Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292182213> ?p ?o ?g. }
- W4292182213 endingPage "111195" @default.
- W4292182213 startingPage "111195" @default.
- W4292182213 abstract "ATG9A is a highly conserved membrane protein required for autophagy initiation. It is trafficked from the trans-Golgi network (TGN) to the phagophore to act as a membrane source for autophagosome expansion. Here, we show that ATG9A is not just a passenger protein in the TGN but rather works in concert with GRASP55, a stacking factor for Golgi structure, to organize Golgi dynamics and integrity. Upon heat stress, the E3 ubiquitin ligase MARCH9 is promoted to ubiquitinate ATG9A in the form of K63 conjugation, and the nondegradable ubiquitinated ATG9A disperses from the Golgi apparatus to the cytoplasm more intensely, accompanied by inhibiting GRASP55 oligomerization, further resulting in Golgi fragmentation. Knockout of ATG9A or MARCH9 largely prevents Golgi fragmentation and protects Golgi functions under heat and other Golgi stresses. Our results reveal a noncanonical function of ATG9A for Golgi dynamics and suggest the pathway for sensing Golgi stress via the MARCH9/ATG9A axis." @default.
- W4292182213 created "2022-08-18" @default.
- W4292182213 creator A5002112715 @default.
- W4292182213 creator A5014068004 @default.
- W4292182213 creator A5030290401 @default.
- W4292182213 creator A5033510051 @default.
- W4292182213 creator A5035385255 @default.
- W4292182213 creator A5036264996 @default.
- W4292182213 creator A5037258424 @default.
- W4292182213 creator A5037998825 @default.
- W4292182213 creator A5039933653 @default.
- W4292182213 creator A5044832847 @default.
- W4292182213 creator A5050751602 @default.
- W4292182213 creator A5053080396 @default.
- W4292182213 creator A5067120641 @default.
- W4292182213 creator A5067930787 @default.
- W4292182213 creator A5072214656 @default.
- W4292182213 creator A5073868509 @default.
- W4292182213 creator A5079868220 @default.
- W4292182213 date "2022-08-01" @default.
- W4292182213 modified "2023-10-13" @default.
- W4292182213 title "Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses" @default.
- W4292182213 cites W1596180649 @default.
- W4292182213 cites W1971170718 @default.
- W4292182213 cites W1984847156 @default.
- W4292182213 cites W1994423882 @default.
- W4292182213 cites W2000418155 @default.
- W4292182213 cites W2027418077 @default.
- W4292182213 cites W2032186831 @default.
- W4292182213 cites W2043540325 @default.
- W4292182213 cites W2051881782 @default.
- W4292182213 cites W2054783408 @default.
- W4292182213 cites W2077426741 @default.
- W4292182213 cites W2082278337 @default.
- W4292182213 cites W2104076764 @default.
- W4292182213 cites W2107426425 @default.
- W4292182213 cites W2109167860 @default.
- W4292182213 cites W2136773542 @default.
- W4292182213 cites W2140857516 @default.
- W4292182213 cites W2141711186 @default.
- W4292182213 cites W2147966944 @default.
- W4292182213 cites W2150168624 @default.
- W4292182213 cites W2150398921 @default.
- W4292182213 cites W2159282837 @default.
- W4292182213 cites W2161895799 @default.
- W4292182213 cites W2167452849 @default.
- W4292182213 cites W2217094724 @default.
- W4292182213 cites W2288642608 @default.
- W4292182213 cites W2318418872 @default.
- W4292182213 cites W2473679261 @default.
- W4292182213 cites W2560394908 @default.
- W4292182213 cites W2587294116 @default.
- W4292182213 cites W2604489667 @default.
- W4292182213 cites W2746372947 @default.
- W4292182213 cites W2768173030 @default.
- W4292182213 cites W2785733620 @default.
- W4292182213 cites W2799285454 @default.
- W4292182213 cites W2904801161 @default.
- W4292182213 cites W2933225319 @default.
- W4292182213 cites W2990272651 @default.
- W4292182213 cites W2991621157 @default.
- W4292182213 cites W3002600101 @default.
- W4292182213 cites W3011930227 @default.
- W4292182213 cites W3038998766 @default.
- W4292182213 cites W3083133776 @default.
- W4292182213 cites W3093507769 @default.
- W4292182213 cites W3110804826 @default.
- W4292182213 cites W3115150918 @default.
- W4292182213 cites W3174221495 @default.
- W4292182213 cites W3177552861 @default.
- W4292182213 cites W3178542355 @default.
- W4292182213 cites W3212049905 @default.
- W4292182213 cites W4212806212 @default.
- W4292182213 cites W4214662482 @default.
- W4292182213 doi "https://doi.org/10.1016/j.celrep.2022.111195" @default.
- W4292182213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35977480" @default.
- W4292182213 hasPublicationYear "2022" @default.
- W4292182213 type Work @default.
- W4292182213 citedByCount "5" @default.
- W4292182213 countsByYear W42921822132022 @default.
- W4292182213 countsByYear W42921822132023 @default.
- W4292182213 crossrefType "journal-article" @default.
- W4292182213 hasAuthorship W4292182213A5002112715 @default.
- W4292182213 hasAuthorship W4292182213A5014068004 @default.
- W4292182213 hasAuthorship W4292182213A5030290401 @default.
- W4292182213 hasAuthorship W4292182213A5033510051 @default.
- W4292182213 hasAuthorship W4292182213A5035385255 @default.
- W4292182213 hasAuthorship W4292182213A5036264996 @default.
- W4292182213 hasAuthorship W4292182213A5037258424 @default.
- W4292182213 hasAuthorship W4292182213A5037998825 @default.
- W4292182213 hasAuthorship W4292182213A5039933653 @default.
- W4292182213 hasAuthorship W4292182213A5044832847 @default.
- W4292182213 hasAuthorship W4292182213A5050751602 @default.
- W4292182213 hasAuthorship W4292182213A5053080396 @default.
- W4292182213 hasAuthorship W4292182213A5067120641 @default.
- W4292182213 hasAuthorship W4292182213A5067930787 @default.
- W4292182213 hasAuthorship W4292182213A5072214656 @default.
- W4292182213 hasAuthorship W4292182213A5073868509 @default.