FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291283359> ?p ?o ?g. }

• W4291283359 endingPage "5049" @default.
• W4291283359 startingPage "5040" @default.
• W4291283359 abstract "Among various glioma types, glioblastoma multiforme (GBM) is one of those with the highest malignancy. Although overexpression of eukaryotic translation initiation factor 6 (eIF6), a factor that regulates protein translation initiation, is believed to promote tumor development, its function and potential molecular mechanisms in glioma progression remain uncharacterized. Consequently, we evaluated its diagnostic and prognostic utility in GBM patients.Sample data from two databases, The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA), were utilized to investigate the role of eIF6 as well as its mechanism of action in gliomas. We analyzed eIF6 expression in normal tissues as well as cancerous samples of different stages of glioma. The diagnostic and prognostic value of eIF6 were analyzed using the Receiver Operating Characteristic Curve (ROC) and Kaplan-Meier analysis, respectively. Furthermore, its underlying molecular mechanism in GBM was further revealed by gene set enrichment analysis (GSEA).Transcriptome data analyses of the two databases showed that eIF6 was upregulated in glioma tissues compared with normal counterparts. eIF6 was at high levels in WHO grade IV gliomas versus grade II and III gliomas (P<0.05). In addition, eIF6 was highly expressed in elderly and Asian glioma patients. Furthermore, eIF6 expression was found to be lower in isocitrate dehydrogenase (IDH)-mutated tumors. Patients with high eIF6 level presented shorter overall survival than cases with low eIF6 level (P<0.05), and eIF6 had favorable accuracy in predicting the prognosis of glioma patients. GSEA revealed that high eIF6 expression was mainly concentrated in cell cycle and DNA repair related pathways.eIF6 is highly expressed in gliomas and positively associated with the degree of malignancy. Patients with high eIF6 expression present poor survival. Therefore, eIF6 has the potential to be a diagnostic biomarker and a potential therapeutic target for glioma development and GBM." @default.
• W4291283359 created "2022-08-14" @default.
• W4291283359 creator A5011877804 @default.
• W4291283359 creator A5025751238 @default.
• W4291283359 creator A5036003356 @default.
• W4291283359 creator A5046733331 @default.
• W4291283359 creator A5047869791 @default.
• W4291283359 creator A5070607262 @default.
• W4291283359 creator A5086747214 @default.
• W4291283359 date "2022-01-01" @default.
• W4291283359 modified "2023-10-17" @default.
• W4291283359 title "Diagnostic and prognostic utility of eIF6 in glioblastoma: a study based on TCGA and CGGA databases." @default.
• W4291283359 cites W1971543885 @default.
• W4291283359 cites W2005661588 @default.
• W4291283359 cites W2053183259 @default.
• W4291283359 cites W2055018340 @default.
• W4291283359 cites W2061835124 @default.
• W4291283359 cites W2068060315 @default.
• W4291283359 cites W2069683615 @default.
• W4291283359 cites W2087401839 @default.
• W4291283359 cites W2091465204 @default.
• W4291283359 cites W2091885719 @default.
• W4291283359 cites W2093750110 @default.
• W4291283359 cites W2098341282 @default.
• W4291283359 cites W2116485123 @default.
• W4291283359 cites W2121022376 @default.
• W4291283359 cites W2130511906 @default.
• W4291283359 cites W2134807618 @default.
• W4291283359 cites W2148977460 @default.
• W4291283359 cites W2273444055 @default.
• W4291283359 cites W2293496672 @default.
• W4291283359 cites W2341890933 @default.
• W4291283359 cites W2372854826 @default.
• W4291283359 cites W2735151471 @default.
• W4291283359 cites W2751117865 @default.
• W4291283359 cites W2792107889 @default.
• W4291283359 cites W2887389613 @default.
• W4291283359 cites W2914942635 @default.
• W4291283359 cites W2951192083 @default.
• W4291283359 cites W2956140188 @default.
• W4291283359 cites W3032492761 @default.
• W4291283359 cites W3080516258 @default.
• W4291283359 cites W3136730222 @default.
• W4291283359 cites W3161100926 @default.
• W4291283359 cites W3161813768 @default.
• W4291283359 cites W4206019653 @default.
• W4291283359 cites W4226366076 @default.
• W4291283359 cites W4244344354 @default.
• W4291283359 cites W2905387056 @default.
• W4291283359 cites W2992449806 @default.
• W4291283359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35958479" @default.
• W4291283359 hasPublicationYear "2022" @default.
• W4291283359 type Work @default.
• W4291283359 citedByCount "0" @default.
• W4291283359 crossrefType "journal-article" @default.
• W4291283359 hasAuthorship W4291283359A5011877804 @default.
• W4291283359 hasAuthorship W4291283359A5025751238 @default.
• W4291283359 hasAuthorship W4291283359A5036003356 @default.
• W4291283359 hasAuthorship W4291283359A5046733331 @default.
• W4291283359 hasAuthorship W4291283359A5047869791 @default.
• W4291283359 hasAuthorship W4291283359A5070607262 @default.
• W4291283359 hasAuthorship W4291283359A5086747214 @default.
• W4291283359 hasConcept C104317684 @default.
• W4291283359 hasConcept C150194340 @default.
• W4291283359 hasConcept C162317418 @default.
• W4291283359 hasConcept C181199279 @default.
• W4291283359 hasConcept C2777150147 @default.
• W4291283359 hasConcept C2778227246 @default.
• W4291283359 hasConcept C2779399171 @default.
• W4291283359 hasConcept C502942594 @default.
• W4291283359 hasConcept C54355233 @default.
• W4291283359 hasConcept C55493867 @default.
• W4291283359 hasConcept C86803240 @default.
• W4291283359 hasConceptScore W4291283359C104317684 @default.
• W4291283359 hasConceptScore W4291283359C150194340 @default.
• W4291283359 hasConceptScore W4291283359C162317418 @default.
• W4291283359 hasConceptScore W4291283359C181199279 @default.
• W4291283359 hasConceptScore W4291283359C2777150147 @default.
• W4291283359 hasConceptScore W4291283359C2778227246 @default.
• W4291283359 hasConceptScore W4291283359C2779399171 @default.
• W4291283359 hasConceptScore W4291283359C502942594 @default.
• W4291283359 hasConceptScore W4291283359C54355233 @default.
• W4291283359 hasConceptScore W4291283359C55493867 @default.
• W4291283359 hasConceptScore W4291283359C86803240 @default.
• W4291283359 hasIssue "7" @default.
• W4291283359 hasLocation W42912833591 @default.
• W4291283359 hasOpenAccess W4291283359 @default.
• W4291283359 hasPrimaryLocation W42912833591 @default.
• W4291283359 hasRelatedWork W2070897281 @default.
• W4291283359 hasRelatedWork W2117996853 @default.
• W4291283359 hasRelatedWork W2891407968 @default.
• W4291283359 hasRelatedWork W2899083722 @default.
• W4291283359 hasRelatedWork W3031527645 @default.
• W4291283359 hasRelatedWork W3158283057 @default.
• W4291283359 hasRelatedWork W3158729267 @default.
• W4291283359 hasRelatedWork W4212825821 @default.
• W4291283359 hasRelatedWork W4226156414 @default.
• W4291283359 hasRelatedWork W984969756 @default.

• next