Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292061346> ?p ?o ?g. }
- W4292061346 abstract "Brain organoids are valuable research models for human development and disease since they mimic the various cell compositions and structures of the human brain; however, they have challenges in presenting aging phenotypes for degenerative diseases. This study analyzed the association between aging and the gut metabolite trimethylamine N-oxide (TMAO), which is highly found in the midbrain of elderly and Parkinson's disease (PD) patients. TMAO treatment in midbrain organoid induced aging-associated molecular changes, including increased senescence marker expression (P21, P16), p53 accumulation, and epigenetic alterations. In addition, TMAO-treated midbrain organoids have shown parts of neurodegeneration phenotypes, including impaired brain-derived neurotrophic factor (BDNF) signaling, loss of dopaminergic neurons, astrocyte activation, and neuromelanin accumulation. Moreover, we found TMAO treatment-induced pathophysiological phosphorylation of α-synuclein protein at Ser-129 residues and Tau protein at Ser202/Thr205. These results suggest a role of TMAO in the aging and pathogenesis of the midbrain and provide insight into how intestinal dysfunction increases the risk of PD. Furthermore, this system can be utilized as a novel aging model for induced pluripotent stem cell (iPSC)-based modeling of late-onset diseases." @default.
- W4292061346 created "2022-08-17" @default.
- W4292061346 creator A5042009416 @default.
- W4292061346 creator A5057614818 @default.
- W4292061346 creator A5067118584 @default.
- W4292061346 creator A5079477825 @default.
- W4292061346 creator A5082953572 @default.
- W4292061346 date "2022-08-16" @default.
- W4292061346 modified "2023-09-26" @default.
- W4292061346 title "Gut metabolite trimethylamine N-oxide induces aging-associated phenotype of midbrain organoids for the induced pluripotent stem cell-based modeling of late-onset disease" @default.
- W4292061346 cites W1913653254 @default.
- W4292061346 cites W1973921337 @default.
- W4292061346 cites W2012173754 @default.
- W4292061346 cites W2072810104 @default.
- W4292061346 cites W2073760242 @default.
- W4292061346 cites W2081914422 @default.
- W4292061346 cites W2097942030 @default.
- W4292061346 cites W2106022949 @default.
- W4292061346 cites W2108865709 @default.
- W4292061346 cites W2126525177 @default.
- W4292061346 cites W2177905053 @default.
- W4292061346 cites W2342847104 @default.
- W4292061346 cites W2407468727 @default.
- W4292061346 cites W2462036771 @default.
- W4292061346 cites W2621775373 @default.
- W4292061346 cites W2763827038 @default.
- W4292061346 cites W2768825363 @default.
- W4292061346 cites W2783990112 @default.
- W4292061346 cites W2790904397 @default.
- W4292061346 cites W2800864806 @default.
- W4292061346 cites W2806146174 @default.
- W4292061346 cites W2860743873 @default.
- W4292061346 cites W2884081989 @default.
- W4292061346 cites W2890169564 @default.
- W4292061346 cites W2892844483 @default.
- W4292061346 cites W2898537938 @default.
- W4292061346 cites W2917272302 @default.
- W4292061346 cites W2942689716 @default.
- W4292061346 cites W2968035162 @default.
- W4292061346 cites W2973552995 @default.
- W4292061346 cites W2990148695 @default.
- W4292061346 cites W3004007042 @default.
- W4292061346 cites W3004443958 @default.
- W4292061346 cites W3006897798 @default.
- W4292061346 cites W3015588107 @default.
- W4292061346 cites W3025087901 @default.
- W4292061346 cites W3027081464 @default.
- W4292061346 cites W3035991087 @default.
- W4292061346 cites W3040900020 @default.
- W4292061346 cites W3048670441 @default.
- W4292061346 cites W3082205445 @default.
- W4292061346 cites W3082564026 @default.
- W4292061346 cites W3097153787 @default.
- W4292061346 cites W3132024224 @default.
- W4292061346 cites W3154889217 @default.
- W4292061346 cites W3195214799 @default.
- W4292061346 cites W3198616044 @default.
- W4292061346 cites W3211549368 @default.
- W4292061346 cites W4210702761 @default.
- W4292061346 cites W4211032576 @default.
- W4292061346 cites W4224868124 @default.
- W4292061346 doi "https://doi.org/10.3389/fnagi.2022.925227" @default.
- W4292061346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36051303" @default.
- W4292061346 hasPublicationYear "2022" @default.
- W4292061346 type Work @default.
- W4292061346 citedByCount "3" @default.
- W4292061346 countsByYear W42920613462022 @default.
- W4292061346 countsByYear W42920613462023 @default.
- W4292061346 crossrefType "journal-article" @default.
- W4292061346 hasAuthorship W4292061346A5042009416 @default.
- W4292061346 hasAuthorship W4292061346A5057614818 @default.
- W4292061346 hasAuthorship W4292061346A5067118584 @default.
- W4292061346 hasAuthorship W4292061346A5079477825 @default.
- W4292061346 hasAuthorship W4292061346A5082953572 @default.
- W4292061346 hasBestOaLocation W42920613461 @default.
- W4292061346 hasConcept C104317684 @default.
- W4292061346 hasConcept C107459253 @default.
- W4292061346 hasConcept C126322002 @default.
- W4292061346 hasConcept C127716648 @default.
- W4292061346 hasConcept C134018914 @default.
- W4292061346 hasConcept C137183658 @default.
- W4292061346 hasConcept C145103041 @default.
- W4292061346 hasConcept C169760540 @default.
- W4292061346 hasConcept C2776149385 @default.
- W4292061346 hasConcept C2776925932 @default.
- W4292061346 hasConcept C2779134260 @default.
- W4292061346 hasConcept C2780924926 @default.
- W4292061346 hasConcept C2780938664 @default.
- W4292061346 hasConcept C31695470 @default.
- W4292061346 hasConcept C43310041 @default.
- W4292061346 hasConcept C513476851 @default.
- W4292061346 hasConcept C529278444 @default.
- W4292061346 hasConcept C552161191 @default.
- W4292061346 hasConcept C55493867 @default.
- W4292061346 hasConcept C71924100 @default.
- W4292061346 hasConcept C86803240 @default.
- W4292061346 hasConcept C95444343 @default.
- W4292061346 hasConceptScore W4292061346C104317684 @default.
- W4292061346 hasConceptScore W4292061346C107459253 @default.
- W4292061346 hasConceptScore W4292061346C126322002 @default.