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- W4291994076 abstract "Abstract Safe and effective use of drugs requires an understanding of metabolism and transport. We identified the 100 most prescribed drugs in six countries and conducted a literature search on in vitro data to assess contribution of Phase I and II enzymes and drug transporters to metabolism and transport. Eighty‐nine of the 100 drugs undergo drug metabolism or are known substrates for drug transporters. Phase I enzymes are involved in metabolism of 67 drugs, while Phase II enzymes mediate metabolism of 18 drugs. CYP3A4/5 is the most important Phase I enzyme involved in metabolism of 43 drugs followed by CYP2D6 (23 drugs), CYP2C9 (23 drugs), CYP2C19 (22 drugs), CYP1A2 (14 drugs) and CYP2C8 (11 drugs). More than half of the drugs (54 drugs) are known substrates for drug transporters. P‐glycoprotein (P‐gp) is known to be involved in transport of 30 drugs, while breast cancer resistance protein (BCRP) facilitates transport of 11 drugs. A considerable proportion of drugs are subject to a combination of Phase I metabolism, Phase II metabolism and/or drug transport. We conclude that the majority of the most frequently prescribed drugs depend on drug metabolism or drug transport. Thus, understanding variability of drug metabolism and transport remains a priority." @default.
- W4291994076 created "2022-08-16" @default.
- W4291994076 creator A5002442735 @default.
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- W4291994076 creator A5090555792 @default.
- W4291994076 date "2022-08-24" @default.
- W4291994076 modified "2023-10-04" @default.
- W4291994076 title "Drug metabolism and drug transport of the 100 most prescribed oral drugs" @default.
- W4291994076 cites W1527978887 @default.
- W4291994076 cites W1575158876 @default.
- W4291994076 cites W1599481453 @default.
- W4291994076 cites W1783939843 @default.
- W4291994076 cites W1969795656 @default.
- W4291994076 cites W1971325740 @default.
- W4291994076 cites W1972996926 @default.
- W4291994076 cites W1976568296 @default.
- W4291994076 cites W1982128407 @default.
- W4291994076 cites W1985777098 @default.
- W4291994076 cites W1993198959 @default.
- W4291994076 cites W1997815372 @default.
- W4291994076 cites W2002115210 @default.
- W4291994076 cites W2003562401 @default.
- W4291994076 cites W2004146675 @default.
- W4291994076 cites W2010427019 @default.
- W4291994076 cites W2012034410 @default.
- W4291994076 cites W2016318120 @default.
- W4291994076 cites W2025779989 @default.
- W4291994076 cites W2031047120 @default.
- W4291994076 cites W2033139608 @default.
- W4291994076 cites W2034590656 @default.
- W4291994076 cites W2035855164 @default.
- W4291994076 cites W2041242529 @default.
- W4291994076 cites W2044906812 @default.
- W4291994076 cites W2058864601 @default.
- W4291994076 cites W2061003736 @default.
- W4291994076 cites W2066312456 @default.
- W4291994076 cites W2068780263 @default.
- W4291994076 cites W2076985436 @default.
- W4291994076 cites W2077136462 @default.
- W4291994076 cites W2081171675 @default.
- W4291994076 cites W2091234451 @default.
- W4291994076 cites W2092296126 @default.
- W4291994076 cites W2104243204 @default.
- W4291994076 cites W2108821399 @default.
- W4291994076 cites W2109989116 @default.
- W4291994076 cites W2115459289 @default.
- W4291994076 cites W2115763439 @default.
- W4291994076 cites W2118342649 @default.
- W4291994076 cites W2119494065 @default.
- W4291994076 cites W2121074897 @default.
- W4291994076 cites W2125949013 @default.
- W4291994076 cites W2128138742 @default.
- W4291994076 cites W2128189669 @default.
- W4291994076 cites W2131138924 @default.
- W4291994076 cites W2138509705 @default.
- W4291994076 cites W2157839219 @default.
- W4291994076 cites W2158671268 @default.
- W4291994076 cites W2160330932 @default.
- W4291994076 cites W2161587482 @default.
- W4291994076 cites W2161835881 @default.
- W4291994076 cites W2162787841 @default.
- W4291994076 cites W2168137791 @default.
- W4291994076 cites W2290303106 @default.
- W4291994076 cites W2345433402 @default.
- W4291994076 cites W237900477 @default.
- W4291994076 cites W2397302600 @default.
- W4291994076 cites W2466409227 @default.
- W4291994076 cites W2509702692 @default.
- W4291994076 cites W2528806650 @default.
- W4291994076 cites W2541211648 @default.
- W4291994076 cites W2588108371 @default.
- W4291994076 cites W2590206251 @default.
- W4291994076 cites W2596388826 @default.
- W4291994076 cites W2617096152 @default.
- W4291994076 cites W2737221336 @default.
- W4291994076 cites W2759415648 @default.
- W4291994076 cites W2765589989 @default.
- W4291994076 cites W2770421577 @default.
- W4291994076 cites W2790223071 @default.
- W4291994076 cites W2792879327 @default.
- W4291994076 cites W2886548944 @default.
- W4291994076 cites W2892275496 @default.
- W4291994076 cites W2914241247 @default.
- W4291994076 cites W2922035491 @default.
- W4291994076 cites W2928722422 @default.
- W4291994076 cites W2936583579 @default.
- W4291994076 cites W2976234849 @default.
- W4291994076 cites W2983839179 @default.
- W4291994076 cites W3007489417 @default.
- W4291994076 cites W3016549119 @default.
- W4291994076 cites W3032314402 @default.
- W4291994076 cites W3048277970 @default.
- W4291994076 cites W3081633135 @default.
- W4291994076 cites W3099007929 @default.
- W4291994076 cites W3114326816 @default.
- W4291994076 cites W3173022441 @default.