FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291778880> ?p ?o ?g. }

• W4291778880 endingPage "1695" @default.
• W4291778880 startingPage "1695" @default.
• W4291778880 abstract "Delivering high-molecular-weight hydrophobic peptides, such as cyclosporine A, across the corneal epithelium remains a challenge that is complicated by other physio-anatomical ocular structures that limit the ocular bioavailability of such peptides. Transferosomes have previously been used to improve transdermal permeability, and have the potential for improving the ocular corneal permeability of applicable drugs. In this study, transferosomes for the potential ocular delivery of cyclosporine A were investigated. Linoleic acid was evaluated for its effect on the stability of the transferosomes and was substituted for a portion of the cholesterol in the vesicles. Additionally, Span® 80 and Tween® 80 were evaluated for their effect on transferosome flexibility and toxicity to ocular cells as edge activators. Attenuated Total Reflectance-Fourier Transform Infrared spectroscopy (ATF-FTIR), differential scanning calorimetry (DSC), and dynamic light scattering (DLS) were used to evaluate the physicochemical parameters of the blank and the cyclosporine A-loaded transferosomes. Cyclosporine A release and corneal permeability were studied in vitro and in a New Zealand albino rabbit corneal model, respectively. The linoleic acid contributed to improved stability and the nano-size of the transferosomes. The Tween®-based formulation was preferred on the basis of a more favorable toxicity profile, as the difference in their corneal permeability was not significant. There was an initial burst release of cyclosporine A in the first 24 h that plateaued over one week. The Tween®-based formulation had a flux of 0.78 µg/cm2/h. The prepared transferosomes demonstrated biocompatibility in the ocular cell line, adequately encapsulated cyclosporine A, ensured the corneal permeability of the enclosed drug, and were stable over the period of investigation of 4 months at -20 °C." @default.
• W4291778880 created "2022-08-16" @default.
• W4291778880 creator A5003185613 @default.
• W4291778880 creator A5008780473 @default.
• W4291778880 creator A5009067167 @default.
• W4291778880 creator A5054570112 @default.
• W4291778880 creator A5076703528 @default.
• W4291778880 date "2022-08-15" @default.
• W4291778880 modified "2023-09-30" @default.
• W4291778880 title "Linoleic Acid-Based Transferosomes for Topical Ocular Delivery of Cyclosporine A" @default.
• W4291778880 cites W1987369876 @default.
• W4291778880 cites W1988801567 @default.
• W4291778880 cites W1990107938 @default.
• W4291778880 cites W1997211780 @default.
• W4291778880 cites W2001119625 @default.
• W4291778880 cites W2003836488 @default.
• W4291778880 cites W2004165733 @default.
• W4291778880 cites W2004957965 @default.
• W4291778880 cites W2007044831 @default.
• W4291778880 cites W2014760109 @default.
• W4291778880 cites W2031671434 @default.
• W4291778880 cites W2043502318 @default.
• W4291778880 cites W2044806297 @default.
• W4291778880 cites W2054872615 @default.
• W4291778880 cites W2057373762 @default.
• W4291778880 cites W2066209686 @default.
• W4291778880 cites W2071746665 @default.
• W4291778880 cites W2080378806 @default.
• W4291778880 cites W2126415418 @default.
• W4291778880 cites W2150900483 @default.
• W4291778880 cites W2160760798 @default.
• W4291778880 cites W2162221036 @default.
• W4291778880 cites W2210288065 @default.
• W4291778880 cites W2570367121 @default.
• W4291778880 cites W2584902226 @default.
• W4291778880 cites W2591969453 @default.
• W4291778880 cites W2594674486 @default.
• W4291778880 cites W2603809109 @default.
• W4291778880 cites W2784031181 @default.
• W4291778880 cites W2795425067 @default.
• W4291778880 cites W2797901882 @default.
• W4291778880 cites W2811943604 @default.
• W4291778880 cites W2895888065 @default.
• W4291778880 cites W2907476832 @default.
• W4291778880 cites W2909808912 @default.
• W4291778880 cites W2949501141 @default.
• W4291778880 cites W2957374179 @default.
• W4291778880 cites W2979092709 @default.
• W4291778880 cites W2992912462 @default.
• W4291778880 cites W2999926766 @default.
• W4291778880 cites W3004456848 @default.
• W4291778880 cites W3007031689 @default.
• W4291778880 cites W3045183872 @default.
• W4291778880 cites W3083987393 @default.
• W4291778880 cites W3093773676 @default.
• W4291778880 cites W3107157944 @default.
• W4291778880 cites W3121839737 @default.
• W4291778880 cites W3159032052 @default.
• W4291778880 cites W3190004370 @default.
• W4291778880 cites W3200613212 @default.
• W4291778880 cites W4200282408 @default.
• W4291778880 cites W4291923002 @default.
• W4291778880 cites W1970472216 @default.
• W4291778880 doi "https://doi.org/10.3390/pharmaceutics14081695" @default.
• W4291778880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36015321" @default.
• W4291778880 hasPublicationYear "2022" @default.
• W4291778880 type Work @default.
• W4291778880 citedByCount "3" @default.
• W4291778880 countsByYear W42917788802023 @default.
• W4291778880 crossrefType "journal-article" @default.
• W4291778880 hasAuthorship W4291778880A5003185613 @default.
• W4291778880 hasAuthorship W4291778880A5008780473 @default.
• W4291778880 hasAuthorship W4291778880A5009067167 @default.
• W4291778880 hasAuthorship W4291778880A5054570112 @default.
• W4291778880 hasAuthorship W4291778880A5076703528 @default.
• W4291778880 hasBestOaLocation W42917788801 @default.
• W4291778880 hasConcept C118487528 @default.
• W4291778880 hasConcept C153642686 @default.
• W4291778880 hasConcept C178790620 @default.
• W4291778880 hasConcept C181389837 @default.
• W4291778880 hasConcept C185592680 @default.
• W4291778880 hasConcept C2776882836 @default.
• W4291778880 hasConcept C2777230088 @default.
• W4291778880 hasConcept C2777625524 @default.
• W4291778880 hasConcept C2779257441 @default.
• W4291778880 hasConcept C29730261 @default.
• W4291778880 hasConcept C49102809 @default.
• W4291778880 hasConcept C71924100 @default.
• W4291778880 hasConcept C98274493 @default.
• W4291778880 hasConceptScore W4291778880C118487528 @default.
• W4291778880 hasConceptScore W4291778880C153642686 @default.
• W4291778880 hasConceptScore W4291778880C178790620 @default.
• W4291778880 hasConceptScore W4291778880C181389837 @default.
• W4291778880 hasConceptScore W4291778880C185592680 @default.
• W4291778880 hasConceptScore W4291778880C2776882836 @default.
• W4291778880 hasConceptScore W4291778880C2777230088 @default.
• W4291778880 hasConceptScore W4291778880C2777625524 @default.
• W4291778880 hasConceptScore W4291778880C2779257441 @default.

• next