FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291291231> ?p ?o ?g. }

• W4291291231 endingPage "S55" @default.
• W4291291231 startingPage "S55" @default.
• W4291291231 abstract "Despite increasing debates about their potential side effects on human health, data on the risks and impacts associated with pesticides is scarce and fragmented. There is a need for analytical tools for the measurement of most pesticides and/or their metabolites to which the population might be exposed. In this study, we present both untargeted and targeted Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS) screenings, suitable for the determination of pesticides in serum. We included 205 pesticides and metabolites of interest, comprising among others carbamates, dithiocarbamates, neonicotinoids, organochlorines, organophosphates and pyrethroids. A QuEChERS salt extraction was applied and chromatographic separation was performed in a biphenyl 2.7 μm (100 × 2.1 mm I.D.) column. For the HRMS acquisition, a Q-TOF (LCMS-9030®, Shimadzu) was used. Data was acquired either with an untargeted (Data independant acquisition, DIA), or targeted acquisition mode (HR-MS/MS). For each molecule, we determined the limit of detection (LOD) in a calibration range between 0.05 and 10 ng/mL. The procedure was applied to 62 patient serum samples. Results were then compared with those of a classical Multiple reaction Monitoring (MRM) LC-MS/MS screening method based on a low resolution acquisition (triple quadrupole; LCMS-8060®, Shimadzu). Six calibration curves (on 6 different days) revealed that about 99% of the compounds exhibited a LOD≤5 ng/mL for both targeted and untargeted screenings. For about 2 thirds of the molecules (66% and 68%, respectively), LOD was ≤0.5 ng/mL. For about one quarter of them (22% and 26%, respectively) LOD≤0.1 ng/mL. Out of the 62 serum samples, 79 compounds (22 different pesticides and metabolites) were detected by LC-HRMS. At very low LOD (<0.05 ng/mL), only 7 additional compounds could be detected using the low resolution approach. We developed highly sensitive LC-HRMS screening methods allowing the detection of a large panel of pesticides considered responsible for environmental and occupational exposure. Some compounds however remain inaccessible to LC and require GC analysis demonstrating the need to combine analytical techniques to gain a better understanding of population exposure to pesticides." @default.
• W4291291231 created "2022-08-14" @default.
• W4291291231 creator A5013145133 @default.
• W4291291231 creator A5022711298 @default.
• W4291291231 creator A5048157334 @default.
• W4291291231 creator A5088113195 @default.
• W4291291231 date "2022-09-01" @default.
• W4291291231 modified "2023-10-05" @default.
• W4291291231 title "Quantitative screening of pesticides and their metabolites in human matrices: Are we ready to switch to high resolution mass spectrometry?" @default.
• W4291291231 doi "https://doi.org/10.1016/j.toxac.2022.06.067" @default.
• W4291291231 hasPublicationYear "2022" @default.
• W4291291231 type Work @default.
• W4291291231 citedByCount "0" @default.
• W4291291231 crossrefType "journal-article" @default.
• W4291291231 hasAuthorship W4291291231A5013145133 @default.
• W4291291231 hasAuthorship W4291291231A5022711298 @default.
• W4291291231 hasAuthorship W4291291231A5048157334 @default.
• W4291291231 hasAuthorship W4291291231A5088113195 @default.
• W4291291231 hasBestOaLocation W42912912311 @default.
• W4291291231 hasConcept C106848363 @default.
• W4291291231 hasConcept C119128265 @default.
• W4291291231 hasConcept C161176658 @default.
• W4291291231 hasConcept C162356407 @default.
• W4291291231 hasConcept C172493649 @default.
• W4291291231 hasConcept C185592680 @default.
• W4291291231 hasConcept C23531484 @default.
• W4291291231 hasConcept C2775926907 @default.
• W4291291231 hasConcept C31827203 @default.
• W4291291231 hasConcept C43617362 @default.
• W4291291231 hasConcept C6557445 @default.
• W4291291231 hasConcept C71043704 @default.
• W4291291231 hasConcept C86803240 @default.
• W4291291231 hasConceptScore W4291291231C106848363 @default.
• W4291291231 hasConceptScore W4291291231C119128265 @default.
• W4291291231 hasConceptScore W4291291231C161176658 @default.
• W4291291231 hasConceptScore W4291291231C162356407 @default.
• W4291291231 hasConceptScore W4291291231C172493649 @default.
• W4291291231 hasConceptScore W4291291231C185592680 @default.
• W4291291231 hasConceptScore W4291291231C23531484 @default.
• W4291291231 hasConceptScore W4291291231C2775926907 @default.
• W4291291231 hasConceptScore W4291291231C31827203 @default.
• W4291291231 hasConceptScore W4291291231C43617362 @default.
• W4291291231 hasConceptScore W4291291231C6557445 @default.
• W4291291231 hasConceptScore W4291291231C71043704 @default.
• W4291291231 hasConceptScore W4291291231C86803240 @default.
• W4291291231 hasIssue "3" @default.
• W4291291231 hasLocation W42912912311 @default.
• W4291291231 hasOpenAccess W4291291231 @default.
• W4291291231 hasPrimaryLocation W42912912311 @default.
• W4291291231 hasRelatedWork W1512590817 @default.
• W4291291231 hasRelatedWork W1916024577 @default.
• W4291291231 hasRelatedWork W2003020830 @default.
• W4291291231 hasRelatedWork W2090990910 @default.
• W4291291231 hasRelatedWork W2187782066 @default.
• W4291291231 hasRelatedWork W2198245078 @default.
• W4291291231 hasRelatedWork W2364645860 @default.
• W4291291231 hasRelatedWork W2936951805 @default.
• W4291291231 hasRelatedWork W3120243476 @default.
• W4291291231 hasRelatedWork W2370467352 @default.
• W4291291231 hasVolume "34" @default.
• W4291291231 isParatext "false" @default.
• W4291291231 isRetracted "false" @default.
• W4291291231 workType "article" @default.