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• W4292014102 abstract "During cerebral ischemia-reperfusion (I-R) injury, the infiltration of monocyte/macrophages (Mo/Mφ) into the ischemic penumbra causes inflammatory damage but also regulates tissue repair in the penumbra. The regulation and balance of Mo/Mφ polarization is considered as a potential therapeutic target for treating cerebral I-R injury. Herein, these findings demonstrate that glabridin (Gla)-loaded nanoparticles (i.e., NPGla-5k) can effectively inhibit M1-polarization and enhance M2-polarization of Mo/Mφ. Positron emission tomography (PET) imaging shows that NPGla-5k can selectively accumulate in the spleen following intravenous injection. Spleen-targeted Cy5-NPGla-5k can co-localize with peripheral macrophages in the penumbra at 24 h after tail-vein injection. Interestingly, NPGla-5k treatment can reduce inflammatory damage, protect dying neurons, and improve nervous system function. The protective effect of spleen-targeted NPGla-5k against cerebral I-R injury in mice encourages an exploration of their use for clinical treatment of patients with cerebral I-R injury." @default.
• W4292014102 created "2022-08-17" @default.
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• W4292014102 date "2022-09-01" @default.
• W4292014102 modified "2023-10-16" @default.
• W4292014102 title "Spleen‐Targeted Glabridin‐Loaded Nanoparticles Regulate Polarization of Monocyte/Macrophage ( <i>M</i> _o / <i>M</i> _φ ) for the Treatment of Cerebral Ischemia‐Reperfusion Injury" @default.
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• W4292014102 doi "https://doi.org/10.1002/adma.202204976" @default.
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