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• W4291287665 abstract "Summary In prion diseases, fibrillar assemblies of misfolded prion protein (PrP) self-propagate by incorporating PrP monomers. Using total internal reflection and transient amyloid binding super-resolution microscopy, our study analyses elongation of single PrP fibrils to reveal polymorphic populations, featuring structural and dynamic heterogeneity similar to prion strains, which were previously hidden in ensemble measurements. PrP fibrils elongated along a preferred direction by an intermittent ‘stop- and-go’ mechanism. Fibrils fell into three main populations, which each displayed distinct elongation mechanisms incorporating different monomer structures and which maintained their properties even under elongation conditions favouring a different fibril type. Elongation of RML and ME7 prion rods likewise exhibited unique kinetic features. The discovery of polymorphic fibril populations of amyloid and prions growing in competition suggests that prions may present as quasispecies of structural isomorphs and that the replication environment may tilt the balance between prion isomorphs and amyloid species. Highlights Synthetic prion fibril populations contain structurally distinct fibril types Fibril types faithfully elongate by different mechanisms Fibril types compete for substrate depending on environment Fibril populations model quasi-species behavior of prion strains eTOC Replication of different prion strains causes distinct disease phenotypes. Sun et al. analyzed the growth of individual synthetic prion protein fibrils by super-resolution microscopy and found populations of structurally distinct fibril types, which grew in competition to each other as a quasi-species, recapitulating basic prion strain characteristics in vitro ." @default.
• W4291287665 created "2022-08-14" @default.
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• W4291287665 date "2022-08-13" @default.
• W4291287665 modified "2023-09-26" @default.
• W4291287665 title "Direct Observation of Competing Prion Protein Fibril Populations with Distinct Structures and Kinetics" @default.
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• W4291287665 doi "https://doi.org/10.1101/2022.08.10.503301" @default.
• W4291287665 hasPublicationYear "2022" @default.
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