Matches in SemOpenAlex for { <https://semopenalex.org/work/W4292247257> ?p ?o ?g. }
- W4292247257 endingPage "9316" @default.
- W4292247257 startingPage "9316" @default.
- W4292247257 abstract "Wilson’s disease (WD) is a hereditary disorder of copper metabolism, producing abnormally high levels of non-ceruloplasmin-bound copper, the determinant of the pathogenic process causing brain and hepatic damage and dysfunction. Although the disease is invariably fatal without medication, it is treatable and many of its adverse effects are reversible. Diagnosis is difficult due to the large range and severity of symptoms. A high index of suspicion is required as patients may have only a few of the many possible biomarkers. The genetic prevalence of ATP7B variants indicates higher rates in the population than are currently diagnosed. Treatments have evolved from chelators that reduce stored copper to zinc, which reduces the toxic levels of circulating non-ceruloplasmin-bound copper. Zinc induces intestinal metallothionein, which blocks copper absorption and increases excretion in the stools, resulting in an improvement in symptoms. Two meta-analyses and several large retrospective studies indicate that zinc is equally effective as chelators for the treatment of WD, with the advantages of a very low level of toxicity and only the minor side effect of gastric disturbance. Zinc is recommended as a first-line treatment for neurological presentations and is gaining acceptance for hepatic presentations. It is universally recommended for lifelong maintenance therapy and for presymptomatic WD." @default.
- W4292247257 created "2022-08-19" @default.
- W4292247257 creator A5006676599 @default.
- W4292247257 creator A5017095981 @default.
- W4292247257 creator A5031328280 @default.
- W4292247257 creator A5044413253 @default.
- W4292247257 creator A5058319971 @default.
- W4292247257 creator A5073289723 @default.
- W4292247257 date "2022-08-18" @default.
- W4292247257 modified "2023-10-17" @default.
- W4292247257 title "The Role of Zinc in the Treatment of Wilson’s Disease" @default.
- W4292247257 cites W1016679971 @default.
- W4292247257 cites W120834673 @default.
- W4292247257 cites W1525689595 @default.
- W4292247257 cites W1598775474 @default.
- W4292247257 cites W159935040 @default.
- W4292247257 cites W1911278408 @default.
- W4292247257 cites W1956187157 @default.
- W4292247257 cites W1969895675 @default.
- W4292247257 cites W1970379565 @default.
- W4292247257 cites W1975721815 @default.
- W4292247257 cites W1976725601 @default.
- W4292247257 cites W1979500357 @default.
- W4292247257 cites W1981899748 @default.
- W4292247257 cites W1986914546 @default.
- W4292247257 cites W1987557001 @default.
- W4292247257 cites W1992886088 @default.
- W4292247257 cites W1993337379 @default.
- W4292247257 cites W1994634971 @default.
- W4292247257 cites W2000597587 @default.
- W4292247257 cites W2000818170 @default.
- W4292247257 cites W2002628729 @default.
- W4292247257 cites W2002803484 @default.
- W4292247257 cites W2005582889 @default.
- W4292247257 cites W2006510543 @default.
- W4292247257 cites W2007133504 @default.
- W4292247257 cites W2007879300 @default.
- W4292247257 cites W2009009952 @default.
- W4292247257 cites W2011865970 @default.
- W4292247257 cites W2013019566 @default.
- W4292247257 cites W2013919317 @default.
- W4292247257 cites W2014816514 @default.
- W4292247257 cites W2016033388 @default.
- W4292247257 cites W2019658700 @default.
- W4292247257 cites W2023411819 @default.
- W4292247257 cites W2025615265 @default.
- W4292247257 cites W2026126173 @default.
- W4292247257 cites W2033105955 @default.
- W4292247257 cites W2041890833 @default.
- W4292247257 cites W2044627978 @default.
- W4292247257 cites W2047586503 @default.
- W4292247257 cites W2056351448 @default.
- W4292247257 cites W2060422229 @default.
- W4292247257 cites W2061493726 @default.
- W4292247257 cites W2066892621 @default.
- W4292247257 cites W2068066654 @default.
- W4292247257 cites W2073202193 @default.
- W4292247257 cites W2073974637 @default.
- W4292247257 cites W2074605066 @default.
- W4292247257 cites W2077167146 @default.
- W4292247257 cites W2078973467 @default.
- W4292247257 cites W2079522949 @default.
- W4292247257 cites W2080058827 @default.
- W4292247257 cites W2080545065 @default.
- W4292247257 cites W2085863137 @default.
- W4292247257 cites W2090882839 @default.
- W4292247257 cites W2091290489 @default.
- W4292247257 cites W2093724119 @default.
- W4292247257 cites W2097939264 @default.
- W4292247257 cites W2103195615 @default.
- W4292247257 cites W2105406565 @default.
- W4292247257 cites W2110697645 @default.
- W4292247257 cites W2111623550 @default.
- W4292247257 cites W2111658457 @default.
- W4292247257 cites W2114388415 @default.
- W4292247257 cites W2115660554 @default.
- W4292247257 cites W2118500754 @default.
- W4292247257 cites W2118665584 @default.
- W4292247257 cites W2118775158 @default.
- W4292247257 cites W2125848406 @default.
- W4292247257 cites W2126157610 @default.
- W4292247257 cites W2127376721 @default.
- W4292247257 cites W2131979532 @default.
- W4292247257 cites W2134757382 @default.
- W4292247257 cites W2141060691 @default.
- W4292247257 cites W2152364847 @default.
- W4292247257 cites W2154583841 @default.
- W4292247257 cites W2159672615 @default.
- W4292247257 cites W2160786229 @default.
- W4292247257 cites W2161843023 @default.
- W4292247257 cites W2248606527 @default.
- W4292247257 cites W2276295863 @default.
- W4292247257 cites W2312434633 @default.
- W4292247257 cites W2323967128 @default.
- W4292247257 cites W2402730810 @default.
- W4292247257 cites W2411192573 @default.
- W4292247257 cites W2412946701 @default.
- W4292247257 cites W2415454775 @default.