Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291653886> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4291653886 abstract "Cell fate decisions in multicellular organisms are precisely coordinated, leading to highly reproducible macroscopic outcomes of developmental processes. The origins of this reproducibility can be found at the molecular level during the earliest stages of development when spatial patterns of morphogen (form-generating) molecules emerge reproducibly. However, the initial conditions for these early stages are determined by the female during oogenesis, and it is unknown whether reproducibility is passed on to the zygote or whether it is reacquired by the zygote. Here we examine the earliest reproducible pattern in the Drosophila embryo, the Bicoid protein gradient. Using a unique combination of absolute molecule counting techniques, we show that it is generated from a highly controlled source of mRNA molecules that is reproducible from embryo to embryo to within ~8%. This occurs in a perfectly linear feed-forward process: changes in the female's gene dosage lead to proportional changes in the mRNA and protein counts in the embryo. In this setup, noise is kept low in the transition from one molecular species to another, allowing the female to precisely deposit the same absolute number of mRNA molecules in each embryo and therefore confer reproducibility to the Bicoid pattern. Our results indicate that the reproducibility of the morphological structures that emerge in the embryo originates during oogenesis when all initial patterning signals are controlled with precision similar to what we observe for the Bicoid pattern." @default.
- W4291653886 created "2022-08-15" @default.
- W4291653886 creator A5008050048 @default.
- W4291653886 creator A5060470951 @default.
- W4291653886 creator A5072358509 @default.
- W4291653886 date "2013-09-24" @default.
- W4291653886 modified "2023-09-28" @default.
- W4291653886 title "Maternal origins of developmental reproducibility" @default.
- W4291653886 doi "https://doi.org/10.48550/arxiv.1309.6271" @default.
- W4291653886 hasPublicationYear "2013" @default.
- W4291653886 type Work @default.
- W4291653886 citedByCount "0" @default.
- W4291653886 crossrefType "posted-content" @default.
- W4291653886 hasAuthorship W4291653886A5008050048 @default.
- W4291653886 hasAuthorship W4291653886A5060470951 @default.
- W4291653886 hasAuthorship W4291653886A5072358509 @default.
- W4291653886 hasBestOaLocation W42916538861 @default.
- W4291653886 hasConcept C104317684 @default.
- W4291653886 hasConcept C167290458 @default.
- W4291653886 hasConcept C183074962 @default.
- W4291653886 hasConcept C185592680 @default.
- W4291653886 hasConcept C196843134 @default.
- W4291653886 hasConcept C2778386714 @default.
- W4291653886 hasConcept C28748434 @default.
- W4291653886 hasConcept C43617362 @default.
- W4291653886 hasConcept C54355233 @default.
- W4291653886 hasConcept C74318829 @default.
- W4291653886 hasConcept C78458016 @default.
- W4291653886 hasConcept C86803240 @default.
- W4291653886 hasConcept C87073359 @default.
- W4291653886 hasConcept C95444343 @default.
- W4291653886 hasConcept C9893847 @default.
- W4291653886 hasConceptScore W4291653886C104317684 @default.
- W4291653886 hasConceptScore W4291653886C167290458 @default.
- W4291653886 hasConceptScore W4291653886C183074962 @default.
- W4291653886 hasConceptScore W4291653886C185592680 @default.
- W4291653886 hasConceptScore W4291653886C196843134 @default.
- W4291653886 hasConceptScore W4291653886C2778386714 @default.
- W4291653886 hasConceptScore W4291653886C28748434 @default.
- W4291653886 hasConceptScore W4291653886C43617362 @default.
- W4291653886 hasConceptScore W4291653886C54355233 @default.
- W4291653886 hasConceptScore W4291653886C74318829 @default.
- W4291653886 hasConceptScore W4291653886C78458016 @default.
- W4291653886 hasConceptScore W4291653886C86803240 @default.
- W4291653886 hasConceptScore W4291653886C87073359 @default.
- W4291653886 hasConceptScore W4291653886C95444343 @default.
- W4291653886 hasConceptScore W4291653886C9893847 @default.
- W4291653886 hasLocation W42916538861 @default.
- W4291653886 hasOpenAccess W4291653886 @default.
- W4291653886 hasPrimaryLocation W42916538861 @default.
- W4291653886 hasRelatedWork W1594660205 @default.
- W4291653886 hasRelatedWork W2014366092 @default.
- W4291653886 hasRelatedWork W2030514921 @default.
- W4291653886 hasRelatedWork W2073881036 @default.
- W4291653886 hasRelatedWork W2075359789 @default.
- W4291653886 hasRelatedWork W2077592586 @default.
- W4291653886 hasRelatedWork W2087139571 @default.
- W4291653886 hasRelatedWork W2113555308 @default.
- W4291653886 hasRelatedWork W2949144412 @default.
- W4291653886 hasRelatedWork W3195056360 @default.
- W4291653886 isParatext "false" @default.
- W4291653886 isRetracted "false" @default.
- W4291653886 workType "article" @default.