Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291391860> ?p ?o ?g. }
- W4291391860 endingPage "3665" @default.
- W4291391860 startingPage "3648" @default.
- W4291391860 abstract "Breast cancer is the leading cause of cancer death among women worldwide. Multiple extrinsic and intrinsic factors are associated with this disease's development. Various research groups worldwide have reported the presence of human papillomavirus (HPV) DNA in samples of malignant breast tumors. Although its role in mammary carcinogenesis is not fully understood, it is known that the HPV genome, once inserted into host cells, has oncogenic capabilities. The present study aimed to detect the presence of HPV DNA in 116 breast tissue biopsies and classify them according to their histology. It was found that 50.9% of the breast biopsies analyzed were malignant neoplasms, of which 74.6% were histologically classified as infiltrating ductal carcinoma. In biopsies with non-malignant breast disease, fibroadenoma was the most common benign neoplasm (39.1%). Detection of HPV DNA was performed through nested PCR using the external primer MY09/11 and the internal primer GP5+/6+. A hybridization assay genotyped HPV. HPV DNA was identified in 20.3% (12/59) of malignant neoplasms and 35% non-malignant breast disease (16/46). It was also detected in 27.3% (3/11) of breast tissue biopsies without alteration. However, there are no statistically significant differences between these groups and the existence of HPV DNA (p = 0.2521). Its presence was more frequent in non-malignant alterations than in malignant neoplasias. The most frequent genotypes in the HPV-positive samples were low-risk (LR) HPV-42 followed by high-risk (HR) HPV-31." @default.
- W4291391860 created "2022-08-15" @default.
- W4291391860 creator A5000540554 @default.
- W4291391860 creator A5004268466 @default.
- W4291391860 creator A5011044886 @default.
- W4291391860 creator A5024879180 @default.
- W4291391860 creator A5027832988 @default.
- W4291391860 creator A5060230558 @default.
- W4291391860 creator A5060265948 @default.
- W4291391860 creator A5064376971 @default.
- W4291391860 creator A5080488967 @default.
- W4291391860 creator A5081666526 @default.
- W4291391860 creator A5085592068 @default.
- W4291391860 date "2022-08-13" @default.
- W4291391860 modified "2023-10-01" @default.
- W4291391860 title "Presence of Human Papillomavirus DNA in Malignant Neoplasia and Non-Malignant Breast Disease" @default.
- W4291391860 cites W14246907 @default.
- W4291391860 cites W1773212502 @default.
- W4291391860 cites W1821289578 @default.
- W4291391860 cites W1864408132 @default.
- W4291391860 cites W1873310047 @default.
- W4291391860 cites W1905380354 @default.
- W4291391860 cites W1966676297 @default.
- W4291391860 cites W1966803404 @default.
- W4291391860 cites W1967892382 @default.
- W4291391860 cites W1971733232 @default.
- W4291391860 cites W1985588702 @default.
- W4291391860 cites W1988398219 @default.
- W4291391860 cites W1991182452 @default.
- W4291391860 cites W1995975609 @default.
- W4291391860 cites W1996462950 @default.
- W4291391860 cites W2001003399 @default.
- W4291391860 cites W2006433536 @default.
- W4291391860 cites W2007008878 @default.
- W4291391860 cites W2015768562 @default.
- W4291391860 cites W2016183157 @default.
- W4291391860 cites W2018473690 @default.
- W4291391860 cites W2019907256 @default.
- W4291391860 cites W2021503402 @default.
- W4291391860 cites W2035449764 @default.
- W4291391860 cites W2035782078 @default.
- W4291391860 cites W2037324717 @default.
- W4291391860 cites W2043149497 @default.
- W4291391860 cites W2044748653 @default.
- W4291391860 cites W2050316994 @default.
- W4291391860 cites W2056217701 @default.
- W4291391860 cites W2066979922 @default.
- W4291391860 cites W2067950119 @default.
- W4291391860 cites W2079458026 @default.
- W4291391860 cites W2080171736 @default.
- W4291391860 cites W2085794881 @default.
- W4291391860 cites W2094760103 @default.
- W4291391860 cites W2105608547 @default.
- W4291391860 cites W2113014285 @default.
- W4291391860 cites W2126699154 @default.
- W4291391860 cites W2129811687 @default.
- W4291391860 cites W2135768293 @default.
- W4291391860 cites W2141272547 @default.
- W4291391860 cites W2146719605 @default.
- W4291391860 cites W2153709962 @default.
- W4291391860 cites W2159732020 @default.
- W4291391860 cites W2160590722 @default.
- W4291391860 cites W2166534628 @default.
- W4291391860 cites W2171354360 @default.
- W4291391860 cites W2172261799 @default.
- W4291391860 cites W2228859758 @default.
- W4291391860 cites W2233562967 @default.
- W4291391860 cites W2234933111 @default.
- W4291391860 cites W2236782700 @default.
- W4291391860 cites W2344964246 @default.
- W4291391860 cites W2404595962 @default.
- W4291391860 cites W2419247614 @default.
- W4291391860 cites W2509507929 @default.
- W4291391860 cites W2531094355 @default.
- W4291391860 cites W2592748155 @default.
- W4291391860 cites W2594053974 @default.
- W4291391860 cites W2604423996 @default.
- W4291391860 cites W2612688759 @default.
- W4291391860 cites W2735550539 @default.
- W4291391860 cites W2737129502 @default.
- W4291391860 cites W2778917084 @default.
- W4291391860 cites W2786138834 @default.
- W4291391860 cites W2793700020 @default.
- W4291391860 cites W2797127469 @default.
- W4291391860 cites W2803084739 @default.
- W4291391860 cites W2804393631 @default.
- W4291391860 cites W2806980384 @default.
- W4291391860 cites W2885386961 @default.
- W4291391860 cites W2897000863 @default.
- W4291391860 cites W2900173947 @default.
- W4291391860 cites W2911836051 @default.
- W4291391860 cites W2932817819 @default.
- W4291391860 cites W2946134908 @default.
- W4291391860 cites W2965371519 @default.
- W4291391860 cites W2969885351 @default.
- W4291391860 cites W3034399965 @default.
- W4291391860 cites W3091161507 @default.
- W4291391860 cites W3093700985 @default.