Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291465401> ?p ?o ?g. }
- W4291465401 endingPage "9088" @default.
- W4291465401 startingPage "9088" @default.
- W4291465401 abstract "The expression of Hemoglobin (Hb) is not restricted to erythrocytes but is also present in neurons. Hb is selectively enriched in vulnerable mesencephalic dopaminergic neurons of Parkinson's disease (PD) instead of resistant neurons. Controversial results of neuronal Hb levels have been reported in postmortem brains of PD patients: although neuronal Hb levels may decline in PD patients, elderly men with higher Hb levels have an increased risk of developing PD. α-synuclein, a key protein involved in PD pathology, interacts directly with Hb protein and forms complexes in erythrocytes and brains of monkeys and humans. These complexes increase in erythrocytes and striatal cytoplasm, while they decrease in striatal mitochondria with aging. Besides, the colocalization of serine 129-phosphorylated (Pser129) α-synuclein and Hb β chains have been found in the brains of PD patients. Several underlying molecular mechanisms involving mitochondrial homeostasis, α-synuclein accumulation, iron metabolism, and hormone-regulated signaling pathways have been investigated to assess the relationship between neuronal Hb and PD development. The formation of fibrils with neuronal Hb in various neurodegenerative diseases may indicate a common fibrillization pathway and a widespread target that could be applied in neurodegeneration therapy." @default.
- W4291465401 created "2022-08-15" @default.
- W4291465401 creator A5005215105 @default.
- W4291465401 creator A5016170913 @default.
- W4291465401 creator A5050138757 @default.
- W4291465401 creator A5087744744 @default.
- W4291465401 date "2022-08-13" @default.
- W4291465401 modified "2023-09-26" @default.
- W4291465401 title "Physiological and Pathological Functions of Neuronal Hemoglobin: A Key Underappreciated Protein in Parkinson’s Disease" @default.
- W4291465401 cites W1485428386 @default.
- W4291465401 cites W1530025145 @default.
- W4291465401 cites W154036014 @default.
- W4291465401 cites W1571772337 @default.
- W4291465401 cites W1576441802 @default.
- W4291465401 cites W1594404253 @default.
- W4291465401 cites W1677755327 @default.
- W4291465401 cites W1968251608 @default.
- W4291465401 cites W1971971713 @default.
- W4291465401 cites W1974709573 @default.
- W4291465401 cites W1976113375 @default.
- W4291465401 cites W1976775990 @default.
- W4291465401 cites W1978972221 @default.
- W4291465401 cites W1982686390 @default.
- W4291465401 cites W1985458075 @default.
- W4291465401 cites W1994874328 @default.
- W4291465401 cites W1995191747 @default.
- W4291465401 cites W1996897470 @default.
- W4291465401 cites W1997183854 @default.
- W4291465401 cites W2002166614 @default.
- W4291465401 cites W2003115630 @default.
- W4291465401 cites W2003406245 @default.
- W4291465401 cites W2007351878 @default.
- W4291465401 cites W2015846334 @default.
- W4291465401 cites W2016905315 @default.
- W4291465401 cites W2022541264 @default.
- W4291465401 cites W2022804099 @default.
- W4291465401 cites W2025048194 @default.
- W4291465401 cites W2027894212 @default.
- W4291465401 cites W2029255665 @default.
- W4291465401 cites W2029409908 @default.
- W4291465401 cites W2029470567 @default.
- W4291465401 cites W2032288122 @default.
- W4291465401 cites W2033107351 @default.
- W4291465401 cites W2039403847 @default.
- W4291465401 cites W2042858283 @default.
- W4291465401 cites W2044780622 @default.
- W4291465401 cites W2054867614 @default.
- W4291465401 cites W2057095204 @default.
- W4291465401 cites W2059175990 @default.
- W4291465401 cites W2060044823 @default.
- W4291465401 cites W2060781047 @default.
- W4291465401 cites W2062035980 @default.
- W4291465401 cites W2064887226 @default.
- W4291465401 cites W2066960428 @default.
- W4291465401 cites W2069368439 @default.
- W4291465401 cites W2070989544 @default.
- W4291465401 cites W2072999198 @default.
- W4291465401 cites W2075161068 @default.
- W4291465401 cites W2076425557 @default.
- W4291465401 cites W2077409344 @default.
- W4291465401 cites W2078034476 @default.
- W4291465401 cites W2081020021 @default.
- W4291465401 cites W2083643006 @default.
- W4291465401 cites W2087291116 @default.
- W4291465401 cites W2090305802 @default.
- W4291465401 cites W2093153970 @default.
- W4291465401 cites W2095239427 @default.
- W4291465401 cites W2097238632 @default.
- W4291465401 cites W2103315169 @default.
- W4291465401 cites W2109242929 @default.
- W4291465401 cites W2110647520 @default.
- W4291465401 cites W2112867510 @default.
- W4291465401 cites W2116081441 @default.
- W4291465401 cites W2119442234 @default.
- W4291465401 cites W2121127591 @default.
- W4291465401 cites W2124940469 @default.
- W4291465401 cites W2127675927 @default.
- W4291465401 cites W2130688535 @default.
- W4291465401 cites W2136958231 @default.
- W4291465401 cites W2145308945 @default.
- W4291465401 cites W2152165298 @default.
- W4291465401 cites W2153647147 @default.
- W4291465401 cites W2157819664 @default.
- W4291465401 cites W2158662449 @default.
- W4291465401 cites W2238943778 @default.
- W4291465401 cites W2263759154 @default.
- W4291465401 cites W2268858065 @default.
- W4291465401 cites W2390640775 @default.
- W4291465401 cites W2500346938 @default.
- W4291465401 cites W2522661041 @default.
- W4291465401 cites W2533876757 @default.
- W4291465401 cites W2537555798 @default.
- W4291465401 cites W2555006703 @default.
- W4291465401 cites W2556274105 @default.
- W4291465401 cites W2564013038 @default.
- W4291465401 cites W2568513215 @default.
- W4291465401 cites W2586062838 @default.
- W4291465401 cites W2587628279 @default.