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• W4292111572 endingPage "3349.e9" @default.
• W4292111572 startingPage "3333" @default.
• W4292111572 abstract "The interaction of RB with chromatin is key to understanding its molecular functions. Here, for first time, we identify the full spectrum of chromatin-bound RB. Rather than exclusively binding promoters, as is often described, RB targets three fundamentally different types of loci (promoters, enhancers, and insulators), which are largely distinguishable by the mutually exclusive presence of E2F1, c-Jun, and CTCF. While E2F/DP facilitates RB association with promoters, AP-1 recruits RB to enhancers. Although phosphorylation in CDK sites is often portrayed as releasing RB from chromatin, we show that the cell cycle redistributes RB so that it enriches at promoters in G1 and at non-promoter sites in cycling cells. RB-bound promoters include the classic E2F-targets and are similar between lineages, but RB-bound enhancers associate with different categories of genes and vary between cell types. Thus, RB has a well-preserved role controlling E2F in G1, and it targets cell-type-specific enhancers and CTCF sites when cells enter S-phase." @default.
• W4292111572 created "2022-08-17" @default.
• W4292111572 creator A5003016467 @default.
• W4292111572 creator A5003299608 @default.
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• W4292111572 creator A5030510204 @default.
• W4292111572 creator A5033765545 @default.
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• W4292111572 creator A5053906495 @default.
• W4292111572 creator A5054890414 @default.
• W4292111572 creator A5065734287 @default.
• W4292111572 creator A5068897184 @default.
• W4292111572 creator A5070808897 @default.
• W4292111572 creator A5077262131 @default.
• W4292111572 creator A5080386959 @default.
• W4292111572 creator A5085219735 @default.
• W4292111572 date "2022-09-01" @default.
• W4292111572 modified "2023-10-17" @default.
• W4292111572 title "Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression" @default.
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