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• W4292121883 abstract "Abstract Clinical decision support systems based on machine-learning algorithms are largely applied in the context of the diagnosis of neurodegenerative diseases (NDDs). While recent models yield robust classifications in supervised two classes-problems accurately separating Parkinson’s disease (PD) from healthy control (HC) subjects, few works looked at prodromal stages of NDDs. Idiopathic Rapid-eye Movement (REM) sleep behavior disorder (iRBD) is considered a prodromal stage of PD with a high chance of phenoconversion but with heterogeneous symptoms that hinder accurate disease prediction. Machine learning (ML) based methods can be used to develop personalized trajectory models, but these require large amounts of observational points with homogenous features significantly reducing the possible imaging modalities to non-invasive and cost-effective techniques such as high-density electrophysiology (hdEEG). In this work, we aimed at quantifying the increase in accuracy and robustness of the classification model with the inclusion of network-based metrics compared to the classical Fourier-based power spectral density (PSD). We performed a series of analyses to quantify significance in cohort-wise metrics, the performance of classification tasks, and the effect of feature selection on model accuracy. We report that amplitude correlation spectral profiles show the largest difference between iRBD and HC subjects mainly in delta and theta bands. Moreover, the inclusion of amplitude correlation and phase synchronization improves the classification performance by up to 11% compared to using PSD alone. Our results show that hdEEG features alone can be used as potential biomarkers in classification problems using iRBD data and that large-scale network metrics improve the performance of the model. This evidence suggests that large-scale brain network metrics should be considered important tools for investigating prodromal stages of NDD as they yield more information without harming the patient, allowing for constant and frequent longitudinal evaluation of patients at high risk of phenoconversion. Highlights Network-based features are important tools to investigate prodromal stages of PD Amplitude correlation shows the largest difference between two groups in 9/30 bands Amplitude correlation improved up to 11% the performance compared to PSD alone Classification robustness increases when we use both network-based EEG features Classifier performance worsens when PSD is added to network-based EEG features" @default.
• W4292121883 created "2022-08-17" @default.
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• W4292121883 date "2022-08-17" @default.
• W4292121883 modified "2023-10-18" @default.
• W4292121883 title "Large-scale network metrics improve the classification performance of rapid-eye-movement sleep behavior disorder patients" @default.
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• W4292121883 doi "https://doi.org/10.1101/2022.08.16.504129" @default.
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