Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292161105> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4292161105 endingPage "68" @default.
- W4292161105 startingPage "62" @default.
- W4292161105 abstract "Nicorandil, an adenosine triphosphate-sensitive potassium channel agonist and nitric oxide donor, is a coronary vasodilator used to treat ischemia-induced chest pain, but it's potential cardioprotective benefits during open heart surgery have not been thoroughly investigated. The study objective was to assess the impact of nicorandil on postoperative ventricular dysfunction and end-organ injury in an established experimental model of open-heart surgery with cardiopulmonary bypass (CPB) and cardioplegic arrest. We hypothesized that nicorandil would attenuate myocardial ischemia-reperfusion (IR) injury, preserve ventricular function, and reduce end-organ injury.Rabbits were cannulated for CPB, followed by 60 min of aortic cross-clamp (ACC) with cold cardioplegic arrest, and 120 min of recovery after ACC removal. Nicorandil (or normal saline vehicle) was given intravenously 5 min before ACC and continued throughout the recovery period. Left ventricular developed pressure (LVDP), systolic contractility (LV + dP/dt), and diastolic relaxation (LV -dP/dt) were continuously recorded, and blood and tissue samples were collected for measurement of oxidant stress (OS), inflammation, apoptosis, and organ injury.Nicorandil significantly attenuated IR-induced LV dysfunction compared to saline control (R-120: LV + dP/dt: 1596 ± 397 vs. 514 ± 269 mmHg/s, p = 0.010; LV -dP/dt: -1524 ± 432 vs. -432 ± 243 mmHg/s, p < 0.001; LVDP: 55 ± 11 vs. 22 ± 5 mmHg, p = 0.046). Furthermore, nicorandil inhibited IR-induced increases in OS, inflammation, apoptosis, and organ injury.Nicorandil exhibits myocardial protection by attenuation of IR-induced LV dysfunction associated with OS, inflammation, apoptosis, and organ injury. Nicorandil should be explored further as a potential therapeutic strategy for limiting global IR injury during open-heart surgery in humans." @default.
- W4292161105 created "2022-08-18" @default.
- W4292161105 creator A5000880099 @default.
- W4292161105 creator A5034009146 @default.
- W4292161105 creator A5049019507 @default.
- W4292161105 creator A5067100829 @default.
- W4292161105 creator A5068161609 @default.
- W4292161105 creator A5071859357 @default.
- W4292161105 date "2022-12-01" @default.
- W4292161105 modified "2023-09-27" @default.
- W4292161105 title "Nicorandil attenuates ventricular dysfunction and organ injury after cardiopulmonary bypass" @default.
- W4292161105 cites W1995066360 @default.
- W4292161105 cites W2017575446 @default.
- W4292161105 cites W2028349892 @default.
- W4292161105 cites W2057030522 @default.
- W4292161105 cites W2058429814 @default.
- W4292161105 cites W2078538563 @default.
- W4292161105 cites W2082085102 @default.
- W4292161105 cites W2092248444 @default.
- W4292161105 cites W2092986320 @default.
- W4292161105 cites W2100942696 @default.
- W4292161105 cites W2146063823 @default.
- W4292161105 cites W2162035909 @default.
- W4292161105 cites W2167411351 @default.
- W4292161105 cites W2265407141 @default.
- W4292161105 cites W2314468100 @default.
- W4292161105 cites W2319823306 @default.
- W4292161105 cites W2320154940 @default.
- W4292161105 cites W2326462041 @default.
- W4292161105 cites W2442275783 @default.
- W4292161105 cites W2517669870 @default.
- W4292161105 cites W2592937558 @default.
- W4292161105 cites W2691152356 @default.
- W4292161105 cites W2888581472 @default.
- W4292161105 cites W2894193525 @default.
- W4292161105 cites W2990362896 @default.
- W4292161105 cites W3116280803 @default.
- W4292161105 doi "https://doi.org/10.1016/j.ijcard.2022.08.030" @default.
- W4292161105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35987313" @default.
- W4292161105 hasPublicationYear "2022" @default.
- W4292161105 type Work @default.
- W4292161105 citedByCount "3" @default.
- W4292161105 countsByYear W42921611052023 @default.
- W4292161105 crossrefType "journal-article" @default.
- W4292161105 hasAuthorship W4292161105A5000880099 @default.
- W4292161105 hasAuthorship W4292161105A5034009146 @default.
- W4292161105 hasAuthorship W4292161105A5049019507 @default.
- W4292161105 hasAuthorship W4292161105A5067100829 @default.
- W4292161105 hasAuthorship W4292161105A5068161609 @default.
- W4292161105 hasAuthorship W4292161105A5071859357 @default.
- W4292161105 hasConcept C126322002 @default.
- W4292161105 hasConcept C164705383 @default.
- W4292161105 hasConcept C2777194220 @default.
- W4292161105 hasConcept C2778384902 @default.
- W4292161105 hasConcept C2778426790 @default.
- W4292161105 hasConcept C2778881276 @default.
- W4292161105 hasConcept C2778902376 @default.
- W4292161105 hasConcept C2780114680 @default.
- W4292161105 hasConcept C39133596 @default.
- W4292161105 hasConcept C42219234 @default.
- W4292161105 hasConcept C541997718 @default.
- W4292161105 hasConcept C71924100 @default.
- W4292161105 hasConcept C83743174 @default.
- W4292161105 hasConceptScore W4292161105C126322002 @default.
- W4292161105 hasConceptScore W4292161105C164705383 @default.
- W4292161105 hasConceptScore W4292161105C2777194220 @default.
- W4292161105 hasConceptScore W4292161105C2778384902 @default.
- W4292161105 hasConceptScore W4292161105C2778426790 @default.
- W4292161105 hasConceptScore W4292161105C2778881276 @default.
- W4292161105 hasConceptScore W4292161105C2778902376 @default.
- W4292161105 hasConceptScore W4292161105C2780114680 @default.
- W4292161105 hasConceptScore W4292161105C39133596 @default.
- W4292161105 hasConceptScore W4292161105C42219234 @default.
- W4292161105 hasConceptScore W4292161105C541997718 @default.
- W4292161105 hasConceptScore W4292161105C71924100 @default.
- W4292161105 hasConceptScore W4292161105C83743174 @default.
- W4292161105 hasFunder F4320332682 @default.
- W4292161105 hasLocation W42921611051 @default.
- W4292161105 hasLocation W42921611052 @default.
- W4292161105 hasOpenAccess W4292161105 @default.
- W4292161105 hasPrimaryLocation W42921611051 @default.
- W4292161105 hasRelatedWork W1985250688 @default.
- W4292161105 hasRelatedWork W2040976499 @default.
- W4292161105 hasRelatedWork W2094302753 @default.
- W4292161105 hasRelatedWork W2159512267 @default.
- W4292161105 hasRelatedWork W2162443708 @default.
- W4292161105 hasRelatedWork W3145154383 @default.
- W4292161105 hasRelatedWork W3182617902 @default.
- W4292161105 hasRelatedWork W4221039190 @default.
- W4292161105 hasRelatedWork W4292161105 @default.
- W4292161105 hasRelatedWork W2030443007 @default.
- W4292161105 hasVolume "368" @default.
- W4292161105 isParatext "false" @default.
- W4292161105 isRetracted "false" @default.
- W4292161105 workType "article" @default.