Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291885991> ?p ?o ?g. }
- W4291885991 endingPage "4749" @default.
- W4291885991 startingPage "4749" @default.
- W4291885991 abstract "Circulating osteogenic precursor (COP) cells are peripheral blood cells with a capacity for osteogenesis. The objective of our study was to ascertain the percentage of COPs as an early biomarker of osteoporosis and the effect of these cells in response to Denosumab (DmAb) (anti-resorptive) or to Teriparatide (TPDP) (anabolic) as very effective drugs in the treatment of the illness. A first study was conducted on healthy volunteers, with three age ranges, to determine the percentage of COPs and relate it to their anthropometric and biochemical characteristics, followed by a second longitudinal study on patients with osteoporosis, whereby one group of patients was treated with TPTD and another with DmAb. All were analyzed by cytometry for COP percentage in blood, bone turnover markers, and bone mass. Our findings show that COPs are influenced by age and become more prolific in the stages of growth and skeletal maturation. A higher percentage of COPs is found in osteoporotic disease, which could constitute a predictive marker thereof. We also show how treatment with TPTD or DmAb mobilizes circulating osteogenic precursors in the blood. Significant increases in % COPs were observed after 12 months of treatment with Dmb (21.9%) and TPTD (17%). These results can be related to an increase in osteogenesis and, consequently, a better and more efficient repair of bone tissue." @default.
- W4291885991 created "2022-08-16" @default.
- W4291885991 creator A5002782612 @default.
- W4291885991 creator A5013620258 @default.
- W4291885991 creator A5025500697 @default.
- W4291885991 creator A5027609902 @default.
- W4291885991 creator A5033788945 @default.
- W4291885991 creator A5047956646 @default.
- W4291885991 creator A5059193560 @default.
- W4291885991 creator A5068115605 @default.
- W4291885991 date "2022-08-14" @default.
- W4291885991 modified "2023-10-18" @default.
- W4291885991 title "Circulating Osteogenic Progenitor Cells Enhanced with Teriparatide or Denosumab Treatment" @default.
- W4291885991 cites W1849546311 @default.
- W4291885991 cites W1965180760 @default.
- W4291885991 cites W1974815597 @default.
- W4291885991 cites W1981833135 @default.
- W4291885991 cites W1992239128 @default.
- W4291885991 cites W2000779652 @default.
- W4291885991 cites W2014827262 @default.
- W4291885991 cites W2015214016 @default.
- W4291885991 cites W2052673490 @default.
- W4291885991 cites W2066375889 @default.
- W4291885991 cites W2070000741 @default.
- W4291885991 cites W2094733192 @default.
- W4291885991 cites W2150286991 @default.
- W4291885991 cites W2160005424 @default.
- W4291885991 cites W2574774326 @default.
- W4291885991 cites W2592743107 @default.
- W4291885991 cites W2619448414 @default.
- W4291885991 cites W2622007407 @default.
- W4291885991 cites W2891821120 @default.
- W4291885991 cites W2896300986 @default.
- W4291885991 cites W2899569070 @default.
- W4291885991 cites W2902528137 @default.
- W4291885991 cites W2909070195 @default.
- W4291885991 cites W2915400346 @default.
- W4291885991 cites W2954020197 @default.
- W4291885991 cites W3006047073 @default.
- W4291885991 cites W3013665133 @default.
- W4291885991 cites W3095472573 @default.
- W4291885991 cites W3109774147 @default.
- W4291885991 cites W3120383256 @default.
- W4291885991 cites W3202786550 @default.
- W4291885991 cites W3215742619 @default.
- W4291885991 doi "https://doi.org/10.3390/jcm11164749" @default.
- W4291885991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36012987" @default.
- W4291885991 hasPublicationYear "2022" @default.
- W4291885991 type Work @default.
- W4291885991 citedByCount "1" @default.
- W4291885991 countsByYear W42918859912023 @default.
- W4291885991 crossrefType "journal-article" @default.
- W4291885991 hasAuthorship W4291885991A5002782612 @default.
- W4291885991 hasAuthorship W4291885991A5013620258 @default.
- W4291885991 hasAuthorship W4291885991A5025500697 @default.
- W4291885991 hasAuthorship W4291885991A5027609902 @default.
- W4291885991 hasAuthorship W4291885991A5033788945 @default.
- W4291885991 hasAuthorship W4291885991A5047956646 @default.
- W4291885991 hasAuthorship W4291885991A5059193560 @default.
- W4291885991 hasAuthorship W4291885991A5068115605 @default.
- W4291885991 hasBestOaLocation W42918859911 @default.
- W4291885991 hasConcept C1008401 @default.
- W4291885991 hasConcept C126322002 @default.
- W4291885991 hasConcept C134018914 @default.
- W4291885991 hasConcept C170033053 @default.
- W4291885991 hasConcept C185592680 @default.
- W4291885991 hasConcept C201750760 @default.
- W4291885991 hasConcept C2776286101 @default.
- W4291885991 hasConcept C2776541429 @default.
- W4291885991 hasConcept C2776886416 @default.
- W4291885991 hasConcept C2777308945 @default.
- W4291885991 hasConcept C2781197716 @default.
- W4291885991 hasConcept C28328180 @default.
- W4291885991 hasConcept C55493867 @default.
- W4291885991 hasConcept C71924100 @default.
- W4291885991 hasConcept C86803240 @default.
- W4291885991 hasConcept C95444343 @default.
- W4291885991 hasConceptScore W4291885991C1008401 @default.
- W4291885991 hasConceptScore W4291885991C126322002 @default.
- W4291885991 hasConceptScore W4291885991C134018914 @default.
- W4291885991 hasConceptScore W4291885991C170033053 @default.
- W4291885991 hasConceptScore W4291885991C185592680 @default.
- W4291885991 hasConceptScore W4291885991C201750760 @default.
- W4291885991 hasConceptScore W4291885991C2776286101 @default.
- W4291885991 hasConceptScore W4291885991C2776541429 @default.
- W4291885991 hasConceptScore W4291885991C2776886416 @default.
- W4291885991 hasConceptScore W4291885991C2777308945 @default.
- W4291885991 hasConceptScore W4291885991C2781197716 @default.
- W4291885991 hasConceptScore W4291885991C28328180 @default.
- W4291885991 hasConceptScore W4291885991C55493867 @default.
- W4291885991 hasConceptScore W4291885991C71924100 @default.
- W4291885991 hasConceptScore W4291885991C86803240 @default.
- W4291885991 hasConceptScore W4291885991C95444343 @default.
- W4291885991 hasIssue "16" @default.
- W4291885991 hasLocation W42918859911 @default.
- W4291885991 hasLocation W42918859912 @default.
- W4291885991 hasLocation W42918859913 @default.
- W4291885991 hasLocation W42918859914 @default.