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- W4291991161 abstract "Spermidine is essential for cellular growth and acts as a prerequisite of hypusination, a post-translational modification of eukaryotic initiation factor 5A (eIF5A), allowing the translation of polyproline-containing proteins. Here, we show that oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV) increases spermidine synthesis and eIF5A hypusination to enhance expression of polyproline-containing latency-associated nuclear antigen (LANA) for viral episomal maintenance. KSHV upregulates intracellular spermidine levels by dysregulating polyamine metabolic pathways in three-dimensional (3D) culture and 2D de novo infection conditions. Increased intracellular spermidine leads to increased eIF5A hypusination, ultimately enhancing LANA expression. In contrast, inhibition of spermidine synthesis or eIF5A hypusination alleviates LANA expression, decreasing viral episomal maintenance and KSHV-infected cell proliferation in vitro and in vivo, which is reversed by spermidine supplement. This demonstrates that KSHV hijacks spermidine synthesis and eIF5A hypusination pathways to enhance LANA expression for viral episomal maintenance, suggesting polyamine metabolism and eIF5A hypusination as therapeutic targets for KSHV-induced tumorigenesis." @default.
- W4291991161 created "2022-08-16" @default.
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- W4291991161 date "2022-08-01" @default.
- W4291991161 modified "2023-10-15" @default.
- W4291991161 title "Herpesvirus-induced spermidine synthesis and eIF5A hypusination for viral episomal maintenance" @default.
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- W4291991161 cites W1968202347 @default.
- W4291991161 cites W1968899052 @default.
- W4291991161 cites W1971536332 @default.
- W4291991161 cites W1976954198 @default.
- W4291991161 cites W1982172428 @default.
- W4291991161 cites W1983788160 @default.
- W4291991161 cites W1991407392 @default.
- W4291991161 cites W1992808621 @default.
- W4291991161 cites W1999722691 @default.
- W4291991161 cites W2008004643 @default.
- W4291991161 cites W2014489014 @default.
- W4291991161 cites W2014782775 @default.
- W4291991161 cites W2015893533 @default.
- W4291991161 cites W2017517248 @default.
- W4291991161 cites W2022399382 @default.
- W4291991161 cites W2025994995 @default.
- W4291991161 cites W2028953339 @default.
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- W4291991161 cites W2074412163 @default.
- W4291991161 cites W2074454759 @default.
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- W4291991161 cites W2160426448 @default.
- W4291991161 cites W2162016300 @default.
- W4291991161 cites W2162978930 @default.
- W4291991161 cites W2164846110 @default.
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- W4291991161 cites W2171634093 @default.
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- W4291991161 cites W2884154642 @default.
- W4291991161 cites W2978170629 @default.
- W4291991161 cites W3004060585 @default.
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- W4291991161 doi "https://doi.org/10.1016/j.celrep.2022.111234" @default.
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