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• W4291736623 endingPage "103665" @default.
• W4291736623 startingPage "103665" @default.
• W4291736623 abstract "Polysaccharide-based nanocarriers such as nanogels have recently received considerable attention in modified drug delivery due to their biocompatibility and biodegradability. However, the application of the nanocarriers was limited due to longer preparation time, usage of large amounts of organic solvents and surfactants as well as lower drug loading capacity (LC) and encapsulation efficiency (EE). In this study, nanogels were prepared from carboxymethyl nanocellulose (CMNC)-lysozyme blends in aqueous phase via electrostatic interaction, a simple and surfactant-free approach, for sustaining drug release with better LC and EE. The nanogels were investigated in terms of size, polydispersity index (PDI), turbidity, colloidal and thermal stabilities, chemical functionality, morphology, crystallinity, LC, EE, and in vitro release patterns of different Biopharmaceutics Classification System (BCS) class drugs (acyclovir, carbamazepine, and furosemide). At pH 7.4 and above, nanogels remained in collapse state through strong electrostatic interaction between the polyelectrolytes, followed by the intramolecular H-bonding for further reduction of the size of the nanogels. Spherical nanogels in the size of <110 nm with PDI <0.2, and large zeta potential ranging from −38 to −55 mV were prepared at optimal condition (at 1:1 wt ratio of CMNC:lysozyme, heating temperature and time: 75 °C and 30 min, pH 7.4). The size and PDI of the nanogels were significantly affected by the weight ratios of CMNC-lysozyme, pH, sonication and heating times (p < 0.01), but not much affected by drug loading and storage conditions. The nanogels demonstrated high EE (62–94%) and LC (18–27%), and sustained release (48–80%) profiles of the model drugs over 12 h. These results suggest that the synthesized nanocellulose-based nanogels following easy and green preparation approach exhibited attractive properties with respect to the size, PDI, zeta potential, shape, thermal stability, EE, LC, and versatility for encapsulating and sustaining different BCS class drugs." @default.
• W4291736623 created "2022-08-16" @default.
• W4291736623 creator A5022353466 @default.
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• W4291736623 date "2022-09-01" @default.
• W4291736623 modified "2023-10-16" @default.
• W4291736623 title "Nanocellulose-based nanogels for sustained drug delivery: Preparation, characterization and in vitro evaluation" @default.
• W4291736623 cites W1135052906 @default.
• W4291736623 cites W1919388396 @default.
• W4291736623 cites W1965772500 @default.
• W4291736623 cites W1972847156 @default.
• W4291736623 cites W1990440588 @default.
• W4291736623 cites W1998020561 @default.
• W4291736623 cites W2002322102 @default.
• W4291736623 cites W2011301977 @default.
• W4291736623 cites W2021051654 @default.
• W4291736623 cites W2026494627 @default.
• W4291736623 cites W2028091603 @default.
• W4291736623 cites W2032717460 @default.
• W4291736623 cites W2033680012 @default.
• W4291736623 cites W2045151148 @default.
• W4291736623 cites W2048123135 @default.
• W4291736623 cites W2053751523 @default.
• W4291736623 cites W2062450561 @default.
• W4291736623 cites W2067381870 @default.
• W4291736623 cites W2071383434 @default.
• W4291736623 cites W2073635482 @default.
• W4291736623 cites W2084438625 @default.
• W4291736623 cites W2091096026 @default.
• W4291736623 cites W2094488030 @default.
• W4291736623 cites W2096991082 @default.
• W4291736623 cites W2115468050 @default.
• W4291736623 cites W2144175913 @default.
• W4291736623 cites W215397455 @default.
• W4291736623 cites W2170755394 @default.
• W4291736623 cites W2210070778 @default.
• W4291736623 cites W2214476018 @default.
• W4291736623 cites W2218493949 @default.
• W4291736623 cites W2302585217 @default.
• W4291736623 cites W2307793885 @default.
• W4291736623 cites W2320119486 @default.
• W4291736623 cites W2325855138 @default.
• W4291736623 cites W2441017351 @default.
• W4291736623 cites W2503552888 @default.
• W4291736623 cites W2511274381 @default.
• W4291736623 cites W2544632459 @default.
• W4291736623 cites W2548863366 @default.
• W4291736623 cites W2556469499 @default.
• W4291736623 cites W2586816391 @default.
• W4291736623 cites W2611567783 @default.
• W4291736623 cites W2612735326 @default.
• W4291736623 cites W2731887939 @default.
• W4291736623 cites W2795299846 @default.
• W4291736623 cites W2799552254 @default.
• W4291736623 cites W2802326260 @default.
• W4291736623 cites W2808032857 @default.
• W4291736623 cites W2808522996 @default.
• W4291736623 cites W2810710420 @default.
• W4291736623 cites W2889261508 @default.
• W4291736623 cites W2890119737 @default.
• W4291736623 cites W2918558093 @default.
• W4291736623 cites W2928621734 @default.
• W4291736623 cites W2951043582 @default.
• W4291736623 cites W2975218214 @default.
• W4291736623 cites W2999066200 @default.
• W4291736623 cites W2999829767 @default.
• W4291736623 cites W3008059324 @default.
• W4291736623 cites W3012227215 @default.
• W4291736623 cites W3022429852 @default.
• W4291736623 cites W3024856375 @default.
• W4291736623 cites W3025753412 @default.
• W4291736623 cites W3031962250 @default.
• W4291736623 cites W3040583611 @default.
• W4291736623 cites W3043896012 @default.
• W4291736623 cites W3044475806 @default.
• W4291736623 cites W3082962897 @default.
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• W4291736623 cites W3111389715 @default.
• W4291736623 cites W3132248842 @default.
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• W4291736623 doi "https://doi.org/10.1016/j.jddst.2022.103665" @default.
• W4291736623 hasPublicationYear "2022" @default.
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