FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292188253> ?p ?o ?g. }

• W4292188253 abstract "Background Esophagogastric junction adenocarcinoma (EGJA) is a special malignant tumor with unknown biological behavior. PD-1 checkpoint inhibitors have been recommended as first-line treatment for advanced EGJA patients. However, the biomarkers for predicting immunotherapy response remain controversial. Methods We identified stromal immune-related genes (SIRGs) by ESTIMATE from the TCGA-EGJA dataset and constructed a signature score. In addition, survival analysis was performed in both the TCGA cohort and GEO cohort. Subsequently, we explored the differences in tumor-infiltrating immune cells, immune subtypes, immune-related functions, tumor mutation burden (TMB), immune checkpoint gene expression, immunophenoscore (IPS) between the high SIRGs score and low SIRGs score groups. Finally, two validation cohorts of patients who had accepted immunotherapy was used to verify the value of SIRGs score in predicting immunotherapy response. Results Eight of the SIRGs were selected by LASSO regression to construct a signature score (SIRGs score). Univariate and multivariate analyses in the TCGA and GEO cohort suggested that SIRGs score was an independent risk factor for the overall survival (OS) and it could increase the accuracy of clinical prediction models for survival. However, in the high SIRGs score group, patients had more immune cell infiltration, more active immune-related functions, higher immune checkpoint gene expression and higher IPS-PD1 and IPS-PD1-CTLA4 scores, which indicate a better response to immunotherapy. The external validation illustrated that high SIRGs score was significantly associated with immunotherapy response and immune checkpoint inhibitors (ICIs) can improve OS in patients with high SIRGs score. Conclusion The SIRGs score may be a predictor of the prognosis and immune-therapy response for esophagogastric junction adenocarcinoma." @default.
• W4292188253 created "2022-08-18" @default.
• W4292188253 creator A5019879410 @default.
• W4292188253 creator A5021883274 @default.
• W4292188253 creator A5027862454 @default.
• W4292188253 creator A5036262283 @default.
• W4292188253 creator A5036273689 @default.
• W4292188253 creator A5038532452 @default.
• W4292188253 creator A5064931883 @default.
• W4292188253 creator A5069772977 @default.
• W4292188253 creator A5082465884 @default.
• W4292188253 date "2022-08-16" @default.
• W4292188253 modified "2023-10-18" @default.
• W4292188253 title "SIRGs score may be a predictor of prognosis and immunotherapy response for esophagogastric junction adenocarcinoma" @default.
• W4292188253 cites W2004630197 @default.
• W4292188253 cites W2054059601 @default.
• W4292188253 cites W2060469376 @default.
• W4292188253 cites W2074490061 @default.
• W4292188253 cites W2117692326 @default.
• W4292188253 cites W2123879591 @default.
• W4292188253 cites W2130410032 @default.
• W4292188253 cites W2130430382 @default.
• W4292188253 cites W2133414665 @default.
• W4292188253 cites W2143150168 @default.
• W4292188253 cites W2209490988 @default.
• W4292188253 cites W2314057593 @default.
• W4292188253 cites W2334484798 @default.
• W4292188253 cites W2507880739 @default.
• W4292188253 cites W2559382297 @default.
• W4292188253 cites W2559943376 @default.
• W4292188253 cites W2607255551 @default.
• W4292188253 cites W2617251978 @default.
• W4292188253 cites W2765224588 @default.
• W4292188253 cites W2785803176 @default.
• W4292188253 cites W2788142646 @default.
• W4292188253 cites W2794316022 @default.
• W4292188253 cites W2805388317 @default.
• W4292188253 cites W2895441403 @default.
• W4292188253 cites W2899084160 @default.
• W4292188253 cites W2906436263 @default.
• W4292188253 cites W2945790786 @default.
• W4292188253 cites W2949273159 @default.
• W4292188253 cites W2949492942 @default.
• W4292188253 cites W2963122005 @default.
• W4292188253 cites W2983326574 @default.
• W4292188253 cites W3013141357 @default.
• W4292188253 cites W3026261463 @default.
• W4292188253 cites W3029490475 @default.
• W4292188253 cites W3080471106 @default.
• W4292188253 cites W3082736986 @default.
• W4292188253 cites W3085168500 @default.
• W4292188253 cites W3158954350 @default.
• W4292188253 cites W3160196987 @default.
• W4292188253 cites W3171517418 @default.
• W4292188253 cites W3185575089 @default.
• W4292188253 cites W4206449839 @default.
• W4292188253 cites W4226075276 @default.
• W4292188253 cites W4250948394 @default.
• W4292188253 doi "https://doi.org/10.3389/fimmu.2022.977894" @default.
• W4292188253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36052090" @default.
• W4292188253 hasPublicationYear "2022" @default.
• W4292188253 type Work @default.
• W4292188253 citedByCount "0" @default.
• W4292188253 crossrefType "journal-article" @default.
• W4292188253 hasAuthorship W4292188253A5019879410 @default.
• W4292188253 hasAuthorship W4292188253A5021883274 @default.
• W4292188253 hasAuthorship W4292188253A5027862454 @default.
• W4292188253 hasAuthorship W4292188253A5036262283 @default.
• W4292188253 hasAuthorship W4292188253A5036273689 @default.
• W4292188253 hasAuthorship W4292188253A5038532452 @default.
• W4292188253 hasAuthorship W4292188253A5064931883 @default.
• W4292188253 hasAuthorship W4292188253A5069772977 @default.
• W4292188253 hasAuthorship W4292188253A5082465884 @default.
• W4292188253 hasBestOaLocation W42921882531 @default.
• W4292188253 hasConcept C121608353 @default.
• W4292188253 hasConcept C126322002 @default.
• W4292188253 hasConcept C143998085 @default.
• W4292188253 hasConcept C203014093 @default.
• W4292188253 hasConcept C2777701055 @default.
• W4292188253 hasConcept C2780851360 @default.
• W4292188253 hasConcept C38180746 @default.
• W4292188253 hasConcept C71924100 @default.
• W4292188253 hasConcept C72563966 @default.
• W4292188253 hasConcept C8891405 @default.
• W4292188253 hasConceptScore W4292188253C121608353 @default.
• W4292188253 hasConceptScore W4292188253C126322002 @default.
• W4292188253 hasConceptScore W4292188253C143998085 @default.
• W4292188253 hasConceptScore W4292188253C203014093 @default.
• W4292188253 hasConceptScore W4292188253C2777701055 @default.
• W4292188253 hasConceptScore W4292188253C2780851360 @default.
• W4292188253 hasConceptScore W4292188253C38180746 @default.
• W4292188253 hasConceptScore W4292188253C71924100 @default.
• W4292188253 hasConceptScore W4292188253C72563966 @default.
• W4292188253 hasConceptScore W4292188253C8891405 @default.
• W4292188253 hasLocation W42921882531 @default.
• W4292188253 hasLocation W42921882532 @default.
• W4292188253 hasLocation W42921882533 @default.
• W4292188253 hasOpenAccess W4292188253 @default.
• W4292188253 hasPrimaryLocation W42921882531 @default.
• W4292188253 hasRelatedWork W2886039816 @default.

• next