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- W4292170332 abstract "A whole-cell model represents certain aspects of the cell structure and/or function. Due to the high complexity of the cell, an integrative modeling approach is often taken to utilize all available information including experimental data, prior knowledge and prior models. In this review, we summarize an emerging workflow of whole-cell modeling into five steps: (i) gather information; (ii) represent the modeled system into modules; (iii) translate input information into scoring function; (iv) sample the whole-cell model; (v) validate and interpret the model. In particular, we propose the integrative modeling of the cell by combining available (whole-cell) models to maximize the accuracy, precision, and completeness. In addition, we list quantitative predictions of various aspects of cell biology from existing whole-cell models. Moreover, we discuss the remaining challenges and future directions, and highlight the opportunity to establish an integrative spatiotemporal multi-scale whole-cell model based on a community approach." @default.
- W4292170332 created "2022-08-18" @default.
- W4292170332 creator A5024375259 @default.
- W4292170332 creator A5030978002 @default.
- W4292170332 creator A5036552515 @default.
- W4292170332 date "2022-08-01" @default.
- W4292170332 modified "2023-09-23" @default.
- W4292170332 title "Integrative modeling of the cell" @default.
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