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- W4292116798 abstract "Evolutionary responses to selection for bipedalism and childbirth have shaped the human pelvis, a structure that differs substantially from that in apes. Morphology related to these factors is present by birth, yet the developmental-genetic mechanisms governing pelvic shape remain largely unknown. Here, we pinpoint and characterize a key gestational window when human-specific pelvic morphology becomes recognizable, as the ilium and the entire pelvis acquire traits essential for human walking and birth. We next use functional genomics to molecularly characterize chondrocytes from different pelvic subelements during this window to reveal their developmental-genetic architectures. We then find notable evidence of ancient selection and genetic constraint on regulatory sequences involved in ilium expansion and growth, findings complemented by our phenotypic analyses showing that variation in iliac traits is reduced in humans compared to African apes. Our datasets provide important resources for musculoskeletal biology and begin to elucidate developmental mechanisms that shape human-specific morphology." @default.
- W4292116798 created "2022-08-17" @default.
- W4292116798 creator A5000174299 @default.
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- W4292116798 date "2022-08-19" @default.
- W4292116798 modified "2023-10-05" @default.
- W4292116798 title "The developmental impacts of natural selection on human pelvic morphology" @default.
- W4292116798 cites W1531821806 @default.
- W4292116798 cites W168428294 @default.
- W4292116798 cites W1710767469 @default.
- W4292116798 cites W1844405070 @default.
- W4292116798 cites W1863440143 @default.
- W4292116798 cites W1898358176 @default.
- W4292116798 cites W1965381574 @default.
- W4292116798 cites W1966235445 @default.
- W4292116798 cites W1967798441 @default.
- W4292116798 cites W1972737244 @default.
- W4292116798 cites W1974073999 @default.
- W4292116798 cites W1974259877 @default.
- W4292116798 cites W1977294183 @default.
- W4292116798 cites W1979594866 @default.
- W4292116798 cites W1980135592 @default.
- W4292116798 cites W1983954594 @default.
- W4292116798 cites W1984058833 @default.
- W4292116798 cites W1985901090 @default.
- W4292116798 cites W1985938067 @default.
- W4292116798 cites W1988187761 @default.
- W4292116798 cites W1990084401 @default.
- W4292116798 cites W1991036278 @default.
- W4292116798 cites W1994079691 @default.
- W4292116798 cites W1998875247 @default.
- W4292116798 cites W1999574084 @default.
- W4292116798 cites W2000672459 @default.
- W4292116798 cites W2004116172 @default.
- W4292116798 cites W2006244621 @default.
- W4292116798 cites W2011498576 @default.
- W4292116798 cites W2014677321 @default.
- W4292116798 cites W2016144053 @default.
- W4292116798 cites W2024439539 @default.
- W4292116798 cites W2025046506 @default.
- W4292116798 cites W2029069149 @default.
- W4292116798 cites W2030993345 @default.
- W4292116798 cites W2035618305 @default.
- W4292116798 cites W2036582407 @default.
- W4292116798 cites W2039863382 @default.
- W4292116798 cites W2044375333 @default.
- W4292116798 cites W2044413297 @default.
- W4292116798 cites W2045099631 @default.
- W4292116798 cites W2047244839 @default.
- W4292116798 cites W2050962411 @default.
- W4292116798 cites W2068162513 @default.
- W4292116798 cites W2073418703 @default.
- W4292116798 cites W2075764651 @default.
- W4292116798 cites W2079615941 @default.
- W4292116798 cites W2079733708 @default.
- W4292116798 cites W2082704080 @default.
- W4292116798 cites W2085384621 @default.
- W4292116798 cites W2089291742 @default.
- W4292116798 cites W2094820244 @default.
- W4292116798 cites W2094926899 @default.
- W4292116798 cites W2097856972 @default.
- W4292116798 cites W2098573707 @default.
- W4292116798 cites W2098885981 @default.
- W4292116798 cites W2100847604 @default.
- W4292116798 cites W2102619694 @default.
- W4292116798 cites W2104549677 @default.
- W4292116798 cites W2113818851 @default.
- W4292116798 cites W2114794895 @default.
- W4292116798 cites W2116591973 @default.
- W4292116798 cites W2117757143 @default.
- W4292116798 cites W2123257600 @default.
- W4292116798 cites W2123511429 @default.
- W4292116798 cites W2124799197 @default.
- W4292116798 cites W2125751059 @default.
- W4292116798 cites W2127608175 @default.
- W4292116798 cites W2128016314 @default.
- W4292116798 cites W2131234958 @default.
- W4292116798 cites W2131776976 @default.
- W4292116798 cites W2133663604 @default.
- W4292116798 cites W2135144225 @default.
- W4292116798 cites W2137706757 @default.
- W4292116798 cites W2142386149 @default.
- W4292116798 cites W2145521965 @default.
- W4292116798 cites W2146511318 @default.
- W4292116798 cites W2149992227 @default.
- W4292116798 cites W2150131459 @default.
- W4292116798 cites W2152124541 @default.
- W4292116798 cites W2152509610 @default.
- W4292116798 cites W2154862494 @default.