Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292183618> ?p ?o ?g. }
- W4292183618 abstract "How the glioma immune microenvironment fosters tumorigenesis remains incompletely defined. Here, we use single-cell RNA-sequencing and multiplexed tissue-imaging to characterize the composition, spatial organization, and clinical significance of extracellular purinergic signaling in glioma. We show that microglia are the predominant source of CD39, while tumor cells principally express CD73. In glioblastoma, CD73 is associated with EGFR amplification, astrocyte-like differentiation, and increased adenosine, and is linked to hypoxia. Glioblastomas enriched for CD73 exhibit inflammatory microenvironments, suggesting that purinergic signaling regulates immune adaptation. Spatially-resolved single-cell analyses demonstrate a strong spatial correlation between tumor-CD73 and microglial-CD39, with proximity associated with poor outcomes. Similar spatial organization is present in pediatric high-grade gliomas including H3K27M-mutant diffuse midline glioma. These data reveal that purinergic signaling in gliomas is shaped by genotype, lineage, and functional state, and that core enzymes expressed by tumor and myeloid cells are organized to promote adenosine-rich microenvironments potentially amenable to therapeutic targeting." @default.
- W4292183618 created "2022-08-18" @default.
- W4292183618 creator A5005796905 @default.
- W4292183618 creator A5008511648 @default.
- W4292183618 creator A5010234110 @default.
- W4292183618 creator A5010270402 @default.
- W4292183618 creator A5011894823 @default.
- W4292183618 creator A5012379493 @default.
- W4292183618 creator A5015635179 @default.
- W4292183618 creator A5021656597 @default.
- W4292183618 creator A5039683075 @default.
- W4292183618 creator A5048399682 @default.
- W4292183618 creator A5049217703 @default.
- W4292183618 creator A5053102971 @default.
- W4292183618 creator A5054613619 @default.
- W4292183618 creator A5055282139 @default.
- W4292183618 creator A5056872026 @default.
- W4292183618 creator A5061890301 @default.
- W4292183618 creator A5063426870 @default.
- W4292183618 creator A5068953785 @default.
- W4292183618 creator A5071238782 @default.
- W4292183618 creator A5075621139 @default.
- W4292183618 creator A5078508725 @default.
- W4292183618 creator A5085626192 @default.
- W4292183618 creator A5085973734 @default.
- W4292183618 date "2022-08-16" @default.
- W4292183618 modified "2023-10-16" @default.
- W4292183618 title "Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma" @default.
- W4292183618 cites W1601383153 @default.
- W4292183618 cites W1978435636 @default.
- W4292183618 cites W1986986419 @default.
- W4292183618 cites W2043565262 @default.
- W4292183618 cites W2053129129 @default.
- W4292183618 cites W2055532721 @default.
- W4292183618 cites W2063264144 @default.
- W4292183618 cites W2065854120 @default.
- W4292183618 cites W2078490888 @default.
- W4292183618 cites W2080167283 @default.
- W4292183618 cites W2086556660 @default.
- W4292183618 cites W2096465161 @default.
- W4292183618 cites W2097801564 @default.
- W4292183618 cites W2103017472 @default.
- W4292183618 cites W2110443940 @default.
- W4292183618 cites W2119268142 @default.
- W4292183618 cites W2130410032 @default.
- W4292183618 cites W2153955573 @default.
- W4292183618 cites W2163676912 @default.
- W4292183618 cites W2168786562 @default.
- W4292183618 cites W2170490448 @default.
- W4292183618 cites W2185207072 @default.
- W4292183618 cites W2280077905 @default.
- W4292183618 cites W2292051166 @default.
- W4292183618 cites W2323326409 @default.
- W4292183618 cites W2344591493 @default.
- W4292183618 cites W2406250479 @default.
- W4292183618 cites W2551013093 @default.
- W4292183618 cites W2604591951 @default.
- W4292183618 cites W2626614537 @default.
- W4292183618 cites W2737046088 @default.
- W4292183618 cites W2751187578 @default.
- W4292183618 cites W2758605709 @default.
- W4292183618 cites W2772624269 @default.
- W4292183618 cites W2773314950 @default.
- W4292183618 cites W2790470415 @default.
- W4292183618 cites W2794480084 @default.
- W4292183618 cites W2795989238 @default.
- W4292183618 cites W2797470297 @default.
- W4292183618 cites W2802561340 @default.
- W4292183618 cites W2832881433 @default.
- W4292183618 cites W2898890542 @default.
- W4292183618 cites W2900044275 @default.
- W4292183618 cites W2910026377 @default.
- W4292183618 cites W2911752971 @default.
- W4292183618 cites W2911871569 @default.
- W4292183618 cites W2913623258 @default.
- W4292183618 cites W2917101543 @default.
- W4292183618 cites W2930154557 @default.
- W4292183618 cites W2932122825 @default.
- W4292183618 cites W2949238013 @default.
- W4292183618 cites W2952845679 @default.
- W4292183618 cites W2953801846 @default.
- W4292183618 cites W2961217357 @default.
- W4292183618 cites W2968292465 @default.
- W4292183618 cites W2973401242 @default.
- W4292183618 cites W2973779191 @default.
- W4292183618 cites W2983134909 @default.
- W4292183618 cites W2987759842 @default.
- W4292183618 cites W2995345254 @default.
- W4292183618 cites W3016787828 @default.
- W4292183618 cites W3017270631 @default.
- W4292183618 cites W3020099303 @default.
- W4292183618 cites W3026551532 @default.
- W4292183618 cites W3043335732 @default.
- W4292183618 cites W3046015080 @default.
- W4292183618 cites W3099035428 @default.
- W4292183618 cites W3112600195 @default.
- W4292183618 cites W3120974102 @default.
- W4292183618 cites W3146935595 @default.
- W4292183618 cites W3148551472 @default.
- W4292183618 cites W3150063851 @default.