Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291320121> ?p ?o ?g. }
- W4291320121 abstract "Abstract Transcription factors regulate gene expression by binding to regulatory DNA and recruiting regulatory protein complexes. The DNA-binding and protein-binding functions of transcription factors are traditionally described as independent functions performed by modular protein domains. Here, I argue that genome binding can be a 2-part process with both DNA-binding and protein-binding steps, enabling transcription factors to perform a 2-step search of the nucleus to find their appropriate binding sites in a eukaryotic genome. I support this hypothesis with new and old results in the literature, discuss how this hypothesis parsimoniously resolves outstanding problems, and present testable predictions." @default.
- W4291320121 created "2022-08-14" @default.
- W4291320121 creator A5087995416 @default.
- W4291320121 date "2022-08-08" @default.
- W4291320121 modified "2023-09-24" @default.
- W4291320121 title "Transcription factors perform a 2-step search of the nucleus" @default.
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- W4291320121 doi "https://doi.org/10.1093/genetics/iyac111" @default.
- W4291320121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35939561" @default.
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