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- W4292086930 endingPage "111931" @default.
- W4292086930 startingPage "111931" @default.
- W4292086930 abstract "Sarcopenia is a progressive skeletal muscle disease that occurs most commonly in the elderly population, contributing to increased costs and hospitalization. Exercise and nutritional therapy have been proven to be effective for sarcopenia, and some drugs can also alleviate declines in muscle mass and function due to sarcopenia. However, there is no specific pharmacological treatment for sarcopenia at present. This review will mainly discuss the relationship between inflammaging and sarcopenia. The increased secretion of proinflammatory cytokines with aging may be because of cellular senescence, immunosenescence, alterations in adipose tissue, damage-associated molecular patterns (DAMPs), and gut microbes due to aging. These sources of inflammaging can impact the sarcopenia process through direct or indirect pathways. Conversely, sarcopenia can also aggravate the process of inflammaging, creating a vicious cycle. Targeting sources of inflammaging can influence muscle function, which could be considered a therapeutic target for sarcopenia. Moreover, not only proinflammatory cytokines but also anti-inflammatory cytokines can influence muscle and inflammation and participate in the progression of sarcopenia. This review focuses on the effects of TNF-α, IL-6, and IL-10, which can be detected in plasma. Therefore, clearing chronic inflammation by targeting proinflammatory cytokines (TNF-α, IL-1, IL-6) and the inflammatory pathway (JAK/STAT, autophagy, NF-κB) may be effective in treating sarcopenia." @default.
- W4292086930 created "2022-08-17" @default.
- W4292086930 creator A5016644771 @default.
- W4292086930 creator A5022644052 @default.
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- W4292086930 creator A5065379006 @default.
- W4292086930 creator A5085763331 @default.
- W4292086930 creator A5086602956 @default.
- W4292086930 date "2022-10-01" @default.
- W4292086930 modified "2023-10-04" @default.
- W4292086930 title "Inflammaging: The ground for sarcopenia?" @default.
- W4292086930 cites W1481432786 @default.
- W4292086930 cites W1482873758 @default.
- W4292086930 cites W1548049538 @default.
- W4292086930 cites W1819309358 @default.
- W4292086930 cites W1851301093 @default.
- W4292086930 cites W1910950086 @default.
- W4292086930 cites W1918323552 @default.
- W4292086930 cites W1932046626 @default.
- W4292086930 cites W1935296231 @default.
- W4292086930 cites W1968730445 @default.
- W4292086930 cites W1980927217 @default.
- W4292086930 cites W1981109681 @default.
- W4292086930 cites W1982763980 @default.
- W4292086930 cites W1986061293 @default.
- W4292086930 cites W1990069955 @default.
- W4292086930 cites W1992723640 @default.
- W4292086930 cites W1994899697 @default.
- W4292086930 cites W1997105134 @default.
- W4292086930 cites W1997766255 @default.
- W4292086930 cites W1999298001 @default.
- W4292086930 cites W2004314923 @default.
- W4292086930 cites W2005822229 @default.
- W4292086930 cites W2007194743 @default.
- W4292086930 cites W2009111055 @default.
- W4292086930 cites W2009987429 @default.
- W4292086930 cites W2010124801 @default.
- W4292086930 cites W2010911569 @default.
- W4292086930 cites W2012178564 @default.
- W4292086930 cites W2015535527 @default.
- W4292086930 cites W2017075649 @default.
- W4292086930 cites W2018387223 @default.
- W4292086930 cites W2024324546 @default.
- W4292086930 cites W2026185164 @default.
- W4292086930 cites W2027042725 @default.
- W4292086930 cites W2028536701 @default.
- W4292086930 cites W2032691826 @default.
- W4292086930 cites W2033124959 @default.
- W4292086930 cites W2042767581 @default.
- W4292086930 cites W2044838269 @default.
- W4292086930 cites W2045159219 @default.
- W4292086930 cites W204546040 @default.
- W4292086930 cites W2046119060 @default.
- W4292086930 cites W2048549581 @default.
- W4292086930 cites W2050315287 @default.
- W4292086930 cites W2051020804 @default.
- W4292086930 cites W2057597513 @default.
- W4292086930 cites W2058299309 @default.
- W4292086930 cites W2058902172 @default.
- W4292086930 cites W2060129186 @default.
- W4292086930 cites W2064871936 @default.
- W4292086930 cites W2069040857 @default.
- W4292086930 cites W2069519394 @default.
- W4292086930 cites W2070242442 @default.
- W4292086930 cites W2071368241 @default.
- W4292086930 cites W2081067390 @default.
- W4292086930 cites W2082402714 @default.
- W4292086930 cites W2092068607 @default.
- W4292086930 cites W2092943609 @default.
- W4292086930 cites W2094273070 @default.
- W4292086930 cites W2097689258 @default.
- W4292086930 cites W2102330096 @default.
- W4292086930 cites W2104069717 @default.
- W4292086930 cites W2104154119 @default.
- W4292086930 cites W2106248075 @default.
- W4292086930 cites W2110630581 @default.
- W4292086930 cites W2111842746 @default.
- W4292086930 cites W2112914472 @default.
- W4292086930 cites W2113010696 @default.
- W4292086930 cites W2115852450 @default.
- W4292086930 cites W2117457995 @default.
- W4292086930 cites W2120679720 @default.
- W4292086930 cites W2125253058 @default.
- W4292086930 cites W2126407437 @default.
- W4292086930 cites W2128807350 @default.
- W4292086930 cites W2129155846 @default.
- W4292086930 cites W2129976097 @default.
- W4292086930 cites W2131250713 @default.
- W4292086930 cites W2132416790 @default.
- W4292086930 cites W2138673784 @default.
- W4292086930 cites W2140323371 @default.
- W4292086930 cites W2141189887 @default.
- W4292086930 cites W2145336165 @default.
- W4292086930 cites W2146957741 @default.
- W4292086930 cites W2153328565 @default.
- W4292086930 cites W2154753838 @default.
- W4292086930 cites W2156185764 @default.