Glut2 + cells could secrete insulin in response to glucose challenge and showed expression of β-cell specific transcription factors: NKX2.2, and aforementioned genes. Expression of Cav1.3, GSK3β,, KJNC11, and SLC30A8 genes substantiated the functional insulin secreting machinery genes in these Glut2 + cells. Also, absence of ARX and GCG expression in these cells highlighted the specificity of the conversion." @default.
- W4291279185 created "2022-08-14" @default.
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- W4291279185 date "2022-08-13" @default.
- W4291279185 modified "2023-09-23" @default.
- W4291279185 title "Direct conversion of somatic cells into ‘insulin-producing-cells’ by user-defined multiplex-epigenetic-engineering vector (MEEV-β)" @default.
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- W4291279185 doi "https://doi.org/10.1101/2022.08.12.503816" @default.
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