Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291624759> ?p ?o ?g. }
- W4291624759 abstract "Host anti-viral factors are essential for controlling SARS-CoV-2 infection but remain largely unknown due to the biases of previous large-scale studies toward pro-viral host factors. To fill in this knowledge gap, we performed a genome-wide CRISPR dropout screen and integrated analyses of the multi-omics data of the CRISPR screen, genome-wide association studies, single-cell RNA-seq, and host-virus proteins or protein/RNA interactome. This study has uncovered many host factors that were missed by previous studies, including the components of V-ATPases, ESCRT, and N-glycosylation pathways that modulated viral entry and/or replication. The cohesin complex was also identified as a novel anti-viral pathway, suggesting an important role of three-dimensional chromatin organization in mediating host-viral interaction. Furthermore, we discovered an anti-viral regulator KLF5, a transcriptional factor involved in sphingolipid metabolism, which was up-regulated and harbored genetic variations linked to the COVID-19 patients with severe symptoms. Our results provide a resource for understanding the host anti-viral network during SARS-CoV-2 infection and may help develop new countermeasure strategies." @default.
- W4291624759 created "2022-08-15" @default.
- W4291624759 creator A5007160108 @default.
- W4291624759 creator A5012952780 @default.
- W4291624759 creator A5024000128 @default.
- W4291624759 creator A5043889062 @default.
- W4291624759 creator A5055060386 @default.
- W4291624759 creator A5056869329 @default.
- W4291624759 creator A5057764651 @default.
- W4291624759 creator A5060171947 @default.
- W4291624759 creator A5067080039 @default.
- W4291624759 creator A5071360122 @default.
- W4291624759 creator A5088133308 @default.
- W4291624759 date "2022-08-15" @default.
- W4291624759 modified "2023-10-18" @default.
- W4291624759 title "Integrated multi-omics analyses identify key anti-viral host factors and pathways controlling SARS-CoV-2 infection" @default.
- W4291624759 cites W1498924706 @default.
- W4291624759 cites W1981079665 @default.
- W4291624759 cites W2013729196 @default.
- W4291624759 cites W2040518239 @default.
- W4291624759 cites W2055230903 @default.
- W4291624759 cites W2074130602 @default.
- W4291624759 cites W2094398576 @default.
- W4291624759 cites W2100122648 @default.
- W4291624759 cites W2141075240 @default.
- W4291624759 cites W2160004933 @default.
- W4291624759 cites W2795719567 @default.
- W4291624759 cites W2800525982 @default.
- W4291624759 cites W2886806646 @default.
- W4291624759 cites W2898577086 @default.
- W4291624759 cites W3004318991 @default.
- W4291624759 cites W3015751519 @default.
- W4291624759 cites W3022285953 @default.
- W4291624759 cites W3092135414 @default.
- W4291624759 cites W3093053585 @default.
- W4291624759 cites W3093120161 @default.
- W4291624759 cites W3093213262 @default.
- W4291624759 cites W3093900830 @default.
- W4291624759 cites W3094597057 @default.
- W4291624759 cites W3110976643 @default.
- W4291624759 cites W3111836713 @default.
- W4291624759 cites W3113360200 @default.
- W4291624759 cites W3114675079 @default.
- W4291624759 cites W3119160476 @default.
- W4291624759 cites W3124794958 @default.
- W4291624759 cites W3125073942 @default.
- W4291624759 cites W3128335178 @default.
- W4291624759 cites W3131593383 @default.
- W4291624759 cites W3133293868 @default.
- W4291624759 cites W3134627077 @default.
- W4291624759 cites W3134844657 @default.
- W4291624759 cites W3140158048 @default.
- W4291624759 cites W3159377351 @default.
- W4291624759 cites W3159493973 @default.
- W4291624759 cites W3162816627 @default.
- W4291624759 cites W3165280603 @default.
- W4291624759 cites W3173987271 @default.
- W4291624759 cites W3178150389 @default.
- W4291624759 cites W3178283518 @default.
- W4291624759 cites W3178327581 @default.
- W4291624759 cites W3179611001 @default.
- W4291624759 cites W3182807823 @default.
- W4291624759 cites W3186784272 @default.
- W4291624759 cites W3193422884 @default.
- W4291624759 cites W3212068808 @default.
- W4291624759 cites W4200177230 @default.
- W4291624759 cites W4226036062 @default.
- W4291624759 cites W4226321964 @default.
- W4291624759 cites W4281491305 @default.
- W4291624759 cites W4282939689 @default.
- W4291624759 cites W4287510130 @default.
- W4291624759 cites W4287510152 @default.
- W4291624759 doi "https://doi.org/10.21203/rs.3.rs-1910932/v1" @default.
- W4291624759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36032971" @default.
- W4291624759 hasPublicationYear "2022" @default.
- W4291624759 type Work @default.
- W4291624759 citedByCount "3" @default.
- W4291624759 countsByYear W42916247592022 @default.
- W4291624759 countsByYear W42916247592023 @default.
- W4291624759 crossrefType "posted-content" @default.
- W4291624759 hasAuthorship W4291624759A5007160108 @default.
- W4291624759 hasAuthorship W4291624759A5012952780 @default.
- W4291624759 hasAuthorship W4291624759A5024000128 @default.
- W4291624759 hasAuthorship W4291624759A5043889062 @default.
- W4291624759 hasAuthorship W4291624759A5055060386 @default.
- W4291624759 hasAuthorship W4291624759A5056869329 @default.
- W4291624759 hasAuthorship W4291624759A5057764651 @default.
- W4291624759 hasAuthorship W4291624759A5060171947 @default.
- W4291624759 hasAuthorship W4291624759A5067080039 @default.
- W4291624759 hasAuthorship W4291624759A5071360122 @default.
- W4291624759 hasAuthorship W4291624759A5088133308 @default.
- W4291624759 hasBestOaLocation W42916247591 @default.
- W4291624759 hasConcept C104317684 @default.
- W4291624759 hasConcept C126831891 @default.
- W4291624759 hasConcept C140704245 @default.
- W4291624759 hasConcept C145059251 @default.
- W4291624759 hasConcept C159047783 @default.
- W4291624759 hasConcept C166703698 @default.
- W4291624759 hasConcept C2522874641 @default.
- W4291624759 hasConcept C54355233 @default.