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• W4292109502 abstract "MicroRNAs (miRNAs) can be used as biomarkers for the diagnosis and therapy of cancers. However, their low abundance and the complex environment in biological samples hinder miRNA detection. A dual amplification strategy based on the bio-barcode technique (BCA) and auto-cycling primer extension (APE) is proposed to detect miRNA targets in complex biological samples. The strategy shows a good sensitivity for miRNA-19a with a detection limit of 50 fM, and can effectively distinguish other similar miRNAs. It provides a new idea to combine nanoparticle-based amplification with nucleic acid-based amplification together for the sensitive detection of nucleic acid targets." @default.
• W4292109502 created "2022-08-17" @default.
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• W4292109502 date "2022-01-01" @default.
• W4292109502 modified "2023-10-18" @default.
• W4292109502 title "Dual amplification of a bio-barcode and auto-cycling primer extension for highly sensitive detection of miRNA" @default.
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• W4292109502 doi "https://doi.org/10.1039/d2cc03864a" @default.
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