FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291283682> ?p ?o ?g. }

• W4291283682 abstract "Abstract Background Spatial transcriptomics (ST) combines stained tissue images with spatially resolved high-throughput RNA sequencing. The spatial transcriptomic analysis includes challenging tasks like clustering, where a partition among data points (spots) is defined by means of a similarity measure. Improving clustering results is a key factor as clustering affects subsequent downstream analysis. State-of-the-art approaches group data by taking into account transcriptional similarity and some by exploiting spatial information as well. However, it is not yet clear how much the spatial information combined with transcriptomics improves the clustering result. Results We propose a new clustering method, Stardust, that easily exploits the combination of space and transcriptomic information in the clustering procedure through a manual or fully automatic tuning of algorithm parameters. Moreover, a parameter-free version of the method is also provided where the spatial contribution depends dynamically on the expression distances distribution in the space. We evaluated the proposed methods results by analyzing ST data sets available on the 10x Genomics website and comparing clustering performances with state-of-the-art approaches by measuring the spots' stability in the clusters and their biological coherence. Stability is defined by the tendency of each point to remain clustered with the same neighbors when perturbations are applied. Conclusions Stardust is an easy-to-use methodology allowing to define how much spatial information should influence clustering on different tissues and achieving more stable results than state-of-the-art approaches." @default.
• W4291283682 created "2022-08-14" @default.
• W4291283682 creator A5002057785 @default.
• W4291283682 creator A5002392135 @default.
• W4291283682 creator A5025014550 @default.
• W4291283682 creator A5031882928 @default.
• W4291283682 creator A5035509473 @default.
• W4291283682 creator A5058272351 @default.
• W4291283682 creator A5058658234 @default.
• W4291283682 creator A5066425280 @default.
• W4291283682 date "2022-01-01" @default.
• W4291283682 modified "2023-10-10" @default.
• W4291283682 title "<i>Stardust</i>: improving spatial transcriptomics data analysis through space-aware modularity optimization-based clustering" @default.
• W4291283682 cites W2010653277 @default.
• W4291283682 cites W2131681506 @default.
• W4291283682 cites W2295124130 @default.
• W4291283682 cites W2471536144 @default.
• W4291283682 cites W2786029688 @default.
• W4291283682 cites W2794480084 @default.
• W4291283682 cites W2949177718 @default.
• W4291283682 cites W2971877487 @default.
• W4291283682 cites W3021920958 @default.
• W4291283682 cites W3108118546 @default.
• W4291283682 cites W3119379269 @default.
• W4291283682 cites W3129476455 @default.
• W4291283682 cites W3134482219 @default.
• W4291283682 cites W3165120573 @default.
• W4291283682 cites W3167327839 @default.
• W4291283682 cites W3181253984 @default.
• W4291283682 cites W3190202966 @default.
• W4291283682 cites W3191029526 @default.
• W4291283682 cites W3191824479 @default.
• W4291283682 cites W3203128182 @default.
• W4291283682 cites W3204015056 @default.
• W4291283682 cites W4291283682 @default.
• W4291283682 doi "https://doi.org/10.1093/gigascience/giac075" @default.
• W4291283682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35946989" @default.
• W4291283682 hasPublicationYear "2022" @default.
• W4291283682 type Work @default.
• W4291283682 citedByCount "3" @default.
• W4291283682 countsByYear W42912836822022 @default.
• W4291283682 countsByYear W42912836822023 @default.
• W4291283682 crossrefType "journal-article" @default.
• W4291283682 hasAuthorship W4291283682A5002057785 @default.
• W4291283682 hasAuthorship W4291283682A5002392135 @default.
• W4291283682 hasAuthorship W4291283682A5025014550 @default.
• W4291283682 hasAuthorship W4291283682A5031882928 @default.
• W4291283682 hasAuthorship W4291283682A5035509473 @default.
• W4291283682 hasAuthorship W4291283682A5058272351 @default.
• W4291283682 hasAuthorship W4291283682A5058658234 @default.
• W4291283682 hasAuthorship W4291283682A5066425280 @default.
• W4291283682 hasBestOaLocation W42912836821 @default.
• W4291283682 hasConcept C103278499 @default.
• W4291283682 hasConcept C105795698 @default.
• W4291283682 hasConcept C114614502 @default.
• W4291283682 hasConcept C115961682 @default.
• W4291283682 hasConcept C124101348 @default.
• W4291283682 hasConcept C153180895 @default.
• W4291283682 hasConcept C154945302 @default.
• W4291283682 hasConcept C159620131 @default.
• W4291283682 hasConcept C17212007 @default.
• W4291283682 hasConcept C186767784 @default.
• W4291283682 hasConcept C33704608 @default.
• W4291283682 hasConcept C33923547 @default.
• W4291283682 hasConcept C36464697 @default.
• W4291283682 hasConcept C41008148 @default.
• W4291283682 hasConcept C42812 @default.
• W4291283682 hasConcept C73555534 @default.
• W4291283682 hasConceptScore W4291283682C103278499 @default.
• W4291283682 hasConceptScore W4291283682C105795698 @default.
• W4291283682 hasConceptScore W4291283682C114614502 @default.
• W4291283682 hasConceptScore W4291283682C115961682 @default.
• W4291283682 hasConceptScore W4291283682C124101348 @default.
• W4291283682 hasConceptScore W4291283682C153180895 @default.
• W4291283682 hasConceptScore W4291283682C154945302 @default.
• W4291283682 hasConceptScore W4291283682C159620131 @default.
• W4291283682 hasConceptScore W4291283682C17212007 @default.
• W4291283682 hasConceptScore W4291283682C186767784 @default.
• W4291283682 hasConceptScore W4291283682C33704608 @default.
• W4291283682 hasConceptScore W4291283682C33923547 @default.
• W4291283682 hasConceptScore W4291283682C36464697 @default.
• W4291283682 hasConceptScore W4291283682C41008148 @default.
• W4291283682 hasConceptScore W4291283682C42812 @default.
• W4291283682 hasConceptScore W4291283682C73555534 @default.
• W4291283682 hasLocation W42912836821 @default.
• W4291283682 hasLocation W42912836822 @default.
• W4291283682 hasLocation W42912836823 @default.
• W4291283682 hasLocation W42912836824 @default.
• W4291283682 hasOpenAccess W4291283682 @default.
• W4291283682 hasPrimaryLocation W42912836821 @default.
• W4291283682 hasRelatedWork W1490108905 @default.
• W4291283682 hasRelatedWork W2118211060 @default.
• W4291283682 hasRelatedWork W2128921268 @default.
• W4291283682 hasRelatedWork W2289971201 @default.
• W4291283682 hasRelatedWork W2398543122 @default.
• W4291283682 hasRelatedWork W2525029050 @default.
• W4291283682 hasRelatedWork W2624823234 @default.
• W4291283682 hasRelatedWork W2626264717 @default.
• W4291283682 hasRelatedWork W3192757256 @default.
• W4291283682 hasRelatedWork W4367321730 @default.

• next