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- W4291291346 abstract "to determine some pharmacokinetic parameters in mice after oral and IV administrations of hydroalcoholic extract of Nerium oleander. Pharmacokinetic studies of oleandrin, a cardiotonic glycoside and main active compound of Nerium oleander were conducted in mice after administration of an IV dose (30 mg/kg) and a PO dose (150 mg/kg) of an hydrolcoholic extract of Nerium oleander. Oleandrin was measured by LC-MS/MS. oleandrin was rapidly absorbed after oral administration (Cmax at 10 min). The AUC0-inf (ug/L*min) values obtained after IV and PO dosing were 34,797.7 and 107,222, respectively, resulting in an oral bioavailability of 61.6%. The apparent volume of distribution Vss was 0.55 L/kg and clearance ClT was 0.01 kg* L/min. Further studies are needed, to elicit the pharmacokinetic parameters of oleandrin after various routes of administration, in multiple species, multiple doses et and different preparations." @default.
- W4291291346 created "2022-08-14" @default.
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- W4291291346 date "2022-09-01" @default.
- W4291291346 modified "2023-10-05" @default.
- W4291291346 title "Pharmacokinetics of oleandrin after administration of a Nerium oleander extract in mice" @default.
- W4291291346 doi "https://doi.org/10.1016/j.toxac.2022.06.130" @default.
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