Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292117596> ?p ?o ?g. }
- W4292117596 abstract "Abstract The cerebrospinal fluid (CSF) features a unique immune cell composition and is in constant contact with the brain borders, thus permitting insights into the brain to diagnose and monitor diseases. Recently, the meninges, which are filled with CSF, were identified as a neuroimmunological interface, highlighting the potential of exploring central nervous system (CNS) immunity by studying CNS border compartments. Here, we summarize how single-cell transcriptomics of such border compartments advance our understanding of neurological diseases, the challenges that remain, and what opportunities novel multi-omic methods offer. Single-cell transcriptomics studies have detected cytotoxic CD4 + T cells and clonally expanded T and B cells in the CSF in the autoimmune disease multiple sclerosis; clonally expanded pathogenic CD8 + T cells were found in the CSF and in the brain adjacent to β-amyloid plaques of dementia patients; in patients with brain metastases, CD8 + T cell clonotypes were shared between the brain parenchyma and the CSF and persisted after therapy. We also outline how novel multi-omic approaches permit the simultaneous measurements of gene expression, chromatin accessibility, and protein in the same cells, which remain to be explored in the CSF. This calls for multicenter initiatives to create single-cell atlases, posing challenges in integrating patients and modalities across centers. While high-dimensional analyses of CSF cells are challenging, they hold potential for personalized medicine by better resolving heterogeneous diseases and stratifying patients." @default.
- W4292117596 created "2022-08-17" @default.
- W4292117596 creator A5022499856 @default.
- W4292117596 creator A5036834603 @default.
- W4292117596 creator A5037255370 @default.
- W4292117596 creator A5038373894 @default.
- W4292117596 date "2022-08-17" @default.
- W4292117596 modified "2023-09-27" @default.
- W4292117596 title "High-dimensional investigation of the cerebrospinal fluid to explore and monitor CNS immune responses" @default.
- W4292117596 cites W1967327758 @default.
- W4292117596 cites W1990348466 @default.
- W4292117596 cites W1990458250 @default.
- W4292117596 cites W1999952543 @default.
- W4292117596 cites W2013672443 @default.
- W4292117596 cites W2018398431 @default.
- W4292117596 cites W2034860726 @default.
- W4292117596 cites W2043651330 @default.
- W4292117596 cites W2050034605 @default.
- W4292117596 cites W2060279158 @default.
- W4292117596 cites W2070498846 @default.
- W4292117596 cites W2102212449 @default.
- W4292117596 cites W2128948123 @default.
- W4292117596 cites W2129719133 @default.
- W4292117596 cites W2135937351 @default.
- W4292117596 cites W2148898943 @default.
- W4292117596 cites W2155373800 @default.
- W4292117596 cites W2167183660 @default.
- W4292117596 cites W2167765715 @default.
- W4292117596 cites W2506326107 @default.
- W4292117596 cites W2535103378 @default.
- W4292117596 cites W2545155109 @default.
- W4292117596 cites W2591646072 @default.
- W4292117596 cites W2626252716 @default.
- W4292117596 cites W2739492614 @default.
- W4292117596 cites W2743416243 @default.
- W4292117596 cites W2746479894 @default.
- W4292117596 cites W2753908609 @default.
- W4292117596 cites W2766128503 @default.
- W4292117596 cites W2774307122 @default.
- W4292117596 cites W2777074421 @default.
- W4292117596 cites W2783929588 @default.
- W4292117596 cites W2785085486 @default.
- W4292117596 cites W2792603152 @default.
- W4292117596 cites W2805197831 @default.
- W4292117596 cites W2889443750 @default.
- W4292117596 cites W2890506734 @default.
- W4292117596 cites W2892318814 @default.
- W4292117596 cites W2901677030 @default.
- W4292117596 cites W2904800311 @default.
- W4292117596 cites W2908002252 @default.
- W4292117596 cites W2911822431 @default.
- W4292117596 cites W2916020270 @default.
- W4292117596 cites W2949177718 @default.
- W4292117596 cites W2949829455 @default.
- W4292117596 cites W2951560273 @default.
- W4292117596 cites W2964087368 @default.
- W4292117596 cites W2965985232 @default.
- W4292117596 cites W2977543492 @default.
- W4292117596 cites W2979911343 @default.
- W4292117596 cites W2984472267 @default.
- W4292117596 cites W2995043840 @default.
- W4292117596 cites W2999689705 @default.
- W4292117596 cites W3000319248 @default.
- W4292117596 cites W3002417351 @default.
- W4292117596 cites W3009365272 @default.
- W4292117596 cites W3018373832 @default.
- W4292117596 cites W3023941798 @default.
- W4292117596 cites W3043398874 @default.
- W4292117596 cites W3082437287 @default.
- W4292117596 cites W3087245118 @default.
- W4292117596 cites W3093858607 @default.
- W4292117596 cites W3095091383 @default.
- W4292117596 cites W3111799671 @default.
- W4292117596 cites W3114322636 @default.
- W4292117596 cites W3119858057 @default.
- W4292117596 cites W3120391035 @default.
- W4292117596 cites W3125308054 @default.
- W4292117596 cites W3125753820 @default.
- W4292117596 cites W3131957723 @default.
- W4292117596 cites W3135605575 @default.
- W4292117596 cites W3153691873 @default.
- W4292117596 cites W3157834780 @default.
- W4292117596 cites W3159116119 @default.
- W4292117596 cites W3159288344 @default.
- W4292117596 cites W3160973971 @default.
- W4292117596 cites W3164692211 @default.
- W4292117596 cites W3164839005 @default.
- W4292117596 cites W3164896384 @default.
- W4292117596 cites W3165520347 @default.
- W4292117596 cites W3165815938 @default.
- W4292117596 cites W3179549473 @default.
- W4292117596 cites W3180646261 @default.
- W4292117596 cites W3194301212 @default.
- W4292117596 cites W3196356589 @default.
- W4292117596 cites W3202201575 @default.
- W4292117596 cites W3202649987 @default.
- W4292117596 cites W3205323262 @default.
- W4292117596 cites W3209238322 @default.
- W4292117596 cites W3212064262 @default.
- W4292117596 cites W3215551486 @default.