Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292241657> ?p ?o ?g. }
- W4292241657 endingPage "100209" @default.
- W4292241657 startingPage "100209" @default.
- W4292241657 abstract "The Lumpy Skin Disease Virus (LSDV) Neethling vaccine strains have been used for decades for prophylactic immunization of domestic ruminants against the disease. Commercial products against Lumpy skin disease are supplied as live attenuated vaccines and often are associated with adverse reactions warranting studies towards development of safe and efficacious vaccine alternatives. The present study was designed to investigate the ability of Montanide™ Gel 01 PR adjuvanted inactivated Neethling vaccine strain of the lumpy skin disease to induce immune response in rabbits. Complete virus inactivation was achieved following treatment of live vaccine strain with binary ethyleneimine (BEI) at 2 mM final concentration. Inactivated virus antigen, formulated with Montanide™ Gel 01 was injected at 1,00E + 05 and 1,00E + 06 TCID50 per dose in rabbits. The second injection with same vaccine dosages was administered 21 days after the primary vaccination. Rabbits that received a 1,00E + 05 TCID50/dose of inactivated LSDV vaccine formulation induced maximum neutralizing antibody titres on day 13 post second vaccinations. Rabbits vaccinated and prime boosted with the 1,00E + 06 TCID50/dose of inactivated LSDV vaccine formulation, induced neutralizing antibody titres on day 14 after first vaccination. The maximum antibody titres for the 1,00E + 06 TCID50/dose of the inactivated LSDV vaccine formulation was obtained on day 35 post vaccination. The 1,00E + 06 TCID50 dose of the inactivated LSDV vaccine Montanide™ Gel-01 PR formulation induced higher neutralizing antibodies. The MontanideTM Gel-01 PR offers safer profile to oil adjuvants and can be developed further to protect target animals against LSDV in non-endemic areas." @default.
- W4292241657 created "2022-08-19" @default.
- W4292241657 creator A5038392138 @default.
- W4292241657 creator A5049557129 @default.
- W4292241657 creator A5074949208 @default.
- W4292241657 creator A5076017971 @default.
- W4292241657 creator A5091100055 @default.
- W4292241657 creator A5091569181 @default.
- W4292241657 date "2022-12-01" @default.
- W4292241657 modified "2023-10-10" @default.
- W4292241657 title "Improved safety profile of inactivated Neethling strain of the Lumpy Skin Disease Vaccine" @default.
- W4292241657 cites W1106143193 @default.
- W4292241657 cites W1815168934 @default.
- W4292241657 cites W1970310971 @default.
- W4292241657 cites W1983449040 @default.
- W4292241657 cites W1995400848 @default.
- W4292241657 cites W2000644613 @default.
- W4292241657 cites W2047464927 @default.
- W4292241657 cites W2048142833 @default.
- W4292241657 cites W2049615905 @default.
- W4292241657 cites W2091118148 @default.
- W4292241657 cites W2128953086 @default.
- W4292241657 cites W2170303106 @default.
- W4292241657 cites W2380146188 @default.
- W4292241657 cites W2395901308 @default.
- W4292241657 cites W2415500860 @default.
- W4292241657 cites W2766429162 @default.
- W4292241657 cites W2807576877 @default.
- W4292241657 cites W2809749626 @default.
- W4292241657 cites W2895017236 @default.
- W4292241657 cites W2957028724 @default.
- W4292241657 cites W2994406543 @default.
- W4292241657 cites W3009106222 @default.
- W4292241657 cites W3016795914 @default.
- W4292241657 cites W3026903150 @default.
- W4292241657 cites W3115366646 @default.
- W4292241657 cites W4240839723 @default.
- W4292241657 cites W4293281196 @default.
- W4292241657 doi "https://doi.org/10.1016/j.jvacx.2022.100209" @default.
- W4292241657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36051749" @default.
- W4292241657 hasPublicationYear "2022" @default.
- W4292241657 type Work @default.
- W4292241657 citedByCount "4" @default.
- W4292241657 countsByYear W42922416572022 @default.
- W4292241657 countsByYear W42922416572023 @default.
- W4292241657 crossrefType "journal-article" @default.
- W4292241657 hasAuthorship W4292241657A5038392138 @default.
- W4292241657 hasAuthorship W4292241657A5049557129 @default.
- W4292241657 hasAuthorship W4292241657A5074949208 @default.
- W4292241657 hasAuthorship W4292241657A5076017971 @default.
- W4292241657 hasAuthorship W4292241657A5091100055 @default.
- W4292241657 hasAuthorship W4292241657A5091569181 @default.
- W4292241657 hasBestOaLocation W42922416571 @default.
- W4292241657 hasConcept C159047783 @default.
- W4292241657 hasConcept C159654299 @default.
- W4292241657 hasConcept C162156334 @default.
- W4292241657 hasConcept C203014093 @default.
- W4292241657 hasConcept C22070199 @default.
- W4292241657 hasConcept C2522874641 @default.
- W4292241657 hasConcept C2776872762 @default.
- W4292241657 hasConcept C2777863537 @default.
- W4292241657 hasConcept C2779261636 @default.
- W4292241657 hasConcept C2780801004 @default.
- W4292241657 hasConcept C3018913218 @default.
- W4292241657 hasConcept C71924100 @default.
- W4292241657 hasConcept C86803240 @default.
- W4292241657 hasConcept C98274493 @default.
- W4292241657 hasConceptScore W4292241657C159047783 @default.
- W4292241657 hasConceptScore W4292241657C159654299 @default.
- W4292241657 hasConceptScore W4292241657C162156334 @default.
- W4292241657 hasConceptScore W4292241657C203014093 @default.
- W4292241657 hasConceptScore W4292241657C22070199 @default.
- W4292241657 hasConceptScore W4292241657C2522874641 @default.
- W4292241657 hasConceptScore W4292241657C2776872762 @default.
- W4292241657 hasConceptScore W4292241657C2777863537 @default.
- W4292241657 hasConceptScore W4292241657C2779261636 @default.
- W4292241657 hasConceptScore W4292241657C2780801004 @default.
- W4292241657 hasConceptScore W4292241657C3018913218 @default.
- W4292241657 hasConceptScore W4292241657C71924100 @default.
- W4292241657 hasConceptScore W4292241657C86803240 @default.
- W4292241657 hasConceptScore W4292241657C98274493 @default.
- W4292241657 hasFunder F4320320671 @default.
- W4292241657 hasLocation W42922416571 @default.
- W4292241657 hasLocation W42922416572 @default.
- W4292241657 hasLocation W42922416573 @default.
- W4292241657 hasLocation W42922416574 @default.
- W4292241657 hasOpenAccess W4292241657 @default.
- W4292241657 hasPrimaryLocation W42922416571 @default.
- W4292241657 hasRelatedWork W1586998362 @default.
- W4292241657 hasRelatedWork W2008520326 @default.
- W4292241657 hasRelatedWork W2033808970 @default.
- W4292241657 hasRelatedWork W2055156886 @default.
- W4292241657 hasRelatedWork W2061622569 @default.
- W4292241657 hasRelatedWork W2139983200 @default.
- W4292241657 hasRelatedWork W2160128556 @default.
- W4292241657 hasRelatedWork W2412411162 @default.
- W4292241657 hasRelatedWork W4289529812 @default.
- W4292241657 hasRelatedWork W1510441201 @default.