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• W4291378291 abstract "Objective To investigate the effect of the 131 I-labeled high-affinity peptides Caerin 1.1 and Caerin 1.9 for the treatment of A549 human NSCLC cells. Methods ① 3-[4,5-Dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and plate clone formation assays were performed to confirm the in vitro anti-tumor activity of Caerin 1.1 and Caerin 1.9. ② Chloramine-T was used to label Caerin 1.1 and Caerin 1.9 with 131 I, and the Cell Counting Kit 8 assay was performed to analyze the inhibitory effect of unlabeled Caerin 1.1, unlabeled Caerin 1.9, 131 I-labeled Caerin 1.1, and 131 I-labeled Caerin 1.9 on the proliferation of NSCLC cells. An A549 NSCLC nude mouse model was established to investigate the in vivo anti-tumor activity of unlabeled Caerin 1.1, unlabeled Caerin 1.9, 131 I-labeled Caerin 1.1, and 131 I-labeled Caerin 1.9. Results ① Caerin 1.1 and Caerin 1.9 inhibited the proliferation of NSCLC cells in vitro in a concentration-dependent manner. The half-maximal inhibitory concentration was 16.26 µg/ml and 17.46 µg/ml, respectively, with no significant intergroup difference (P&gt;0.05). ② 131 I-labeled Caerin 1.1 and 131 I-labeled Caerin 1.9 were equally effective and were superior to their unlabeled versions in their ability to inhibit the proliferation and growth of NSCLC cells (P&gt;0.05). Conclusions 131 I-labeled Caerin 1.1 and 131 I-labeled Caerin 1.9 inhibit the proliferation and growth of NSCLC cells and may become potential treatments for NSCLC." @default.
• W4291378291 created "2022-08-15" @default.
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• W4291378291 date "2022-08-15" @default.
• W4291378291 modified "2023-10-18" @default.
• W4291378291 title "131I-Caerin 1.1 and 131I-Caerin 1.9 for the treatment of non-small-cell lung cancer" @default.
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• W4291378291 doi "https://doi.org/10.3389/fonc.2022.861206" @default.
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