Matches in SemOpenAlex for { <https://semopenalex.org/work/W4291935231> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W4291935231 endingPage "9" @default.
- W4291935231 startingPage "138" @default.
- W4291935231 abstract "(1) Many treatments are available for actinic keratosis. The most widely used is cryotherapy. Topical application of 5% fluorouracil cream is a second-line option. (2) Marketing authorisation has been granted for a topical gel containing 3% diclofenac, a nonsteroidal antiinflammatory drug. The excipients include 2.5% hyaluronic acid. (3) Animal pharmacology studies and in vitro tests show that hyaluronic acid delays the transcutaneous uptake of diclofenac, leading to higher concentrations in the epidermis. (4) No comparative trials with fluorouracil or other drugs have been published. Five trials comparing 3% diclofenac topical gel with its excipient are available. They show that it takes at least two or three months of treatment for the lesions to disappear in one-third to one-half of patients. Indirect comparison suggests that diclofenac is less effective than fluorouracil in terms of lesion disappearance one month after the end of treatment. The subsequent risk of relapse is unknown. (5) Local adverse effects are numerous and frequent, and include contact dermatitis, skin rash, dry skin, desquamation, pruritus, local pain, and paresthesia. Adverse effects can be due to either diclofenac or to the excipient, and seem to be less intense than with topical fluorouracil. (6) Trials have shown that topical diclofenac is effective at a dose of 0.5 g of gel applied twice a day, but this precise dose is unlikely to be used as no measuring device is included in the packaging. (7) In practice, diclofenac topical gel is less effective than fluorouracil, and is only a moderately effective option when fluorouracil is poorly tolerated and when physical treatments such as cryotherapy fail." @default.
- W4291935231 created "2022-08-16" @default.
- W4291935231 date "2004-08-01" @default.
- W4291935231 modified "2023-10-18" @default.
- W4291935231 title "Topical diclofenac: new preparation. Moderate efficacy in actinic keratosis." @default.
- W4291935231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15532138" @default.
- W4291935231 hasPublicationYear "2004" @default.
- W4291935231 type Work @default.
- W4291935231 citedByCount "0" @default.
- W4291935231 crossrefType "journal-article" @default.
- W4291935231 hasConcept C126322002 @default.
- W4291935231 hasConcept C141071460 @default.
- W4291935231 hasConcept C16005928 @default.
- W4291935231 hasConcept C197934379 @default.
- W4291935231 hasConcept C2776694085 @default.
- W4291935231 hasConcept C2777035695 @default.
- W4291935231 hasConcept C2777239854 @default.
- W4291935231 hasConcept C2777873816 @default.
- W4291935231 hasConcept C2779826273 @default.
- W4291935231 hasConcept C2780149145 @default.
- W4291935231 hasConcept C2780456651 @default.
- W4291935231 hasConcept C3019992690 @default.
- W4291935231 hasConcept C71924100 @default.
- W4291935231 hasConcept C98274493 @default.
- W4291935231 hasConceptScore W4291935231C126322002 @default.
- W4291935231 hasConceptScore W4291935231C141071460 @default.
- W4291935231 hasConceptScore W4291935231C16005928 @default.
- W4291935231 hasConceptScore W4291935231C197934379 @default.
- W4291935231 hasConceptScore W4291935231C2776694085 @default.
- W4291935231 hasConceptScore W4291935231C2777035695 @default.
- W4291935231 hasConceptScore W4291935231C2777239854 @default.
- W4291935231 hasConceptScore W4291935231C2777873816 @default.
- W4291935231 hasConceptScore W4291935231C2779826273 @default.
- W4291935231 hasConceptScore W4291935231C2780149145 @default.
- W4291935231 hasConceptScore W4291935231C2780456651 @default.
- W4291935231 hasConceptScore W4291935231C3019992690 @default.
- W4291935231 hasConceptScore W4291935231C71924100 @default.
- W4291935231 hasConceptScore W4291935231C98274493 @default.
- W4291935231 hasIssue "72" @default.
- W4291935231 hasLocation W42919352311 @default.
- W4291935231 hasOpenAccess W4291935231 @default.
- W4291935231 hasPrimaryLocation W42919352311 @default.
- W4291935231 hasRelatedWork W1876826546 @default.
- W4291935231 hasRelatedWork W1988990009 @default.
- W4291935231 hasRelatedWork W2012464070 @default.
- W4291935231 hasRelatedWork W2103916895 @default.
- W4291935231 hasRelatedWork W2150345294 @default.
- W4291935231 hasRelatedWork W2397821905 @default.
- W4291935231 hasRelatedWork W2401868130 @default.
- W4291935231 hasRelatedWork W28058393 @default.
- W4291935231 hasRelatedWork W2893248400 @default.
- W4291935231 hasRelatedWork W3186308999 @default.
- W4291935231 hasVolume "13" @default.
- W4291935231 isParatext "false" @default.
- W4291935231 isRetracted "false" @default.
- W4291935231 workType "article" @default.