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- W4292155258 abstract "Abstract Glucose is regarded as a clinical biomarker, and the abnormal level of glucose in blood would cause endocrine metabolic diseases. Thus, it is of great significance to develop a simple, accurate, and sensitive method for glucose detection. In this work, we synthesized an iron porphyrin-based porous organic framework (Fe-POF) through a facile alkylation reaction between 5,10,15,20-tetra(4-aminophenyl) porphyrin (TAPP) and cyanuric chloride. Fe-POF exhibited excellent peroxidase-like activity and could be used to detect hydrogen peroxide and the molecules associated with hydrogen peroxide such as glucose. The structure of Fe-POF was confirmed through a series of methods, such as FT-IR, SEM, EDS, TEM, and XPS. Fe-POF exhibited excellent peroxidase-like activity, which could catalyze the oxidization of colorless 3,3′,5,5′-tetramethylbenzidine (TMB) into blue product (ox-TMB) in the presence of hydrogen peroxide (H 2 O 2 ). Based on this phenomenon, a simple colorimetric assay was constructed for the detection of H 2 O 2 and glucose with high selectivity and sensitivity. The detection limit of H 2 O 2 and glucose was calculated to be 1.8 and 1.39 µM, respectively. Finally, Fe-POF was applied as a colorimetric sensor for rapid detection of glucose in diluted serum samples." @default.
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- W4292155258 date "2022-08-17" @default.
- W4292155258 modified "2023-10-16" @default.
- W4292155258 title "Porphyrin-based porous organic frameworks as efficient peroxidase mimics for selective detection of hydrogen peroxide and glucose" @default.
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- W4292155258 doi "https://doi.org/10.21203/rs.3.rs-1951269/v1" @default.
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