FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291710155> ?p ?o ?g. }

• W4291710155 abstract "Abstract Lipotoxicity induced by the overload of lipid in the liver, especially excess free cholesterol (FC), has been recognized as one of driving factors in the transition from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH). MicroRNA (miR)-379-5p has been reported to play regulatory roles in hepatic triglyceride homeostasis, but the relationship of miR-379-5p and hepatic cholesterol homeostasis has never been touched. In the current study, we found that hepatic miR-379-5p levels were decreased obviously in NAFLD patients and model mice compared with their controls. Moreover, miR-379-5p was discovered to be able to inhibit intracellular FC accumulation and alleviate mitochondrial damage induced by palmitic acid (PA) in vitro. Furthermore, overexpression of miR-379-5p in HFHC-fed db/db mice could reduce the level of hepatic total cholesterol (TC) and FC, and ameliorate hepatic injury reflected by the lower serum alanine aminotransferase (ALT) and aspartate transaminase (AST). Subsequently, by combining spectrometry (MS) and luciferase assay, we identified miR-379-5p suppressed STAT1 through transcriptional and translational regulation. Finally, we confirmed that STAT1 was a transcriptional factor of HMGCS1. In conclusion, miR-379-5p inhibits STAT1 expression and regulates cholesterol metabolism through the STAT1/HMGCS1 axis, suggesting miR-379-5p might be applied to improve lipotoxicity in the future." @default.
• W4291710155 created "2022-08-16" @default.
• W4291710155 creator A5040308047 @default.
• W4291710155 creator A5046742733 @default.
• W4291710155 creator A5048379858 @default.
• W4291710155 creator A5059000495 @default.
• W4291710155 creator A5060650400 @default.
• W4291710155 creator A5066757970 @default.
• W4291710155 creator A5085802282 @default.
• W4291710155 creator A5086350933 @default.
• W4291710155 creator A5087273879 @default.
• W4291710155 date "2022-08-10" @default.
• W4291710155 modified "2023-10-16" @default.
• W4291710155 title "MicroRNA-379-5p regulates free cholesterol accumulation and relieves diet induced-liver damage in db/db mice via STAT1/HMGCS1 axis" @default.
• W4291710155 cites W1598102702 @default.
• W4291710155 cites W1606178710 @default.
• W4291710155 cites W1968393209 @default.
• W4291710155 cites W2003512116 @default.
• W4291710155 cites W2068294387 @default.
• W4291710155 cites W2070053386 @default.
• W4291710155 cites W2182670456 @default.
• W4291710155 cites W2205982384 @default.
• W4291710155 cites W2288753073 @default.
• W4291710155 cites W2322792294 @default.
• W4291710155 cites W2361537312 @default.
• W4291710155 cites W2398660216 @default.
• W4291710155 cites W2619337392 @default.
• W4291710155 cites W2743471555 @default.
• W4291710155 cites W2770903823 @default.
• W4291710155 cites W2894504469 @default.
• W4291710155 cites W2897547577 @default.
• W4291710155 cites W2898404101 @default.
• W4291710155 cites W2899058989 @default.
• W4291710155 cites W2944735878 @default.
• W4291710155 cites W2953493870 @default.
• W4291710155 cites W2971999284 @default.
• W4291710155 cites W2976966984 @default.
• W4291710155 cites W2984472229 @default.
• W4291710155 cites W2989832464 @default.
• W4291710155 cites W2992802637 @default.
• W4291710155 cites W2996801544 @default.
• W4291710155 cites W3007703165 @default.
• W4291710155 cites W3022184332 @default.
• W4291710155 cites W3033722748 @default.
• W4291710155 cites W3049633611 @default.
• W4291710155 cites W3080500495 @default.
• W4291710155 cites W3088654978 @default.
• W4291710155 cites W3097712030 @default.
• W4291710155 cites W3099318048 @default.
• W4291710155 cites W3117083078 @default.
• W4291710155 cites W3119719581 @default.
• W4291710155 cites W3126401005 @default.
• W4291710155 cites W3138104919 @default.
• W4291710155 cites W3148416087 @default.
• W4291710155 cites W3160757640 @default.
• W4291710155 cites W3198350086 @default.
• W4291710155 cites W3199843021 @default.
• W4291710155 cites W3202301781 @default.
• W4291710155 cites W3209157631 @default.
• W4291710155 cites W4220672026 @default.
• W4291710155 doi "https://doi.org/10.1186/s43556-022-00089-w" @default.
• W4291710155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35945406" @default.
• W4291710155 hasPublicationYear "2022" @default.
• W4291710155 type Work @default.
• W4291710155 citedByCount "3" @default.
• W4291710155 countsByYear W42917101552023 @default.
• W4291710155 crossrefType "journal-article" @default.
• W4291710155 hasAuthorship W4291710155A5040308047 @default.
• W4291710155 hasAuthorship W4291710155A5046742733 @default.
• W4291710155 hasAuthorship W4291710155A5048379858 @default.
• W4291710155 hasAuthorship W4291710155A5059000495 @default.
• W4291710155 hasAuthorship W4291710155A5060650400 @default.
• W4291710155 hasAuthorship W4291710155A5066757970 @default.
• W4291710155 hasAuthorship W4291710155A5085802282 @default.
• W4291710155 hasAuthorship W4291710155A5086350933 @default.
• W4291710155 hasAuthorship W4291710155A5087273879 @default.
• W4291710155 hasBestOaLocation W42917101551 @default.
• W4291710155 hasConcept C104317684 @default.
• W4291710155 hasConcept C126322002 @default.
• W4291710155 hasConcept C127561419 @default.
• W4291710155 hasConcept C134018914 @default.
• W4291710155 hasConcept C160160445 @default.
• W4291710155 hasConcept C181199279 @default.
• W4291710155 hasConcept C185592680 @default.
• W4291710155 hasConcept C2777391703 @default.
• W4291710155 hasConcept C2778163477 @default.
• W4291710155 hasConcept C2778606649 @default.
• W4291710155 hasConcept C2778772119 @default.
• W4291710155 hasConcept C2778913445 @default.
• W4291710155 hasConcept C2779134260 @default.
• W4291710155 hasConcept C2779306644 @default.
• W4291710155 hasConcept C2779478299 @default.
• W4291710155 hasConcept C2779679107 @default.
• W4291710155 hasConcept C44353895 @default.
• W4291710155 hasConcept C4733338 @default.
• W4291710155 hasConcept C55493867 @default.
• W4291710155 hasConcept C63645605 @default.
• W4291710155 hasConcept C71924100 @default.
• W4291710155 hasConcept C86803240 @default.
• W4291710155 hasConceptScore W4291710155C104317684 @default.

• next