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- W4291340400 abstract "The cell envelope of Gram-negative bacteria is composed of an inner membrane, outer membane, and an intervening periplasmic space. How the outer membrane lipids are trafficked and assembled there, and how the asymmetry of the outer membrane is maintained is an area of intense research. The Mla system has been implicated in the maintenance of lipid asymmetry in the outer membrane, and is generally thought to drive the removal of mislocalized phospholipids from the outer membrane and their retrograde transport to the inner membrane. At the heart of the Mla pathway is a structurally unique ABC transporter complex in the inner membrane, called MlaFEDB. Recently, an explosion of cryo-EM studies has begun to shed light on the structure and lipid translocation mechanism of MlaFEDB, with many parallels to other ABC transporter families, including human ABCA and ABCG, as well as bacterial lipopolysaccharide and O-antigen transporters. Here we synthesize information from all available structures, and propose a model for lipid trafficking across the cell envelope by MlaFEDB." @default.
- W4291340400 created "2022-08-15" @default.
- W4291340400 creator A5035906760 @default.
- W4291340400 creator A5055117782 @default.
- W4291340400 creator A5066717627 @default.
- W4291340400 date "2022-10-01" @default.
- W4291340400 modified "2023-10-16" @default.
- W4291340400 title "Structure and mechanism of the bacterial lipid ABC transporter, MlaFEDB" @default.
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- W4291340400 doi "https://doi.org/10.1016/j.sbi.2022.102429" @default.
- W4291340400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35981415" @default.
- W4291340400 hasPublicationYear "2022" @default.
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