Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291674810> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4291674810 endingPage "103168" @default.
- W4291674810 startingPage "103168" @default.
- W4291674810 abstract "Systemic sclerosis (SSc) is a systemic autoimmune disease with heterogeneous clinical presentation and prognosis. JAK inhibitors reduced cutaneous and pulmonary fibrosis in mice models of SSc. Clinical data regarding the efficacy and safety of JAK inhibitors in SSc patients are scarce.We performed a systematic literature review of patients with SSc defined by the 2013 ACR/EULAR criteria and treated with JAK inhibitors, searching in Medline, Cochrane library and Embase databases.Fifty-nine patients (mean age 47 ± 15 years) were included. Median treatment duration was 12 [6-12] months. JAK inhibitors (tofacitinib in 47 patients and baricitinib in 12 patients) were prescribed as first line therapy in 35 patients (59%). A significant cutaneous response (decrease in the mRSS - modified Rodnan skin score - of >5 points and ≥ 25% from baseline) was reported in 52 patients (88%). Among patients with interstitial lung disease (ILD) (n = 31), 28/29 patients had no ILD progression during follow-up time (missing data in 2 patients). Only 2 patients had a disease progression during treatment (including one patient with progressive skin fibrosis). Cutaneous response was more frequently observed in treatment naïve SSc patients. Decrease of the mRSS after treatment initiation was more significant in treatment naïve SSc patients. Eighteen non-serious side-effects were noted in 12 patients (20%), without treatment interruption: 6 infections, 6 gastrointestinal disorders, 4 hepatitis and 3 dyslipidemias.JAK inhibitors could represent a safe and effective treatment option for skin fibrosis and ILD in systemic sclerosis." @default.
- W4291674810 created "2022-08-15" @default.
- W4291674810 creator A5014700089 @default.
- W4291674810 creator A5048808791 @default.
- W4291674810 creator A5076019275 @default.
- W4291674810 creator A5087718720 @default.
- W4291674810 date "2022-10-01" @default.
- W4291674810 modified "2023-10-16" @default.
- W4291674810 title "JAK inhibitors and systemic sclerosis: A systematic review of the literature" @default.
- W4291674810 cites W1505701939 @default.
- W4291674810 cites W1979881623 @default.
- W4291674810 cites W2014330392 @default.
- W4291674810 cites W2014823731 @default.
- W4291674810 cites W2131014787 @default.
- W4291674810 cites W2498506084 @default.
- W4291674810 cites W2588044396 @default.
- W4291674810 cites W2626892937 @default.
- W4291674810 cites W2779661793 @default.
- W4291674810 cites W2793041868 @default.
- W4291674810 cites W2890199186 @default.
- W4291674810 cites W2939397596 @default.
- W4291674810 cites W2945521814 @default.
- W4291674810 cites W2947998848 @default.
- W4291674810 cites W3008900858 @default.
- W4291674810 cites W3035862891 @default.
- W4291674810 cites W3093894701 @default.
- W4291674810 cites W3105187542 @default.
- W4291674810 cites W3115951749 @default.
- W4291674810 cites W3119425316 @default.
- W4291674810 cites W3126499013 @default.
- W4291674810 cites W3179501460 @default.
- W4291674810 cites W3184447129 @default.
- W4291674810 cites W867807832 @default.
- W4291674810 doi "https://doi.org/10.1016/j.autrev.2022.103168" @default.
- W4291674810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35944611" @default.
- W4291674810 hasPublicationYear "2022" @default.
- W4291674810 type Work @default.
- W4291674810 citedByCount "17" @default.
- W4291674810 countsByYear W42916748102022 @default.
- W4291674810 countsByYear W42916748102023 @default.
- W4291674810 crossrefType "journal-article" @default.
- W4291674810 hasAuthorship W4291674810A5014700089 @default.
- W4291674810 hasAuthorship W4291674810A5048808791 @default.
- W4291674810 hasAuthorship W4291674810A5076019275 @default.
- W4291674810 hasAuthorship W4291674810A5087718720 @default.
- W4291674810 hasBestOaLocation W42916748101 @default.
- W4291674810 hasConcept C126322002 @default.
- W4291674810 hasConcept C142724271 @default.
- W4291674810 hasConcept C16005928 @default.
- W4291674810 hasConcept C180032290 @default.
- W4291674810 hasConcept C2777543607 @default.
- W4291674810 hasConcept C2777575956 @default.
- W4291674810 hasConcept C2777714996 @default.
- W4291674810 hasConcept C2778822529 @default.
- W4291674810 hasConcept C2778886723 @default.
- W4291674810 hasConcept C2779134260 @default.
- W4291674810 hasConcept C2779967694 @default.
- W4291674810 hasConcept C71924100 @default.
- W4291674810 hasConcept C90924648 @default.
- W4291674810 hasConceptScore W4291674810C126322002 @default.
- W4291674810 hasConceptScore W4291674810C142724271 @default.
- W4291674810 hasConceptScore W4291674810C16005928 @default.
- W4291674810 hasConceptScore W4291674810C180032290 @default.
- W4291674810 hasConceptScore W4291674810C2777543607 @default.
- W4291674810 hasConceptScore W4291674810C2777575956 @default.
- W4291674810 hasConceptScore W4291674810C2777714996 @default.
- W4291674810 hasConceptScore W4291674810C2778822529 @default.
- W4291674810 hasConceptScore W4291674810C2778886723 @default.
- W4291674810 hasConceptScore W4291674810C2779134260 @default.
- W4291674810 hasConceptScore W4291674810C2779967694 @default.
- W4291674810 hasConceptScore W4291674810C71924100 @default.
- W4291674810 hasConceptScore W4291674810C90924648 @default.
- W4291674810 hasIssue "10" @default.
- W4291674810 hasLocation W42916748101 @default.
- W4291674810 hasLocation W42916748102 @default.
- W4291674810 hasOpenAccess W4291674810 @default.
- W4291674810 hasPrimaryLocation W42916748101 @default.
- W4291674810 hasRelatedWork W2149216352 @default.
- W4291674810 hasRelatedWork W2947482594 @default.
- W4291674810 hasRelatedWork W2962668272 @default.
- W4291674810 hasRelatedWork W2990607611 @default.
- W4291674810 hasRelatedWork W4223507797 @default.
- W4291674810 hasRelatedWork W4234833016 @default.
- W4291674810 hasRelatedWork W4286001097 @default.
- W4291674810 hasRelatedWork W4291674810 @default.
- W4291674810 hasRelatedWork W4293153395 @default.
- W4291674810 hasRelatedWork W4317885031 @default.
- W4291674810 hasVolume "21" @default.
- W4291674810 isParatext "false" @default.
- W4291674810 isRetracted "false" @default.
- W4291674810 workType "article" @default.