Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292005251> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4292005251 endingPage "3" @default.
- W4292005251 startingPage "50" @default.
- W4292005251 abstract "(1) The standard hormonal contraception consists of a combined oral contraceptive containing about 30 micrograms of ethinylestradiol and a well-evaluated and widely used progestin such as levonorgestrel or norethisterone. (2) A vaginal ring delivering about 120 micrograms of etonogestrel and 15 micrograms of ethinylestradiol daily for 3 consecutive weeks per cycle, which is then removed for one week, is now marketed in France as a contraceptive. Etonogestrel, a desogestrel metabolite, is classified as a 'third-generation' progestin. (3) On the basis of 2 non-comparative trials involving a total of 2322 women, the vaginal ring's contraceptive efficacy, as measured by the Pearl index, is about 1 per 100 woman-years, a value similar to that of other available combined hormonal contraceptives. (4) In total, 41% and 29.6% of women withdrew early from each of the two trials. In the two trials combined, 15.6% of women withdrew due to adverse events. (5) A comparative trial versus oral ethinylestradiol + levonorgestrel showed no difference in adherence rates, and similar Pearl index scores. (6) The most frequent adverse effects, occurring in about 20% of women using the vaginal ring, were gynecological disorders (vaginitis, leukorrhea or local discomfort). The other adverse effects were those common to all hormonal contraceptives. (7) The thromboembolic risk of etonogestrel, when administered in a contraceptive ring, has not been evaluated. (8) In practice, the standard hormonal contraceptive remains a combined oral contraceptive containing about 30 micrograms of ethinylestradiol plus a well-evaluated progestin such as levonorgestrel or norethisterone. The vaginal ring offers no advantage in terms of efficacy, adverse effects or adherence. However, it is an additional effective contraceptive and may be preferred by some women, at least temporarily, in certain situations." @default.
- W4292005251 created "2022-08-16" @default.
- W4292005251 date "2006-04-01" @default.
- W4292005251 modified "2023-10-18" @default.
- W4292005251 title "Ethinylestradiol + etonogestrel contraceptive vaginal ring: new drug. Possibly useful in some situations." @default.
- W4292005251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16604729" @default.
- W4292005251 hasPublicationYear "2006" @default.
- W4292005251 type Work @default.
- W4292005251 citedByCount "0" @default.
- W4292005251 crossrefType "journal-article" @default.
- W4292005251 hasConcept C126322002 @default.
- W4292005251 hasConcept C131872663 @default.
- W4292005251 hasConcept C141071460 @default.
- W4292005251 hasConcept C197934379 @default.
- W4292005251 hasConcept C2776172332 @default.
- W4292005251 hasConcept C2776607906 @default.
- W4292005251 hasConcept C2777164284 @default.
- W4292005251 hasConcept C2777744392 @default.
- W4292005251 hasConcept C2777956591 @default.
- W4292005251 hasConcept C2778723060 @default.
- W4292005251 hasConcept C2779076696 @default.
- W4292005251 hasConcept C2779441745 @default.
- W4292005251 hasConcept C2779755712 @default.
- W4292005251 hasConcept C2780186607 @default.
- W4292005251 hasConcept C2780330700 @default.
- W4292005251 hasConcept C2780835420 @default.
- W4292005251 hasConcept C2781039349 @default.
- W4292005251 hasConcept C2781197234 @default.
- W4292005251 hasConcept C2908647359 @default.
- W4292005251 hasConcept C29456083 @default.
- W4292005251 hasConcept C2986740045 @default.
- W4292005251 hasConcept C2986817661 @default.
- W4292005251 hasConcept C71924100 @default.
- W4292005251 hasConcept C99454951 @default.
- W4292005251 hasConceptScore W4292005251C126322002 @default.
- W4292005251 hasConceptScore W4292005251C131872663 @default.
- W4292005251 hasConceptScore W4292005251C141071460 @default.
- W4292005251 hasConceptScore W4292005251C197934379 @default.
- W4292005251 hasConceptScore W4292005251C2776172332 @default.
- W4292005251 hasConceptScore W4292005251C2776607906 @default.
- W4292005251 hasConceptScore W4292005251C2777164284 @default.
- W4292005251 hasConceptScore W4292005251C2777744392 @default.
- W4292005251 hasConceptScore W4292005251C2777956591 @default.
- W4292005251 hasConceptScore W4292005251C2778723060 @default.
- W4292005251 hasConceptScore W4292005251C2779076696 @default.
- W4292005251 hasConceptScore W4292005251C2779441745 @default.
- W4292005251 hasConceptScore W4292005251C2779755712 @default.
- W4292005251 hasConceptScore W4292005251C2780186607 @default.
- W4292005251 hasConceptScore W4292005251C2780330700 @default.
- W4292005251 hasConceptScore W4292005251C2780835420 @default.
- W4292005251 hasConceptScore W4292005251C2781039349 @default.
- W4292005251 hasConceptScore W4292005251C2781197234 @default.
- W4292005251 hasConceptScore W4292005251C2908647359 @default.
- W4292005251 hasConceptScore W4292005251C29456083 @default.
- W4292005251 hasConceptScore W4292005251C2986740045 @default.
- W4292005251 hasConceptScore W4292005251C2986817661 @default.
- W4292005251 hasConceptScore W4292005251C71924100 @default.
- W4292005251 hasConceptScore W4292005251C99454951 @default.
- W4292005251 hasIssue "82" @default.
- W4292005251 hasLocation W42920052511 @default.
- W4292005251 hasOpenAccess W4292005251 @default.
- W4292005251 hasPrimaryLocation W42920052511 @default.
- W4292005251 hasRelatedWork W1634526586 @default.
- W4292005251 hasRelatedWork W1849526933 @default.
- W4292005251 hasRelatedWork W1851671157 @default.
- W4292005251 hasRelatedWork W1998180552 @default.
- W4292005251 hasRelatedWork W2018109309 @default.
- W4292005251 hasRelatedWork W2021425072 @default.
- W4292005251 hasRelatedWork W2034522124 @default.
- W4292005251 hasRelatedWork W2282470798 @default.
- W4292005251 hasRelatedWork W2300763421 @default.
- W4292005251 hasRelatedWork W1717944144 @default.
- W4292005251 hasVolume "15" @default.
- W4292005251 isParatext "false" @default.
- W4292005251 isRetracted "false" @default.
- W4292005251 workType "article" @default.