Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291711122> ?p ?o ?g. }
- W4291711122 endingPage "106096" @default.
- W4291711122 startingPage "106096" @default.
- W4291711122 abstract "Acute ischemic stroke is an important cause of death and long-term disability worldwide. In this work, we have synthesized a series of derivatives with 3,5‑diaryl substituent triazole scaffolds. The derivatives showed favorable protective effective in SNP-induced oxidative stress model, of which compound 5 was the most active. In vivo experiments showed that compound 5 could ameliorate neurological deficits, attenuate infarction sizes, reduce malonaldehyde (MDA) level and increase superoxide dismutase (SOD) level in middle cerebral artery occlusion (MCAO) rats. Preliminary safety evaluation showed that compound 5 exhibited low acute toxicity in BALB/c mice (LD50 greater than 1000 mg/kg). Further investigation indicated that compound 5 was able to scavenge ROS, restore mitochondrial membrane potential and protect PC12 cells from SNP-induced apoptosis. Moreover, compound 5 could initiate transcription of antioxidant response element (ARE) and induced expressions of antioxidative enzymes. Collectively, compound 5 might have the potency of treating acute ischemic stroke." @default.
- W4291711122 created "2022-08-16" @default.
- W4291711122 creator A5012178107 @default.
- W4291711122 creator A5012347044 @default.
- W4291711122 creator A5023310377 @default.
- W4291711122 creator A5043845587 @default.
- W4291711122 creator A5074406685 @default.
- W4291711122 creator A5082392206 @default.
- W4291711122 creator A5084444802 @default.
- W4291711122 creator A5091680687 @default.
- W4291711122 date "2022-11-01" @default.
- W4291711122 modified "2023-09-30" @default.
- W4291711122 title "Discovery of 1,2,4-triazole derivatives as novel neuroprotectants against cerebral ischemic injury by activating antioxidant response element" @default.
- W4291711122 cites W1525545408 @default.
- W4291711122 cites W2002805952 @default.
- W4291711122 cites W2009053094 @default.
- W4291711122 cites W2014034103 @default.
- W4291711122 cites W2044394663 @default.
- W4291711122 cites W2064188993 @default.
- W4291711122 cites W2093507774 @default.
- W4291711122 cites W2198773258 @default.
- W4291711122 cites W2404561274 @default.
- W4291711122 cites W2593436234 @default.
- W4291711122 cites W2618292058 @default.
- W4291711122 cites W2765609138 @default.
- W4291711122 cites W2792146494 @default.
- W4291711122 cites W2920989721 @default.
- W4291711122 cites W2921282526 @default.
- W4291711122 cites W2970118292 @default.
- W4291711122 cites W3004844045 @default.
- W4291711122 cites W3007596355 @default.
- W4291711122 cites W3011681752 @default.
- W4291711122 cites W3014834263 @default.
- W4291711122 cites W3084189106 @default.
- W4291711122 cites W3087226138 @default.
- W4291711122 cites W3096992445 @default.
- W4291711122 cites W3097793708 @default.
- W4291711122 cites W3118510185 @default.
- W4291711122 cites W3158584612 @default.
- W4291711122 cites W3160117384 @default.
- W4291711122 cites W3177922192 @default.
- W4291711122 cites W3209518115 @default.
- W4291711122 cites W4212880388 @default.
- W4291711122 cites W4212904635 @default.
- W4291711122 cites W4220793920 @default.
- W4291711122 cites W4220875331 @default.
- W4291711122 doi "https://doi.org/10.1016/j.bioorg.2022.106096" @default.
- W4291711122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35985158" @default.
- W4291711122 hasPublicationYear "2022" @default.
- W4291711122 type Work @default.
- W4291711122 citedByCount "7" @default.
- W4291711122 countsByYear W42917111222023 @default.
- W4291711122 crossrefType "journal-article" @default.
- W4291711122 hasAuthorship W4291711122A5012178107 @default.
- W4291711122 hasAuthorship W4291711122A5012347044 @default.
- W4291711122 hasAuthorship W4291711122A5023310377 @default.
- W4291711122 hasAuthorship W4291711122A5043845587 @default.
- W4291711122 hasAuthorship W4291711122A5074406685 @default.
- W4291711122 hasAuthorship W4291711122A5082392206 @default.
- W4291711122 hasAuthorship W4291711122A5084444802 @default.
- W4291711122 hasAuthorship W4291711122A5091680687 @default.
- W4291711122 hasConcept C150903083 @default.
- W4291711122 hasConcept C185592680 @default.
- W4291711122 hasConcept C207001950 @default.
- W4291711122 hasConcept C25498285 @default.
- W4291711122 hasConcept C2775838275 @default.
- W4291711122 hasConcept C2776151105 @default.
- W4291711122 hasConcept C2778004101 @default.
- W4291711122 hasConcept C48349386 @default.
- W4291711122 hasConcept C55493867 @default.
- W4291711122 hasConcept C71924100 @default.
- W4291711122 hasConcept C86803240 @default.
- W4291711122 hasConcept C98274493 @default.
- W4291711122 hasConceptScore W4291711122C150903083 @default.
- W4291711122 hasConceptScore W4291711122C185592680 @default.
- W4291711122 hasConceptScore W4291711122C207001950 @default.
- W4291711122 hasConceptScore W4291711122C25498285 @default.
- W4291711122 hasConceptScore W4291711122C2775838275 @default.
- W4291711122 hasConceptScore W4291711122C2776151105 @default.
- W4291711122 hasConceptScore W4291711122C2778004101 @default.
- W4291711122 hasConceptScore W4291711122C48349386 @default.
- W4291711122 hasConceptScore W4291711122C55493867 @default.
- W4291711122 hasConceptScore W4291711122C71924100 @default.
- W4291711122 hasConceptScore W4291711122C86803240 @default.
- W4291711122 hasConceptScore W4291711122C98274493 @default.
- W4291711122 hasLocation W42917111221 @default.
- W4291711122 hasLocation W42917111222 @default.
- W4291711122 hasOpenAccess W4291711122 @default.
- W4291711122 hasPrimaryLocation W42917111221 @default.
- W4291711122 hasRelatedWork W2048418896 @default.
- W4291711122 hasRelatedWork W2063379114 @default.
- W4291711122 hasRelatedWork W2144403655 @default.
- W4291711122 hasRelatedWork W2213996271 @default.
- W4291711122 hasRelatedWork W2979806364 @default.
- W4291711122 hasRelatedWork W3023991191 @default.
- W4291711122 hasRelatedWork W3087872028 @default.
- W4291711122 hasRelatedWork W3124020225 @default.
- W4291711122 hasRelatedWork W3214998341 @default.