FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291291546> ?p ?o ?g. }

• W4291291546 endingPage "S31" @default.
• W4291291546 startingPage "S31" @default.
• W4291291546 abstract "The continual emergence of new psychoactive substances remains a global health issue. We reported a case of serotoninergic syndrome following the consumption of 3,4-methylenedioxy-α-pyrrolidinohexanophenone (MDPHP) and 25H-NBOH documented by liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS). A 23-year-old man, with a history of cathinone regular use, presented a seizure and a loss of consciousness 30 min after the consumption of a powder identified as 25I-NBOH. The way of exposure was not documented. On arrival at the mobile emergency unit, the patient exhibited a serotonin syndrome with hyperthermia at 41 °C, hypertonia of the upper limbs, bilateral mydriasis, Glasgow coma 3, hypertension at 16/8, tachycardia at 180 bpm, and SaO2 = 50%. During the hospitalization, he developped acute renal failure, acute liver failure, rhabdomyolysis and disseminated intravascular coagulation. He was discharged after 20 days of hospitalization but kept neurological sequelae. Following his hospital admission, blood and urine samples were drawn and sent to the toxicology laboratory to determine the cause of poisoning. In total, 200 μL of plasma and urine samples were extracted with QuEChERS salts and acetonitrile. The extracts were analyzed by liquid chromatography hyphenated to high-resolution mass spectrometry (Orbitrap, Exploris 120) allowing both a non-targeted screening and the simultaneous quantification of 132 compounds frequently found in poisonings. Analysis was realized in full scan experiment with a nominal resolving power of 60,000 FWHM within the 125–650 m/z mass range, followed by four cycles of DDA with a mass resolution of 16,000 FWHM. Pharmaceuticals administered to the patient during his medical care were found in plasma and urine: midazolam, hydroxyzine and its metabolite cetirizine, ketamine, etomidate, laudanosine (atracurium metabolite), lidocaine. Additionally, two NPS were identified and then confirmed with certified reference materials (CRM): MDPHP in plasma and urine, and 25H-NBOH in urine. 25H-NBOH was not detected in plasma despite a limit of detection being 0.01 ng/mL. Unfortunately, there were not enough remaining samples after the screening analyzes, therefore the quantification could not be carried out. In order to estimate the concentration, a calibration curve was carried out with the two compounds under the same conditions as the screening analysis (same pretreatment, same internal standards at the same concentrations, as well as the same analytical conditions), and the data corresponding to the initial acquisition was then reprocessed. MDPHP concentration was 1 ng/mL in plasma and 48 ng/mL in urine, 25H-NBOH concentration was 0.4 ng/mL in urine. 25I-NBOH was specifically searched in both samples and was not detected. MDPHP is a synthetic cathinone of the pyrovalerone type (e.g. MDPV), it acts as a stimulant on the release of dopamine and norephedrine and simultaneously as reuptake inhibitor, causing a pronounced stimulatory effect on the central nervous system (Grapp M, et al., Drug Test Anal 2020;12:1320–35). 25H-NBOH is a psychedelic belonging to the NBOMe family, they are potent agonists of 5-HT2A receptor (Pottie et al., Biochem Pharmacol 2020;182:114251). The clinical manifestations observed here are similar to those described in cases of NBOMe poisoning, and are probably attributable to 25H-NBOH, they may have been potentiated by the presence of MDPHP (Kyriakou C, et al., Eur Rev Med Pharmacol Sci 2015;19:3270–81). To our knowledge, very few study have been dedicated to MDPHP poisoning, and this is the first describing 25H-NBOH poisoning." @default.
• W4291291546 created "2022-08-14" @default.
• W4291291546 creator A5045396101 @default.
• W4291291546 creator A5047041215 @default.
• W4291291546 creator A5072651738 @default.
• W4291291546 creator A5080040646 @default.
• W4291291546 creator A5090530947 @default.
• W4291291546 date "2022-09-01" @default.
• W4291291546 modified "2023-10-05" @default.
• W4291291546 title "Serotonin syndrome onset following 25H-NBOH and MDPHP consumption: A case report" @default.
• W4291291546 doi "https://doi.org/10.1016/j.toxac.2022.06.025" @default.
• W4291291546 hasPublicationYear "2022" @default.
• W4291291546 type Work @default.
• W4291291546 citedByCount "0" @default.
• W4291291546 crossrefType "journal-article" @default.
• W4291291546 hasAuthorship W4291291546A5045396101 @default.
• W4291291546 hasAuthorship W4291291546A5047041215 @default.
• W4291291546 hasAuthorship W4291291546A5072651738 @default.
• W4291291546 hasAuthorship W4291291546A5080040646 @default.
• W4291291546 hasAuthorship W4291291546A5090530947 @default.
• W4291291546 hasConcept C2779379848 @default.
• W4291291546 hasConcept C42219234 @default.
• W4291291546 hasConcept C71924100 @default.
• W4291291546 hasConceptScore W4291291546C2779379848 @default.
• W4291291546 hasConceptScore W4291291546C42219234 @default.
• W4291291546 hasConceptScore W4291291546C71924100 @default.
• W4291291546 hasIssue "3" @default.
• W4291291546 hasLocation W42912915461 @default.
• W4291291546 hasOpenAccess W4291291546 @default.
• W4291291546 hasPrimaryLocation W42912915461 @default.
• W4291291546 hasRelatedWork W1506200166 @default.
• W4291291546 hasRelatedWork W1995515455 @default.
• W4291291546 hasRelatedWork W2080531066 @default.
• W4291291546 hasRelatedWork W2748952813 @default.
• W4291291546 hasRelatedWork W2899084033 @default.
• W4291291546 hasRelatedWork W3031052312 @default.
• W4291291546 hasRelatedWork W3032375762 @default.
• W4291291546 hasRelatedWork W3108674512 @default.
• W4291291546 hasRelatedWork W4241555251 @default.
• W4291291546 hasRelatedWork W4386154539 @default.
• W4291291546 hasVolume "34" @default.
• W4291291546 isParatext "false" @default.
• W4291291546 isRetracted "false" @default.
• W4291291546 workType "article" @default.